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    Ceratophyllum demersum L. Extract as a Botanical Insecticide for Controlling the Maize Weevil, Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae)
    (Springer, 2017) Dogan, M.; Emsen, B.; Aasim, M.; Yildirim, E.
    Insecticidal activities of methanol and water extracts, obtained from in vitro propagation of Ceratophyllum demersum L. on maize weevil, Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae) were laboratory studied. In vitro whole plant regeneration was obtained from nodal explants of C. demersum cultured on liquid Murashige and Skoog medium (MS) treated with various combinations of 6-Benzylaminopurine (BAP) and 1-Naphthaleneacetic acid (NAA). Different, concentrations (2.5, 5, 10 and 20 mg/ml) of C. demersum extracts were tested. The highest mortality (100%) caused were determined by both extracts at the concentrations of 10 and 20 mg/ml after 96 h of exposure. LC50 of methanol and water extracts after 96 h were 1.720 and 1.015 mg/ml, respectively. It was detected that mortality was correlated with concentration and exposure time. These findings suggest that C. demersum extract could be considered as an effective biocontrol agent and could be used as an alternative to chemical insecticides.
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    Comparison of the diagnostic values in rheumatoid arthritis: Anti-CCP antibodies and other serological tests
    (Allied Acad, 2014) Dogan, M.; Kucuksarac, S.; Tufekci, O.; Feyzioglu, B.; Ozdemir, M.; Baykan, M.; Baysal, B.
    Rheumatoid arthritis (RA) is an inflammatory autoimmune disease. Early diagnosis, early and aggressive treatment are the best means of avoiding joint destruction, organ damage and disability. This prospective study was carried out to determine the relationship between RA and laboratory tests used in the diagnosis of RA. 199 patients (20 males, 179 females; mean age: 50.6 years) that were suspected to be RA were included in the study. Anti-CCP, RF, ESR, and CRP tests were performed for all patients. The patients were divided two groups named RA and non-RA according to American College of Rheumatology criteria. Of the all patients, 96(48.2%) tested as positive for anti-CCP antibodies. Of the RA patients, 93 (68.9%) were positive for anti-CCP antibodies. The positivity of anti-CCP antibodies was 4.7% (3/64) for non-RA. Sensitivity, specificity, PPV, and NPV in diagnosis of RA for anti-CCP respectively were 0.69, 0.95, 0.97, and 0.59, and for high positive anti-CCP respectively were 0.55, 1.00, 1.00, and 0.52, and for RF respectively were 0.59, 0.92, 0.94, and 0.52, and for high positive RF respectively were 0.54, 0.98, 0.99, and 0.54, and for CRP respectively were 0.73, 0.78, 0.87, and 0.57, and for ESR respectively were 0.84, 0.30, 0.72, and 0.46. Sensitivity for the diagnosis of RA could be further increased by a combination of the anti-CCP and RF tests. There was a positive correlation between anti-CCP and RF positivity (Phi=0.59537), anti-CCP and RF high positivity (Phi=0.537364), ESR and CRP (Phi=0.426544). It is concluded that performing anti-CCP test in the diagnosis of RA could be beneficial since it has high specificity and positive predictive value. If this test was performed together with RF, it may be more beneficial.
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    Efficacy and safety of perioperative FLOT (5-FU, LV, oxaliplatin, docetaxel) chemotherapy in gastric and gastroesophageal junction adenocarcinoma: Real-life data from Turkish oncology group
    (Elsevier, 2021) Erol, C.; Basoglu, T.; Sakin, A.; Ozden, E.; Cubuk, D.; Yumuk, P. F.; Dogan, M.
    [Abstract Not Availabe]
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    Insecticidal Activity of In Vitro Propagated Aquatic Plant Ceratophyllum demersum L. against Granary Weevil Sitophilus granarius L. (Coleoptera: Curculionidae)
    (Egyptian Soc Biological Control Pests, 2016) Emsen, B.; Dogan, M.; Aasim, M.; Yildirim, E.
    Insecticidal activities of methanol and water extracts obtained from in vitro propagated of Ceratophyllum demersum L., were tested on adults of the granary weevil Sitophilus granarius L.. In vitro shoot regeneration was achieved from shoot tip explants of C. demersum cultured on liquid Murashige and Skoog (MS) media containing various combinations of 6- Benzylaminopurine (BAP) and 1-Naphthaleneacetic acid (NAA). Mortality percentages of the insects exposed to different concentrations (2.5, 5, 10 and 20 mg/ml) of the extracts at different intervals of 24, 48 and 96 h were determined. Methanol (99%) and water extracts gave (100%) mortality after 96 h. The lowest median lethal concentration (LC50) values of methanol and water extracts after 96 h were: 2.505 and 1.153 mg/ml, respectively. Furthermore, positive correlations at p < 0.01 level between mortality and concentration; mortality and exposure time for both extracts was detected. Based on the present results, it can be concluded that this aquatic plant extracts of C. demersum may have a potential action for control of S. granarius adults and can be suggested against storage pests.