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Öğe Association between syndecan-4 and subclinical atherosclerosis in ankylosing spondylitis(Lippincott Williams & Wilkins, 2024) Sertdemir, Ahmet L.; Sahin, Ahmet T.; Duran, Mustafa; Celik, Mustafa; Tatar, Sefa; Oktay, Irem; Alsancak, YakupBackground: Despite advances in the diagnosis and treatment of ankylosing spondylitis (AS), the risk of cardiovascular complications in AS patients is still higher than in the general population. Macrophages are at the intersection of the basic pathogenetic processes of AS and atherosclerosis. Although syndecan-4 (SDC4) mediates a variety of biological processes, the role of SDC4 in macrophage-mediated atherogenesis in AS patients remains unclear. Herein, we aimed to investigate the role of SDC4 in subclinical atherosclerosis in AS patients.Methods: Subjects were selected from eligible AS patients and control subjects without a prior history of AS who were referred to the rheumatology outpatient clinics. All participants' past medical records and clinical, and demographic characteristics were scanned. In addition, carotid intima-media thickness (CIMT) measurement and disease activity index measurement were applied to all patients.Results: According to our data, serum SDC4 level was significantly higher among AS patients compared with the control group (6.7 [1.5-35.0] ng/mL vs 5.1 [0.1-12.5] ng/mL, P < .001). The calculated CIMT was also significantly higher in AS patients than in the control group (0.6 [0.3-0.9] mm vs 0.4 (0.2-0.7), P < .001]. Additionally, serum C-reactive protein level and SDC4 level were independent predictors of AS and strongly associated with CIMT. Linear regression analysis showed that serum SDC4 level was the best predictor of CIMT (P = .004).Conclusion: Our data indicate that serum SDC4 levels provide comprehensive information about the clinical activity of the disease and subclinical atherosclerosis in AS patients.Öğe Association of sociodemographical features, antiviral treatment, and necroinflammatory activity with depression and anxiety in chronic hepatitis B patients(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2015) Celik, Mustafa; Demir, Nazlim Aktug; Sumer, Sua; Demir, Lutfi SaltukObjective: Psychiatric disorders like depression and anxiety are known to be more prevalent in patients with chronic hepatitis B than healthy individuals. This increased prevalence may be due to multiple factors such as psychological distress associated with having a chronic disease, necroinflammatory activity in liver, side effects of treatment with antiviral agents or interferons, and/or direct effect of hepatitis viruses on central nervous system. Purpose of this study was to evaluate several risk factors that may be associated with anxiety and depression in patients with chronic hepatitis B. Methods: This study included 195 chronic hepatitis B patients. A psychiatrist made clinical interviews with the patients and filled Sociodemographic Data Form, Hamilton Anxiety Rating Scale (HARS), and Hamilton Depression Rating Scale (HDRS). Needle biopsies were performed to 175 patients who met biopsy criteria of American Association for the Study of Liver Diseases. Knodell Histological Activity Index was used to evaluate biopsy materials. HBV DNA and ALT levels were measured from patients' sera. Findings: In the study sample, 119 patients were males and 76 were females. Mean HARS score was 7.3 +/- 6.2 and mean HDRS score was 8.8 +/- 6.6. Both HARS and HDRS scores were higher in females than males. HARS score was higher in patients with a family history of chronic hepatitis and both HARS and HDRS scores were higher in patients with comorbid medical illness. Alanine aminotransferase, HBV DNA levels, and level of fibrosis in liver biopsy didn't affect HARS or HDRS scores. Also, there wasn't a difference in HARS or HDRS scores according to patients' usage of pegylated interferon, or oral antiviral therapy. Conclusion: Multiple factors affect the relation between chronic hepatitis and psychiatric disorders like anxiety and depression. Results of our study suggest that female sex, presence of a family history for chronic hepatitis B, comorbidity of other medical diseases, and ethnic origin affect more than the level of necroinflammatory activity and cellular damage in the liver or antiviral treatments.