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Öğe Alexithymia in primary ciliary dyskinesia(European Respiratory Soc Journals Ltd, 2023) Caglar, Hanife Tugce; Pekcan, Sevgi; Ercan, Fatih; Turkut, Asli; Unal, Gokcen[Abstract Not Availabe]Öğe The epidemiologic trend of respiratory syncytial virus has returned strongly to its origin after the pandemic: Five-year data from a single center(Wiley, 2023) Caglar, Hanife Tugce; Pekcan, Sevgi; Yilmaz, Asli Imran; Unal, Gokcen; Ercan, Fatih; Savas, Suat; Akcan, Ozge MetinObjective: Only a few studies have investigated the frequency and severity of respiratory syncytial virus (RSV) infections after the end of the pandemic regulations. This study aims to investigate the frequency and severity of RSV infections before, during, and after the pandemic in Turkey.Materials and Methods: Patients under 18 years of age and those who tested positive for RSV between April 2018 and March 2023 were retrospectively reviewed. All patients were divided into three groups (pre-COVID-19, COVID-19, and post-COVID-19) according to admission date. Among inpatients, data were compared between the three groups to determine the impact of the pandemic on RSV epidemiology and clinical outcomes.Results: A total of 9567 patients were tested for RSV, of which 1073 (11.2%) were positive and included in the study. Hospitalization occurred in 447 (41.7%) patients. Inpatients were younger than outpatients (p < .000). Among the three inpatient pandemic groups, clinical outcomes were statistically significantly worse in the post-COVID-19 group than in the other two groups. SpO(2) was lower (p < .000), inhaled salbutamol requirement was higher (p < .000), length of stay was longer (p = .031), and ICU admission was higher (p = .023).Conclusion: Although the RSV trend changed within 2 years after the COVID-19 outbreak, it returned to its usual seasonality last year. After the repeal of all COVID-19 measures and the normal life began, the number of RSV-positive patients and RSV-related hospitalizations increased, and the clinical outcomes of RSV worsened. This may be a result of decreased herd immunity due to a change in society's attitude toward epidemic diseases.Öğe Evaluation of Alexitimia Level in Cystic Fibrosis Patients(European Respiratory Soc Journals Ltd, 2023) Ercan, Fatih; Erden, Semih; Bilgitay, Nail; Pekcan, Sevgi; Unal, Gokcen; Yilmaz, Asli Imran; Caglar, Hanife Tugce[Abstract Not Availabe]Öğe Is Asymmetric Dimethylarginine a Useful Biomarker in Children With Carbon Monoxide Poisoning?(Lippincott Williams & Wilkins, 2019) Yazar, Abdullah; Akin, Fatih; Sert, Ahmet; Ture, Esra; Topcu, Cemile; Yorulmaz, Alaaddin; Ercan, FatihObjective Carbon monoxide poisoning (COP) is the leading cause of mortality and morbidity due to poisoning worldwide. Because children are affected more quick and severely from COP, they may require a longer treatment period, even if carboxyhemoglobin (CO-Hb) and/or lactate levels return to normal. Therefore, a new marker that predicts the duration of treatment and the final outcomes of COP is needed. Methods This case control study was conducted on 32 carbon monoxide-poisoned patients younger than 18 years who had been admitted to pediatric emergency department. The control group included age- and sex-matched 30 healthy children. Blood samples were obtained for analysis of arterial blood gases, CO-Hb percent, methemoglobine, lactate, and asymmetric dimethylarginine (ADMA). Results Asymmetric dimethylarginine levels were significantly increased (P < 0.05) in patients with COP on admission and after the treatment when compared with controls (1.36 [0.89-6.94], 1.69 [0.76-7.81], 1.21 [0.73-3.18] nmol/L, respectively). There was no positive correlation between CO-Hb and ADMA levels on admission and at 6 hours (P = 0.903, r = 0.218, P = 0.231, r = 0.022, respectively). Positive correlation was found between lactate and CO-Hb levels on admission (P = 0.018, r = 0.423). Conclusions This study showed that ADMA levels were still high after 6 hours of 100% oxygen therapy in children with COP, even CO-Hb and/or lactate levels return to normal range. On the basis of these results, we consider that ADMA may be a useful biomarker in patient with COP.