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    Investigating the effect of gold nanoparticles on hydatid cyst protoscolices under low-power green laser irradiation
    (Turkish Surgical Assoc, 2019) Colak, Bayram; Aksoy, Faruk; Yavuz, Selman; Demircili, Mehmet Emin
    Objective: Various scolicidal agents are applied for the destruction of protoscolices in cysts media. Undesirable complications of the scolicidal agents limit the techniques to treat the cyst disease. Therefore, new non-toxic scolicidal agents are needed. Upon laser light irradiation, the photothermal gold nanoparticles (AuNPs) convert the absorbed laser light into heat through photothermal effect which kills the surrounding protoscolices by rising the temperature of the cysts media. In this study, we introduced biocompatible AuNPs as a non-toxic scolicidal agent to cure liver hydatid cysts. Material and Methods: The protoscoleces were collected from the livers of naturally infected sheeps. In each experimental group, 1.5 mL suspensions of hydatid liquid containing protoscolices were added to test tubes. The test tubes were divided into five groups. Control, AuNPs only, Green laser only, High-dose AuNPs + laser and Low-dose AuNPs + laser groups. Two concentrations (0.4 and 0.8 mL) of AuNPs and three laser powers (30, 50, 150 mW) were applied for 30, 60 and 120 minutes to the groups. Then the ciysts liquid assessed under a light microscope and determined the viability of protoscoleces. Results: Protoscolices in high-dose AuNPs group were destructed up to 89.30% deaths under 150 mW laser power for 120 minutes. However, negligible cell deaths were observed in cases where only AuNPs added or only laser irradiated groups. Increasing the dose of AuNPs or laser power or duration of aplication increased the protoscolosidal death rate. Conclusion: In the study, we have successfully demonstrated that the AuNPs are an effective therapeutic and scolicidal agent to cure hydatid cyst disease under laser irradiation.
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    Kidney transplant with multiple arteries: Our early results
    (Aves, 2012) Erikoglu, Mehmet; Colak, Bayram; Tekin, Ahmet; Kucukkartallar, Tevfik; Tavli, Sakir
    Purpose: The most common anomaly seen in kidneys used for transplantation is numerical anomalies of the renal artery. The aim of our study is to discuss the artery anomalies we detected in renal transplantation cases in our clinic in line with the relevant literature. Materials and Methods: Five (39%) of the patients were female, 8 were male (61%) and their mean age was 43.7 (22-73), mean follow-up period was 30.5 months (4 to 90). For 7 of the patients, the organs were transplanted from a cadaver and 6 were transplanted from living donors. 12 patients had double, 1 patient had three renal arteries. Six patients were given ex vivo pant type side by side reconstruction to obtain a single large artery and the external iliac was anastomosed to the artery. In 1 patient with a small inferior polar artery, the inferior polar artery was ligated. In 1 patient, the arteries were positioned by in situ anastomosis one by one. In one patient with three arteries, the upper arteries were positioned by pant type anastomosis and anastomosed as a single artery, and the lower polar artery was anastomosed with the inferior epigastric artery end to end. Results: In four patients (30.7%) there was delayed graft function, 1 patient (7.6%) developed acute rejection verified with biopsy. In the post-operative period, it was determined that 3 patients had lymphocele which did not require intervention, 1 patient had subcutaneous infection and 1 patient had perirenal hematoma. Subcutaneous infection recovered with antibiotic treatment. As for the patient with perirenal hematoma, the perirenal hematoma resorbed spontaneously. Conclusion: Using kidneys with multiple renal arteries for transplantation brings with it some theoretical risks. Tubular necrosis, delayed graft function and rejection can be seen more frequently due to elongated cold or hot ischemia time. We are of the opinion that large and single renal artery anastomosis obtained with ex vivo pant anastomosis application can decrease the vascular complication risk in multiple renal artery.
