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    Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer
    (2018) Deniz, Çiğdem Damla; Gürbilek, Mehmet; Koç, Mehmet
    Objective: Chemoradiotherapy (CRT) is a commonly usedtherapeutic modality. We investigated CRT effects onacute phase reactants (APRs). The aim of this study wasto assess possible changes in APR levels during radiotherapyand to determine the usefulness of APRs as prognosticfactors in patients with non-small cell lung cancer(NSCLC) and glioblastoma multiforme (GBM).Methods: We prospectively evaluated 30 patients and30 healthy controls. Plasma levels of APRs were measured.Post-CRT and pre-CRT levels were compared. Survival ofpatients were also followed up for a period of 3 years.Results: In NSCLC patients, post-CRT albumin, transferrin(Trf), and ceruloplasmin (Cp) levels were significantlylower, and post-CRT ferritin (FER) levels were significantlyhigher, than their pre-CRT levels. In GBM patients, post-CRT Trf and prealbumin (Prealb) levels were significantlyhigher than pre-CRT levels. Pre-CRT C-reactive protein(CRP) and FER levels in NSCLC patients and Cp levels inGBM patients were associated with patient survival.Conclusion: This study suggests that APRs may be usefulfor monitoring response to treatment during CRT in NSCLCand GBM patients. Bearing in mind their accessibility andclinical value, plasma CRP and FER in NSCLC patients andCp in GBM patients can be considered candidate prognosticfactors.
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    Prognostic Value of İnterferon-Gamma, İnterleukin-6, and Tumor Necrosis Factor-Alpha in The Radiation Response of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer and Glioblastoma Multiforme
    (2018) Deniz, Çiğdem Damla; Gürbilek, Mehmet; Mehmet, Koç
    Background/aim: This study aimed to investigate the effect of chemoradiotherapy (CRT) on interferon-gamma, interleukin-6(IL-6), and tumor necrosis factor-alpha, which are critical markers of the clinical radiation response of patients with locallyadvanced non-small-cell lung cancer (NSCLC) and glioblastoma multiforme (GBM).Materials and methods: Thirty patients who were treated with CRT and 20 healthy controls were prospectively evaluated. Circulatinglevels of cytokines were measured by enzyme-linked immunosorbent assay procedure. Post-CRT and pre-CRT levels were compared.Results: Post-CRT, TNF- and IFN- levels were significantly lower than pre-CRT levels in the NSCLC and GBM groups, respectively.The statistical analysis did not show any significant difference between the post- and pre-CRT IL-6 levels. However, the pre-CRT IL-6levels in the GBM group and post-CRT IL-6 levels in the NSCLC group were significantly higher than those of the control group.Conclusion: CRT affected TNF- levels in NSCLC and IFN- levels in GBM, with the levels of both decreasing significantly. The IL-6levels of the post-CRT NSCLC group were higher than those of the post-CRT GBM group. Irradiation-induced IL-6 may be responsiblefor tumor regrowth. Therefore, treatment with IL-6 inhibitors could be a potential therapeutic strategy for sensitizing NSCLC toirradiation in the clinic.