Öğe DETERMINATION OF THE RELATIONSHIP BETWEEN CIGARETTE AND SMOKELESS TOBACCO (MARAS POWDER) USE AND DEPRESSION/ANXIETY(Carbone Editore, 2015) Keten, Hamit Sirri; Ersoy, Ozgur; Satan, Yilmaz; Olmez, Soner; Ucer, Huseyin; Sahin, Merve; Celik, MustafaIntroduction: Tobacco consumption is still a serious cause of mortality and morbidity worldwide. Besides cigarette, use of smokeless tobacco is also high. This study aims to evaluate the symptoms of depression and anxiety among people using cigarette or local smokeless tobacco, Maras powder, and those not consuming tobacco products. Materials and methods: This study was conducted in 20 coffee houses in Kahramanmaras city on 353 voluntary males aged between 18 and 64 years. One hundred and thirty one people consuming Maras powder, 98 people consuming cigarette and 124 controls with no history of tobacco product usage were enrolled in the study. The sociodemographic characteristics, the attitudes of Maras powder and cigarette usage, and the scores of Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were recorded. Results: The mean BAI scores were 9.64+/-7.7, 10.45+/-9.04, and 6.87+/-6.51 for Maras powder group, cigarette group and the control group respectively. The mean BAI scores were significantly higher in Maras powder and cigarette groups compared to control group (p=0.002). It was determined that the mean scores of BAI were similar between Maras powder and cigarette groups (p=0.712). The mean BDI scores were 7.41+/-6.96, 7.51+/-8.16, and 5.30+/-5.24 for Maras powder group, cigarette group and the control group respectively. The mean BDI scores were significantly higher in Maras powder (p=0.037) and cigarette groups (p=0.045) compared to control group. It was determined that the mean scores of BDI were similar between Maras powder and cigarette groups (p=0.994). Conclusion: Obtained findings showed that depression and anxiety scores of people consuming Maras powder and cigarette were significantly higher compared to those does not use tobacco products.Öğe Evaluation of Acute Stress Disorder following Pregnancy Losses(Cukurova Univ, Fac Medicine, 2015) Keten, Hamit Sirri; Gencoglan, Salih; Dalgaci, Ahmet Ferit; Avci, Fazil; Satan, Yilmaz; Olmez, Soner; Celik, MustafaPurpose: The aim of this study was to evaluate acute stress disorder in women experiencing a pregnancy loss. Material and Methods: The study included 170 pregnant women presenting to the Obstetrics and Gynecology Clinic in research and training hospital of Kahramanmaras Sutcu Imam University between February 2013 and July 2013. Fifty-four women experiencing a pregnancy loss before the 21st week of gestation (31%) were assigned into the pregnancy loss group and 116 women whose pregnancy continued without any problems (69%) were assigned into the control group. Data were collected with Posttraumatic Stress disorder Scale (PTSDS) and a questionnaire composed of questions about socio-demographic features and history of pregnancy and diseases.. Results: The mean ages of the pregnancy loss group the control group were 28.83 +/- 7.30 years and 28.87 +/- 5.87 years respectively without a significant difference (p=0.968). The mean score for PTSDS was 32.40 +/- 10.24 (min: 17 and max: 52) in all the participants, 35.83 +/- 11.51 in the pregnancy loss group and 30.81 +/- 9.21 in the control group. The women experiencing a pregnancy loss had significantly higher scores for PTSDS. Conclusion: The study revealed that symptoms of posttraumatic stress disorder increased after pregnancy losses. It is of great importance to provide social and psychological support for the couples experiencing a pregnancy loss in terms of their wellbeing. Inability to implement support mechanisms effectively in cases of increased acute stress such as pregnancy loss can predispose to progression to posttraumatic stress disorder.Öğe Study of phylogenetic relationship of Turkish species of Matthiola (Brassicaceae) based on ISSR amplification(Tubitak Scientific & Technological Research Council Turkey, 2016) Dogan, Bekir; Celik, Mustafa; Unal, Murat; Sefali, Abdurrahman; Martin, Esra; Kaya, AylaMatthiola W.T. Aiton is a taxonomically complex genus in which there are many problems, mostly with Matthiola longipetala and M. odoratissima. Matthiola species native to Turkey were collected from various locations in Anatolia, and their DNA was isolated. Revision studies performed on the basis of molecular data obtained from studies conducted in recent years have made the phylogenetic relationships and systematic positions of the taxa more apparent and reliable. Consequently, the remaining taxonomic problems among the species have been resolved through the use of DNA-based molecular analysis methods, which, unlike phenotype studies, are not affected by environmental factors. The inter-simple sequence repeat (ISSR) fingerprinting method was used in the study because its properties were considered to be more reliable and consistent than those of the randomly amplified polymorphic DNA method. DNA fragments were amplified through the use of ISSR primers. The phylogenetic relationships among the taxa were represented on a dendrogram constructed through means of NTSYSpc 2.02 software. The infrageneric and intergeneric phylogenetic relationships between Matthiola and other related genera were also characterized. It was determined that the taxa Matthiola odoratissima and M. ovatifolia are separate but closely related. Moreover, it was observed that the Matthiola longipetala complex forms a separate group within the genera. Clearly, the genera Matthiola, Sterigmostemum, Strigosella, Malcolmia, and Chorispora are phylogenetically differentiated on the dendrogram.