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    The relation between follicular adenoma and papillary thyroid carcinoma
    (Aves, 2011) Erikoglu, Mehmet; Colak, Bayram; Aksoy, Faruk; Cakir, Murat; Ozer, Sukru
    Purpose: Follicular adenomas are the most common neoplasms of the thyroid. They are encapsulated and generally solitary lesions. The aim of this study was to assess those patients diagnosed as having follicular adenomas as a result of histopathological examinations during thyroid surgery in our clinic over the last five years and to study the relationship between papillary thyroid carcinoma and follicular adenoma. Patients and Method: Of the 1081 thyroid operations in the last 5 years, 144 patients who were diagnosed with follicular adenoma as a result of histopathological examination after surgery were assessed. Results: 104 of the patients (72.2%) were female and 40 (27.7%) were male. When the pathological reports of the patients diagnosed with follicular adenoma were considered, 29 patients (20,1%) also had papillary carcinoma. (p:0.058). Conclusion: In our study, we commonly detected accompanying follicular adenoma with papillary carcinoma. Because of this, in patients with a diagnosis of follicular neoplasm we consider that surgical treatment should be a total thyroidectomy if there are nodules determined in the same or opposite thyroid lobe.
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    Renal Transplant Results of the Organ Transplant Center of Meram Medical School Between 2003-2011
    (Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2013) Turkmen, Kultigin; Fatih, M. Ehmet Erdu R.; Erikoglu, Mehmet; Gaipov, Abduzhappar; Colak, Bayram; Tekin, Ahmet; Yeksan, Mehdi
    BJECTIVE: Renal transplantation (RTx) is the best therapeutic modality for end-stage renal disease patients. We report 8 years single-centre experience on cadaveric and living donor RTx in terms of demographic features along with graft functions, posttransplant medical complications, patients-graft survivals. MATERIAL and METHODS: We enrolled 66 RTx (female/male: 36/30) patients including 40 cadaveric and 26 living donors. At admission age, gender, causes of renal failure, dialysis typeduration, type of RTx, induction and maintenance immunosuppressive modalities, rejection episodes, biochemistry-hemogram parameters at 1, 6, 12, 24 and 60 months after transplantation and medical complications were obtained from the medical records. RESULTS: Mean recipient age was 41 +/- 11.6 years. Mean transplant duration was 32.2 +/- 31.4 months, and the mean creatinine values was 1.4 +/- 0.9 mg/dl. The most commonly used immunosuppressive protocol was corticosteroid+tacrolimus+mycophenolate mofetil. Delayed graft function, chronic allograft nephropathy and acute rejection were observed in 27.3%, 25.7% and 13.6% of patients, respectively. 1-and 5-year patient survival rates were 100% and 100% for living donor patients and 85% and 85% for cadaveric patients, respectively. 1- and 5-year graft survival rates were 100% and 100% for living donor RTx patients, and 80% and 80% for cadaveric RTx patients, respectively. The most common medical complications were new onset diabetes mellitus and dyslipidemia. The most common early and late infection was urinary tract infection. CONCLUSION: RTx is the best renal replacement therapy in terms of patient-graft survival. However, patients should be closely moniterized for metabolic complications.
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    Retrospective Evaluation of Completion Thyroidectomy Cases
    (Aves, 2013) Colak, Bayram; Kucukkartallar, Tevfik; Aksoy, Faruk; Cakir, Murat; Kartal, Adil; Erikoglu, Mehmet
    Objective: The aim of this study is to investigate the reasons and complications of completion thyroidectomy. Material and Methods: One hundred and ten patients undergone completion thyroidectomy were evaluated according to their age, gender, expenditure, operative technics, recurrence, fine-needle aspiration biopsies cytology, final pathology and complications. Results: Out of 110 patients 97 were female and 13 were male. Fifty six patients were operated on for malign reasons while 54 patients were operated on for benign reasons. 55% of the patients had been sent to our institution from another institution. Multinodular goiter was the most frequent histopathological result followed by papillary thyroid carcinom. Hypocalcemia was detected in 40 patients, seroma in 17 patients, permanent hoarseness resulting from recurrent laryngial nerve injury in 1 patient, esophageal injury in 1 patient, internal jugular vein injury in 1 patient and abscess in 1 patient. Recurrence was detected in the other lobe among from the operated one was in 38% of the patients. Parathyroid tissue was found in the rethyroidectomy piece in 23.6% of the cases. Conclusion: In the second thyroidectomy complications were more severe than the initial thyroidectomy and the rate of incidental parathyroidectomy increases obviously. We believe that the need for completion thyroidectomy and resulting complications can be reduced to a minimum through total thyroidectomy.