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Öğe The bisbenzothiazole-p-tert-butylcalix[4]arene-thiourea Langmuir-Blodgett thin films: preparation, optical properties, swelling dynamics and gas sensing properties via host-guest principles(Springer, 2022) Bozkurt, S.; Durmaz, M.; Erdogan, M.; Erdogan, C. Ozkaya; Capan, R.; Acikbas, Y.Calix[4]arene-based materials have been investigated to develop selective, sensitive, and low cost chemical sensors due to their simple, low cost synthesis, and wide range of chemical and physical properties. In this study, bisbenzothiazole-p-tert-butylcalix[4]arene-thiourea (BBTC[4]T) molecules were employed to produce thin films via Langmuir-Blodgett (LB) thin film fabrication technique. The optical properties and gas sensing abilities of these BBTC[4]T LB films were examined by Surface Plasmon Resonance (SPR) method. In order to illuminate the optical properties of calix[4]arene-based LB films the Winspall software was utilized by fitting the experimental data obtained from SPR device. The values of 1.23 +/- 0.07 nm and 1.53 +/- 0.05 were determined for the thickness per monolayer and the refractive index of BBTC[4]T-based LB films, respectively. The fabricated optical sensor was employed for its sensing abilities against to organic vapours (acetone, ethyl alcohol, methyl alcohol and isopropyl alcohol) via the mechanism of host-guest interaction. The current study also describes the diffusion coefficients of these organic vapours to illuminate the swelling dynamics' BBTC[4]T-based LB thin films by performing the early-time Fick's diffusion equation. The responses of calix[4]arene-based optical sensor in terms of the shift in reflective intensity and the values of diffusion coefficients showed that BBTC[4]T molecules can be developed as potential chemical sensor element for acetone vapour compared to alcohol vapours.Öğe Fas/FasL gene polymorphism in patients with Hashimoto's thyroiditis in Turkish population(Springer, 2017) Erdogan, M.; Kulaksizoglu, M.; Ganidagli, S.; Berdeli, A.Objective Hashimoto's disease is a polygenic disorder with complex etiopathogenesis. Apoptosis is proposed as one of its mechanisms. The Fas/Fas ligand cascade represents a major pathway initiating apoptosis. This study aims to evaluate the influence of Fas and FasL gene polymorphism in Hashimoto's thyroiditis in Turkish population. Materials and methods A total of 112 patients with Hashimoto's thyroiditis and 112 cases of healthy control people were included in this study. The evaluation of genotype for Fas -670 A/G and FasL 843 C/T gene polymorphism was performed by using PCR-RFLP method. Results The FAS genotype and gene allele frequency distribution did differ between the control group (AA 36.6 %, AG 50.0 %, GG 13.4 %, A 61.6 %, G 38.4 %) and the Hashimoto's thyroiditis patients (AA 21.4 %, AG 50.9 %, GG 27.7 %, A 46.9 %, G 53.1 %) (p < 0.01). The evaluation of FasL genotype and gene allele frequency did not show statistically significant difference between the patient group (CC 27.7 %, CT 45.5 %, TT 26.8 %, C 50.4 %, T 49.6 %) and control group (CC 33.9 %, CT 44.6 %, TT 21,4 %, C 56.3 %, T 43.8 %) ( p > 0.05). Conclusions Gene polymorphism of Fas and G allele frequency may play a role in the regulation of apoptosis in thyroid autoimmune disorders. There is a need for further studies to clarify the genetic role of apoptosis in HT.Öğe Genetic variations in interleukin 6 rs1800795 polymorphism and the association with susceptibility to Hashimoto's thyroiditis(Elsevier, 2017) Erdogan, M.; Kulaksizoglu, M.; Ganidagli, S.; Berdeli, A.Hashimoto's disease is a polygenic disorder with complex etiopathogenesis. The imbalance between pro- and anti-inflammatory cytokines may play a role in the etiology. We aimed to evaluate the relation between 174 promoter region of the interleukin 6 rs1800795 gene polymorphism in patients with Hashimoto's thyroiditis (HT). We studied 110 HT patients and 110 healthy controls. The evaluation of genotype for interleukin 6 rs1800795 gene polymorphism were performed by using PCR-RFLP method. The genotype of IL6 distribution did differ between the control group (CC 17.3%, GC 78.2%, GG 4.5%) and the HT patients (CC 29.1%, GC 46.4%, GG 24.5%) (p < 0.001). The frequency of the polymorphic G allele was similar for the group with HT patients as the control group with 47.7% and 43.6%, respectively (p > 0.05). Our results indicate that interleukin 6 rs1800795 polymorphism may be associated with susceptibility to HT in Turkish Patients. It is necessary to confirm the results and determine the underlying pathogenic mechanisms in further studies. (C) 2016 Elsevier B.V. All rights reserved.Öğe Optical and organic vapor properties of Calix[4]arene based macrocyclic Langmuir-Blodgett thin films(Natl Inst Optoelectronics, 2021) Acikbas, Y.; Zeybeka, N.; Ozkaya, C.; Sirit, A.; Erdogan, M.; Capan, R.; Bozkurt, S.Surface Plasmon Resonance (SPR) optical chemical sensors based on 25,27-Bis(N-[[(2R)-2-hydroxy-3-[[(1R)-1-(hydroxymethyl)propyl]amino]propyl]asetamide))-26,28-dihydroxy-5,11,17,23-tetra(tert-butyl)calix[4]arene (NHDACx) films were fabricated to sense dichloromethane, acetone, and benzene at room temperature. Calix[4]arene based macrocyclic thin films, as gas sensing film, were fabricated by Langmuir-Blodgett (LB) thin film technique with different thicknesses, and characterized by SPR and UV-Visible spectrophotometer. The experimental SPR data were fitted using the Winspall software to evaluate optical properties of the NHDACx film such as the parameter of thickness and refractive index. Values of the thickness and refractive index of NHDACx LB films were determined as 1.29 +/- 0.06 nm for the thickness per monolayer, and 1.54 +/- 0.07 for the refractive index. Exposed to above mentioned organic vapors, the responses of the optical sensors, Delta I, were measured. Optical sensor with 7.9 nm NHDACx film shows higher response to the saturated concentration of all vapors than the others, due to the amount of the adsorbed vapor molecules onto the surface of NHDACx film. Sensing mechanisms are based on changing photodetector response and optical properties of the gas sensing element. As a result, NHDACx optical LB thin film sensors exhibits high response, a good sensitivity and selectivity for saturated dichloromethane vapor than other vapors. These optical thin film sensors were potential candidates for organic vapor sensing applications with simple and low cost preparation at room temperature.
