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    Liporotein-associated phospholipase-A2 can be a diagnostic marker in the early stage diagnosis of acute mesenteric ischemia
    (Tubitak Scientific & Technological Research Council Turkey, 2016) Acar, Tarik; Kocak, Sedat; Cander, Basar; Ergin, Mehmet; Dikmetas, Cesareddin
    Background/aim: The purpose of this experimental study was to investigate the role of lipoprotein-associated phospholipase-A(2) (Lp-PLA(2)) in the diagnosis of acute mesenteric ischemia (AMI) in the early stage. Materials and methods: Twenty-seven New Zealand rabbits were randomly divided into 3 groups in this study. Blood specimens were obtained from the groups at hours 0, 1, 3, and 6. Using the blood samples drawn from all groups, Lp-PLA(2) and C-reactive protein (CRP) parameters were investigated. Results: There was a significant rise in the levels of both Lp-PLA(2) and CRP starting at hour 1 (P < 0.05) (hour 1; Lp-PLA(2), P = 0.003) in the ischemia group. In the sham group, the levels of Lp-PLA(2) and CRP started to rise at hour 3 (P < 0.05) (hour 3; Lp-PLA(2), P = 0.011). At hour 6 of ischemia, the area under the ROC curve was 100%, and the cut-off value of 63.91 ng/mL revealed a sensitivity of 88% and a specificity of 100% for Lp-PLA(2). Conclusion: These findings showed the role of serum Lp-PLA(2) and CRP levels in the early diagnosis of AMI. Thus, further studies are needed to describe the role of Lp-PLA(2) in the early diagnosis of AMI.
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    Measurement of Optic Nerve Sheath Diameter to Detect Increased Intracranial Pressure in Hypertensive Patients
    (Emergency Medicine Physicians Assoc Turkey, 2020) Dikmetas, Cesareddin; Ergin, Mehmet; Duman, Cigdem Savas; Gulpembe, Mustafa; Acar, Tarik; Yavuz, Kenan; Cander, Basar
    Aim: Our aim was to measure optic nerve sheath diameter (ONSDM) by ultrasonography and to detect whether ONSDM reflected intracranial pressure in hypertensive patients. Materials and Methods: This observational study was performed prospectively in 149 individuals, 77 (51.7%) of whom were female, including 54 hypertensive-symptomatic patients, 45 hypertensive-asymptomatic patients, and 50 healthy volunteers referred to Emergency Medicine Service of Necmettin Erbakan University, Faculty of Medicine. Blood pressure was measured on the right and left upper extremities by the same sphygmomanometer following at least five minutes of rest. ONSDM was recorded. All measurements of hypertensive-symptomatic patients were repeated at 30th minute following antihypertensive therapy. Results: Moderate-to-well statistically significant correlations were determined between initial mean systolic blood pressure and ONSDM (rho=0.629, p=0.001) as well as between initial mean diastolic blood pressure and ONSDM (rho=0.561, p=0.001) in all study groups. Statistically significant differences were determined between the mean pre- and post-treatment systolic and diastolic blood pressures as well as the mean pre- and post-treatment ONSDM values of 40 patients who received antihypertensive therapy (p=0.000, p=0.000, p=0.000, respectively). Conclusion: Ultrasonographic ONSDM reflected increased intracranial pressure in hypertensive patients. The reduction of intracranial pressure was also detected by the same method following antihypertensive treatment. Ultrasonographic ONSDM along with clinical findings and blood pressure measurements may be used for evaluation of response to treatment and deciding on further imaging.