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Öğe Acute Dystonia After Low-Dose Sertraline Treatment A Case Presentation and Review of the Literature(Lippincott Williams & Wilkins, 2023) Erden, Semih; Ferahkaya, Hursit[Abstract Not Availabe]Öğe Could COVID-19 be a trigger for manic attack in an adolescent?(Springer-Verlag Italia Srl, 2021) Uzun, Necati; Kilic, Ahmet Osman; Akinci, Mehmet Akif; ozgul-Katircioglu, Dilek; Erden, Semih[Abstract Not Availabe]Öğe Evaluation of Alexitimia Level in Cystic Fibrosis Patients(European Respiratory Soc Journals Ltd, 2023) Ercan, Fatih; Erden, Semih; Bilgitay, Nail; Pekcan, Sevgi; Unal, Gokcen; Yilmaz, Asli Imran; Caglar, Hanife Tugce[Abstract Not Availabe]Öğe Hypothermia Associated With Melatonin Ingestion in a Child With Autism(Lippincott Williams & Wilkins, 2019) Erden, SemihAutism spectrum disorder is a neurodevelopmental disorder characterized by social interaction and communication disorder and restrictive and repetitive behaviors. Sleep disorders are frequently observed in children with autism spectrum disorder. We present a case of hypothermia in an autistic child with a sleep disorder whose body temperature decreased to 34 degrees C after a single dose of melatonin. Hypothermia continued for 2 more days, but her nighttime sleeping problems decreased. This case is important because it demonstrates the possible risk of hypothermia with melatonin use in children with autism with a sleep disorder.Öğe Investigation of Relaxin-3 Serum Levels in terms of Social Interaction, Communication, and Appetite as a Biomarker in Children with Autism(Korean Coll Neuropsychopharmacology, 2022) Erden, Semih; Nalbant, Kevser; Kilinc, IbrahimObjective: To investigate the possible relationship between relaxin-3 and autism spectrum disorder (ASD). Methods: Serum relaxin-3 was measured in 80 children (50 children diagnosed with ASD and 30 controls). Symptom severity in the ASD group was evaluated by the Childhood Autism Rating Scale (CARS). Behavioral and nutritional problems in the groups were evaluated using the Abnormal Behavior Checklist (ABC) and the Children & apos;s Eating Behavior Results: Our findings showed that serum relaxin-3 levels were higher in children with ASD than in the controls. The listening response sub-scale score of the CARS scale was found to decrease as the level of relaxin-3 increased. However, as relaxin-3 levels increased in children with ASD, it was found that the speech problem sub-scale score on the ABC scale and the desire to drink score on the CEBQ scale increased, but the satiety responsiveness and food fussiness scores decreased. Conclusion: This study the first to investigate serum levels of relaxin-3, which has a role in regulating social behavior and nutritional behavior in children with ASD.Öğe Investigation of the Relation between Epithelial Barrier Function and Autism Symptom Severity in Children with Autism Spectrum Disorder(Springernature, 2022) Nalbant, Kevser; Erden, Semih; Yazar, Abdullah; Kilinc, IbrahimAutism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by limitations in mutual communication and social interaction as well as restricted, repetitive patterns of behaviors, interests, or activities. The possible role of biological abnormalities in the etiopathogenesis of this disorder arouses research interest in this area. This is a case-control study evaluating epithelial barrier function by comparing serum concentrations of occludin and zonulin in children with ASD (n = 60) and controls (n = 30). The Childhood Autism Rating Scale (CARS) was used to evaluate autism symptom levels in all children. Serum occludin and zonulin levels were analyzed using an enzyme-linked immunosorbent assay. Serum occludin was significantly lower in children with ASD than in control subjects. In children with ASD, a decrease in occludin level was significantly associated with the disorder symptom levels items mean score (CARS total scores). Our findings showed that children with ASD had alterations in epithelial barrier function compared to the control group. The investigation of the mechanism underlying the different levels of occludin between ASD and controls may be of importance in clarifying the etiopathogenesis of ASD, as well as its follow-up and treatment.