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    Aortic stiffness in patients with wilson's disease
    (Wolters Kluwer Medknow Publications, 2019) Gurbuz, A. S.; Ozturk, S.; Efe, S. C.; Demir, K.
    Aim: Wilson's disease (WD) presents with different phenotypes. Neurologic and liver involvement in WD are well documented. Few reports demonstrated cardiac and vascular involvement. Several studies showed an association between serum copper levels and atherosclerosis. Although WD is the prototype disease of copper metabolism, atherosclerosis has not been studied yet. The aim of this study is to assess aortic stiffness in WD. Materials and Methods: Aortic pulse wave velocity (PWV), augmentation pressure (AP), augmentation index (AIx), central aortic systolic, diastolic, mean, and pulse pressures were measured using SphygmoCor (AtCor Medical) device in 32 patients with WD and 24 healthy controls. Results: Patients with WD and healthy controls were similar in terms of age sex, body mass index (BMI), and liver and kiney functions. However, patients with WD were anemic and thrombocytopenic. Echocardiographic parameters including left ventricular, atrial dimensions, and systolic and diastolic functions were similar between two groups. Patients with WD and healthy controls were compared. Baseline characteristics including age, sex, and BMI did not differ between groups. Central aortic systolic, diastolic, mean, and pulse pressures were similar between the groups. AP, AIx, and PWV did not differ between groups as well. Conclusion: Aortic stiffness in WD was similar in healthy controls.
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    Invasive fungal diseases in patients with acute leukemia or allogeneic stem cell transplantion recepients: A prospective multicenter observational study
    (Oxford Univ Press, 2018) Metan, G.; Etgul, S.; Cifticioglu, A.; Saba, R.; Kilic, A. Ulu; Yilmaz, H.; Demir, K.
    [Abstract Not Availabe]
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    Posaconazole prophylaxis in patients with acute myeloid leukemia: A real life experience from a prospective multicenter observational study
    (Oxford Univ Press, 2018) Metan, G.; Etgul, S.; Cifticioglu, A.; Saba, R.; Kilic, A. Ulu; Yilmaz, H.; Demir, K.
    [Abstract Not Availabe]
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    Radiation dose and diagnostic accuracy of high-pitch dual-source coronary angiography in the evaluation of coronary artery stenoses
    (Elsevier Masson, Corporation Office, 2016) Koplay, M.; Erdogan, H.; Avci, A.; Sivri, M.; Demir, K.; Guler, I.; Demir, L. S.
    Purpose: Flash Spiral'' imaging is a new prospective ECG-triggered spiral scan mode that uses a very high-pitch for coronary computed tomography angiography (CTA). This enables complete image acquisition within one cardiac cycle with a very low radiation exposure. The aim of this study was to investigate the diagnostic accuracy, image quality, and effective radiation dose of prospectively ECG-triggered high-pitch spiral method (Flash spiral mode) of coronary CTA using dual-source technology for the evaluation of coronary artery stenoses. Material and methods: The study included 186 consecutive patients (115 men, 71 women; mean age: 53.37 years) who underwent coronary CTA. Coronary CTA was performed with a 128 x 2-slice dual-source CT (Somatom Definition Flash, Siemens, Germany) using a prospectively ECG-triggered high-pitch spiral mode. Patients were divided into three groups according to heart rate (<= 65 bpm, 66-75 bpm, >= 76 bpm) and body mass index (BMI) (20-24 kg/m(2), 25-29 kg/m(2), 30-34 kg/m(2)) values. The correlation between heart rates, image quality and BMI values are investigated. A four-point scale (1 = excellent, 4 = poor/non-diagnostic) was used to rank the comparative image quality. Effective radiation doses were calculated. Also the correlation between radiation dose, sex and BMI values were investigated. In addition, diagnostic accuracy of CTA for detection of significant (= 50%) coronary artery stenoses was compared with invasive coronary angiography findings of 612 vessel segments in 38 patients. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy rate were calculated. Results: A total of 2976 coronary artery segments were present. Of all coronary artery segments, 2381 (80%) had an image quality score of 1, and 1.5% segments were rated as poor/nondiagnostic. When the correlation between heart rate and image quality is investigated, there was a significant difference between < 65 bpm and > 76 bpm groups. However, there was no significant difference between < 65 bpm and 66-75 bpm groups. The mean effective dose was found as 1.3 mSv (min: 0.5, max: 2.4 mSv). The correlation between effective radiation dose and BMI was moderate. However, the correlation between gender and radiation dose was significant. Sensitivity, specificity, negative predictive value and accuracy of coronary CTA on a per -vessel segment were 90.1%, 97.4%, 98.6%, and 96.5%, respectively. Conclusions: Prospectively ECG -triggered high -pitch spiral mode coronary CTA provides high image quality and diagnostic accuracy, with very low radiation dose for evaluation and exclusion of coronary artery stenoses. (C) 2015 Editions franc aises de radiologie. Published by Elsevier Masson SAS. All rights reserved.