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Öğe Adjunctive Lacosamide Treatment For Adult Focal-Onset Epilepsy: Focus On Comorbid Intellectual/Developmental Disorders And Differing Responses(Wiley, 2018) Dogan, E. A.; Dogan, U.; Genc, E.; Erdogan, C.; Genc, B. O.[Abstract Not Availabe]Öğe AORTIC INTRAMURAL HEMATOMA: A VARIANT OF AORTIC DISSECTION OR A DISTINCT ENTITY?(Elsevier Ireland Ltd, 2013) Dogan, U.; Abdulhalikov, T.; Keskin, S.; Ege, E.[Abstract Not Availabe]Öğe Evaluation of echocardiographic indices for the prediction of major adverse events during long-term follow-up in chronic hemodialysis patients with normal left ventricular ejection fraction(Verduci Publisher, 2012) Dogan, U.; Ozdemir, K.; Akilli, H.; Aribas, A.; Turk, S.Background: Cardiovascular disease is the leading cause of mortality in end-stage renal failure. Prognostic role of echocardiography has not been fully elucidated in chronic hemodialysis patients. Aim: To assess the ability of Doppler echocardiographic parameters of left ventricular (LV) diastolic function along with conventional echocardiographic indices to predict long-term adverse major events in chronic hemodialysis patients with normal LV ejection fraction (EF). Patients and Methods: A total of 45 chronic hemodialysis patients (aged 49 15 years) were included to the study. All patients underwent complete standard and tissue Doppler imaging echocardiography before and immediately after hemodialysis session and were followed-up prospectively. Major outcome measure was the combination of all-cause death and hospitalization for any cardiovascular event. Results: During the follow up period (52 +/- 26 months) 23 major events occured (17 all-cause deaths and 6 cardiovascular events requring hospitalization). Post-dialytic values of mean left atrial diameter, mitral E (peak early mitral inflow velocity), E/Vp [ratio of mitral E to flow propagation velocity (Vp)] and E/Ea [ratio of mitral E to peak early diastolic mitral annular velocity (Ea)] (average of 4 segments of mitral annulus) were significantly higher in patients who had major events. In Cox proportional hazard analysis only E/Ea ratio predicted combined endpoint of all-cause mortality and nonfatal cardiovascular events (hazard ratio: 1.20; confidence interval: 1.03-1.39; p=0.018). The optimum cut-off value for E/Ea determined by ROC curve analysis revealed that E/Ea ratio higher than 9.8 predicted future events with sensitivity of 74% and specificity of 86%. Conclusions: E/Ea might be an accurate echocardiographic indice during long-term follow up for the prediction of major adverse events in chronic hemodialysis patients with normal LV EF.Öğe Evaluation of the acute effect of palonosetron on transmural dispersion of myocardial repolarization(Verduci Publisher, 2012) Dogan, U.; Yavas, G.; Tekinalp, M.; Yavas, C.; Ata, O. Y.; Ozdemir, K.Background: 5-hydroxytryptamine receptor type-3 (5-HT3) antagonists are widely used for prophylaxis of chemotherapy-induced nausea and vomiting (CINV) and regarded to have a high safety profile. However, several electrocardiographic changes and cardiac arrhythmias have been reported due to administration of 5-HT3 antagonists. Only prolongation of QT interval has been investigated as an index of potential for life-threatening arrhythmias in adult patients using 5-HT3 antagonists. Recently, increase in transmural dispersion of repolarization (TDR) has been proposed as a more reliable determinant of arrhythmogenic potential. Aim: To assess the effects of palonosetron, a second-generation 5-HT3 antagonist, on the T-wave peak to T-wave end (TpTe) interval which has been proposed as a reliable index of spatial TDR. Patients and Methods: A total of 50 consecutive cancer patients (aged: 57 +/- 12 years) who were scheduled to receive emetogenic chemotherapy were included to the study. Baseline12-lead electrocardiography (ECG) recordings were obtained. Then, all patients received 8 mg intravenous dexamethasone followed by a single dose of 0.25 mg intravenous palonosetron administered over 30 seconds. A second ECG was performed 30 minutes after the administration of palonosetron. Indices of cardiac repolarization and TOR before and after the administration of palonosetron were compared. Results: In comparison with baseline there was no statistically significant change in any of the heart rate-corrected parameters, including QT(c) (lead V-5), QT(maxc), QT(minc), QT(cd), TpTe (V-5), TpTe(max), TpTe(min), TpTe(d) and TpTe/QT (V-5). Conclusions: Palonosetron does not have any significant effect on QT(c) and TpTe intervals. It might be the drug of choice for prophylaxis of CINV in cancer patients receiving chemotherapy with known cardiotoxic potential or who have pre-existing cardiac disease that predispose them to drug-induced arrhythmias.Öğe PLATYPNEA ORTHODEOXIA SYNDROME FOLLOWING PULMONARY VEIN ISOLATION(Elsevier Ireland Ltd, 2013) Dogan, U.; Can, I.; Kayrak, M.; Kabul, H. K.; Gormus, N.; Kose, S.[Abstract Not Availabe]