Öğe Oculogyric Crisis Due to Low-Dose Olanzapine: A Case Report(Lippincott Williams & Wilkins, 2021) Erden, Semih; Ferahkaya, HursitObjectives: Oculogyric crisis is a dystonic movement disorder characterized by continuous contraction of the ocular muscles and spasmodic movements of the pupils in a fixed position, usually upward. Methods: In this case report, an early-stage acute oculogyric crisis due to low-dose olanzapine in a 15-year-old adolescent boy is presented. Results: To the best of our knowledge, this is the first report showing that acute oculogyric crisis can develop with low-dose olanzapine administration. Conclusions: Even though second-generation antipsychotics are safer than conventional antipsychotics in terms of extrapyramidal adverse effects, this possibility should always be taken into consideration through this case report.Öğe Pediatric bone marrow transplantation: Psychopathologic features in recipients along with siblings(Wiley, 2019) Erden, Semih; Kuskonmaz, Buelent Baris; Cetinkaya, Duygu Uckan; Unal, Fatih; Ozsungur, BernaObjective To analyze the development of psychopathology in recipients along with their donor and nondonor siblings and the relationship with the bone marrow transplantation (BMT) process. Methods All children were interviewed using the Kiddie Schedule for Affective Disorders and Schizophrenia to assess psychopathology. The depression and anxiety symptoms and self-esteem of children and adolescents were evaluated using the Children's Depression Inventory, State-Trait Anxiety Inventory for Children, State-Trait Anxiety Inventory, and Rosenberg Self-Esteem Scale. Results In this study, the depressive symptom level was found significantly higher in the donor group compared with the nondonor group. State anxiety symptoms were higher in the BMT group (P < .05). There were no significant differences in trait anxiety symptoms. Self-respect was higher in children in the donor group compared with those in the BMT group (P < .05). During the transplant process, children with bone marrow transplants had a higher prevalence of depression, anxiety disorder, and attention-deficit/hyperactivity disorder, and nondonor siblings had a higher prevalence of depressive disorder, anxiety disorder, and attention-deficit/hyperactivity disorder compared with society in general. Conclusion Physicians should deal with the family as a whole, not just their patient, and should be aware of the psychiatric risk of other siblings during the assessment.Öğe Serum B12, homocysteine, and anti-parietal cell antibody levels in children with autism(Taylor & Francis Ltd, 2022) Erden, Semih; Akbas Ileri, Betul; Sadic Celikkol, Cagla; Nalbant, Kevser; Kilinc, Ibrahim; Yazar, AbdullahAims To compare vitamin B12, homocysteine, and anti-parietal cell antibody (APCA) levels between children with ASD and controls, paired in terms of age, sex, and socioeconomic level. Methods The research group consisted of 69 children, 36 with ASD and 33 controls. The severity of ASD was determined using the Childhood Autism Rating Scale (CARS). Serum vitamin B12, homocysteine and human anti-parietal cell levels were analysed using enzyme-linked immunosorbent assay. Results The serum vitamin B12 and homocysteine levels in children with ASD were lower than in the control group, but there was no significant difference in terms of APCA levels. Conclusions Deficiencies in micronutrients, such as B12, may play a role in the pathogenesis and clinical symptoms of autism. However, it is believed that these parameters should be analysed in a wider population to clarify their effect on the aetiology of ASD.Öğe Sleep-Related Bruxism Response to Melatonin Treatment(Mary Ann Liebert, Inc, 2020) Erden, Semih[Abstract Not Availabe]Öğe Visual Hallucinations Induced by Clarithromycin in a Child: A Case Report and Literature Review(Lippincott Williams & Wilkins, 2019) Gokturk, Bahar; Erden, SemihObjective Our aim was to present a child with visual hallucinations possibly associated with oral clarithromycin administration. Case report A 4-year-old child was admitted to our hospital with an onset of visual hallucinations after taking the second dose of clarithromycin by mouth. The symptoms gradually disappeared in a week once the clarithromycin therapy had been discontinued. She was observed for a month without any symptoms or further treatment. She was suspected of having Hoigne syndrome (also called as antibiomania) induced by clarithromycin syndrome. Conclusion This report highlights neuropsychological adverse effects due to therapeutic doses of clarithromycin therapy as a possible adverse effect in children.