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Öğe Akut myokard infarktüsünde reperfüzyon kriteri olarak fibrin yıkım ürünleri(1998) Cander, Başer; Aksoy, FarukIn this clinical study, patients get a diagnosis of Acute Myocardial Infarction and received thrombolytic therapy by the Deparment of Emergency Medicine, were prospectively examined whether an increase in fibrin degradation products (FDP) could be a criterion of reperfussion. In this study, by means of history, physical examination, ECG and/or biochemical values, patients diagnosed as AMI and had an indication for thrombolytic therapy included 8(%14) female and 48(%86) male patients with a age between 24-79 years (mean value 56.7+/- 11.4) Patients diagnosed as AMI were estimated about the indication of thrombolytic therapy.Prior to therapy, blood samples were taken for biochemical and hematological analysis and than 1.500.000 unite streptocinase were given by infusion in 45 minutes.By the time of infusion the patients were monitorised. Patients having a second pathology which rises FDP and in those which developed complication after thrombolytic therapy were exculed. FDP, CPK and CK-MB values were investigated following the thrombolytic therapy at times 90. minute, 6 and 12 hours after the therapy. The increase in FDP at times 90. minute,6 and 12 hours after the therapy were analysed by means of "khi kare" testKhi kare is found as 59 and pO.000; the increase was significantly high. Again in the values of CPK and CK-MB at times 90. minute, 6 and 12 hours after therapy there was a statistically significant increase. To the peak value of this two enzymes we reached between 6-12 hours; and this was a good sign for a succesful reperfusion. 43In the Sperman corelation analysis between the FDP, CPK and CK-MB values, between the 6. hour FDP and CK-MB values there was a positive statistically correlation (p<0.01). In conclusion; in patients with AMI and a succesful thrombolytic therapy, the increase in FDP values may be a criterion for reperfusion, but for a routine use more investigations are needed.