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Öğe Benign cephalic histiocytosis(Medknow Publications & Media Pvt Ltd, 2013) Daye, Munise; Dogan, Seda; Mevlitoglu, Inci; Toy, Hatice[Abstract Not Availabe]Öğe Lipoid proteinosis (Urbach-Wiethe disease): A case report(Turkish Soc Dermatology Venerology, 2014) Daye, Munise; Dogan, Seda; Mevlitoglu, Inci; Esener, Sarenur; Toy, HaticeLipoid proteinosis, which is known as Urbach-Wiethe disease, was first described in 1929 as lipoidosis cutis et mucosae by Urbach and Wiethe. It is a rare autosomal recessive inherited genodermatosis. There are PAS-positive hyaline material deposits in the skin, mucosa and visceral organs. A 23-year-old man, who was suffering from swelling of the lower lip and a fissure on the inner side of the lip, presented to our outpatient clinic. On dermatological examination, there were lower lip edema and infiltration, as well as macroglossia. There were bilateral yellowish papules along his eyelashes. For his ocular findings; it was learned that he had been treated for trichiasis at his childhood. There were multiple atrophic scars on his face, elbows, axilla, knees, and the skin overlying his spinous processes. He had no hoarseness. There was no consanguinity between his mother and father. Physical examination was normal. Three punch biopsies were carried out from his tongue, lips and elbow with the preliminary diagnoses of lipoid proteinosis, Melkersson-Rosenthal syndrome, focal epithelial hyperplasia, amyloidosis, granulomatous cheihtis, atrofoderma, and anetoderma. Deposition of hyaline PAS-positive materials was observed on his histopathological examination. According to the clinical and histopathological findings, the patient was diagnosed as having lipoid proteinosis. Otorhinolaryngologists, ophthalmologists, dermatologists, and neurologists should keep this rare condition in mind in the differential diagnosis.Öğe Retrospective evaluation of childhood alopecia areata cases(Turkish Soc Dermatology Venerology, 2013) Daye, Munise; Dogan, Seda; Balevi, Sukru; Mevlitoglu, InciBackground and Design: Approximately 20% of alopecia areata (AA) cases are children. There is limited information about childhood AA. We aimed to examine demographic features, treatments and prognosis of children with AA followed in our clinic. Materials and Methods: We retrospectively analyzed the records of 110 AA patients 16 years of age or older. Data on age, gender, age at disease onset, duration of the disease, types of AA and onset area, nail involvement, accompanying systemic and dermatological diseases, laboratory tests, treatments and the prognosis, and follow-up period were evaluated. Results: 46.4% of subjects were female and 53.6% were male. The mean age was 10.35 years. The age at disease onset was 8.65 years. Primary onset areas of AA were: scalp in 83.6% of patients, - eyebrows - in 5.4%, - body hair - in 5.4%, - eyelashes - in 2.7%, and eyebrows and eyelashes in 2.7% of patients. Types of the disease were: AA in 73.4% cases, - alopecia totalis -in 19%, - alopecia universalis - in 5.4%, and ophiaisis in 1.8% of subjects. Nail involvement and nevus flammeus were observed in 36.3% and 27% of subjects, respectively. The mean disease duration was 17.02 months. The accompanying dermatoses were: vitiligo in 2.7% of cases and atopic dermatitis in 6.3% of cases. The accompanying systemic diseases were: autoimmune thyroiditis and Down syndrome in in 1.8% and 2.7% of patients, respectively. Thyroid autoantibodies were found to be high in 0.9% of subjects. We have treated 24.5%of patients with topical corticosteroid lotion, - 30.9%- with anthralin, - 0.9%- with 2% minoxidil lotion, - 0.9%- with calcipotriol lotion, - 1.8%- with topical calcineurin inhibitors, and 10% of cases with intralesional corticosteroids. We have treated 15.4% of subjects, who were resistant to topical treatment, with systemic corticosteroids and PUVA therapy. 14.5% of patients received different combinations of topical treatments. Remission was observed in 34.5% of cases. The mean remission duration was 12.2 months. On average, two relapses occurred in 26.3% of subjects. Conclusion: We assume that our results will contribute to epidemiologic data on childhood AA in our country.