Öğe Plastic Bronchitis and Human Bocavirus: A Report of Three Cases(Georg Thieme Verlag Kg, 2023) Yilmaz, Asli Imran; Copur, Ahmet; Parlatan, Havva; Caglar, Hanife Tugce; Unal, Gokcen; Ercan, Fatih; Yazar, AbdullahThis study aims to investigate and analyze the clinical features of coexisting human bocavirus (HBoV) positivity and plastic bronchitis (PB). We present three cases with no known history of cardiac surgery who presented with cough, progressive dyspnea, and atelectasis. They tested positive for HBoV in a real-time polymerase chain reaction of both nasal lavage fluids. They were diagnosed with PB as a result of bronchoscopy and pathology. PB is a rare disease characterized by forming thick rigid casts in the tracheobronchial tree, which can progress to respiratory failure. While asthma or atopy-related type 1 PB was observed in one patient, two patients were diagnosed with PB, which was thought to have developed secondary to viral infections of unknown etiology. As far as we know, HBoV-associated PB cases are rare in the literature. Besides the commonly known infectious agents, we identified a relationship with HBoV in all the presented cases.Öğe Successful treatment of postinfectious bronchiolitis obliterans with gamma globulin in a tertiary center: 10 years of experience(Wiley, 2023) Yilmaz, Asli Imran; Gul, Yahya; Kapakli, Hasan; Unal, Gokcen; Caglar, Hanife Tugce; Ercan, Fatih; Reisli, IsmailIntroductionBronchiolitis obliterans is characterized by partial or total occlusion of the bronchioles due to inflammation and fibrosis, and the most common form is postinfectious bronchiolitis obliterans (PIBO). This study aimed to retrospectively present our intravenous immunoglobulin (IVIG) treatment experience in PIBO patients with a clinically severe course despite receiving commonly used treatment protocols. Materials and MethodsThe study included patients aged 0-18 with subtle immunological abnormalities who were followed up in our center for PIBO between 2010 and 2021. Clinical evaluation, body mass index (BMI), computerized tomography (CT) image scoring, and immunological parameters were recorded before and after IVIG treatment. ResultsOf the 11 patients included in the study, 90% were male, the mean age at diagnosis was 27.1 months (range: 5-68 months) and the mean current age was 81.4 months (range: 15-188 months). The number of hospital visits due to infection and the frequency of hospitalizations decreased markedly in the patients who underwent IVIG therapy. Oxygen therapy was discontinued in all patients, and improvements in radiological severity scores were observed. BMI z-scores improved over the baseline values after IVIG therapy. ConclusionCorticosteroids are considered the best first-line treatment to control inflammation in PIBO. In our study group, PIBO patients showed favorable clinical and radiological responses to regular IVIG treatment, possibly due to minor immune deficiency secondary to steroids or as a result of undetected adaptive and innate immune defects involved in the etiology of severe PIBO.Öğe Yenidoğan yoğun bakım ünitemizin 2010-2019 yılları mortalite verileri(Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, 2020) Ercan, Fatih; Altunhan, HüseyinYenidoğan yoğun bakım ünitemize son 10 yılda yatıp hayatını kaybeden bebeklerin genel özelliklerini, ölüm sebeplerini, risk faktörlerini ve konjenital anomalileri taradık. Verilerimizi literatür ışığında, dünyada ve ülkemizdeki merkezlerle kıyasladık. Amacımız merkezimizde yatan bebeklerdeki ölüm oranını azaltmak için alınabilecek önlemlere katkı sunmaktır. Yöntem: Çalışmaya Ocak 2010 - Ocak 2020 tarihleri arasında, ünitemizde yatıp ölen 491 bebek dahil edildi. Doğum salonunda ölen bebekler, 22 hafta ve altındaki bebekler, 400 gram ve altındaki doğum ağırlığına sahip bebekler çalışmaya alınmadı. Bebeklerin özellikleri retrospektif dosya taraması olarak incelendi. Bulgular: Genel olarak mortalite oranımız %5,02 olarak bulundu. Ölen bebeklerin pekçoğu hastanemizde ve sezaryen doğumla dünyaya gelmişti. Doğum ağırlığı ortalaması 1660,52± 1020,46, doğum haftası ortalaması 31,17± 5,76 olarak bulundu. Bebeklerde en sık ölüm sebebi,respiratuar distres sendromu idi. En sık görülen anomaliler, kardiyovasküler sistemle ilgili olanlardı. Annedeki hastalıklarda ise hipertansif durumlar ilk sıradaydı. Sonuç: Yenidoğan mortalitesi, milletlerin gelişim göstergelerindendir. Ünitemizde son yıllarda ölüm oranları belirgin oranda azalmıştır. Prematüriteye bağlı sorunlar ve anomaliler halen önemli bir problemdir.
