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Öğe Comparison of Parkinson?s patients with and without COVID-19 in terms of prognosis(Asean Neurological Assoc, 2023) Eren, Fettah; Dikmen, Yagizhan; Gur, Merve Nur; Ekmekci, Ahmet Hakan; Sumer, Sua; Ozturk, SerefnurBackground & Objectives: This study aimed to compare PD patients with and without COVID-19 and to evaluate the associated factors about prognosis.Methods: The data of 37 hospitalized PD patients associated with COVID-19 pneumonia were evaluated. It was compared with the data of 40 PD patients who did not have COVID-19 in the same period. Clinical findings, prognosis, mortality and other related factors were compared in PD patients with and without COVID-19.Results: Hypertension was higher comorbid disease in PD patients with COVID-19 (p = 0.005). The duration of PD was longer in patients without COVID-19 disease (6.02 +/- 2.80 vs 5.08 +/- 4.59) (p = 0.028). In PD patients with COVID-19, the most common symptoms were myalgia-arthralgia (73.0%) and fatigue (48.6%). Intensive care was required in 17 (45.9%) patients, and invasive mechanical ventilation (IMV) was required in 9 (24.3%) patients. The in-hospital mortality rate was 29.7% (n = 11). Mortality and IMV requirement were higher in patients whose initial symptom was diarrhea (p = 0.004, p = 0.008, respectively). No correlation was detected between PD stage, treatment options and prognosis (p < 0.05).Conclusion: Mortality rate and IMV requirement are higher in PD patients with COVID-19 pneumonia, particularly in patients with initial symptoms of diarrhea. These patients should be followed more carefully in terms of probable poor prognosis.Öğe The Platelet/Lymphocyte Ratio in Patients with Ischemic Stroke Treated with Intravenous Thrombolysis and Its Relationship with Mortality, Disability, and Prognosis(Galenos Publ House, 2021) Eren, Fettah; Demir, Aysegul; Eren, GulluIntroduction: The platelet/lymphocyte ratio (PLR) has been studied frequently to determine the prognosis of cardiovascular diseases, chronic inflammatory diseases, and malignancies. Particularly, the PLR is an indicator of systemic inflammation and atherosclerosis. In this study, we aimed to evaluate the value of the PLR and its relationship with mortality, cerebral hemorrhagic transformation, and short-term prognosis in patients with stroke treated with intravenous thrombolysis. Methods: Two hundred fifty stroke patients treated with intravenous thrombolysis were included in the study. Initial symptoms, comorbidities, and localization of cerebral ischemia were recorded. Disability was scored on the National Institutes of Health (NIH) stroke scale. At the 24Th and 72nd hours after treatment, hemorrhagic transformation was evaluated by brain computed tomography. The in-hospital mortality rate was calculated. Patients were divided into groups according to the difference in the NIH stroke scale (between admission and discharge). Serum platelet and lymphocyte levels and PLR values were determined. Results: There were 128 (51.2%) female and 122 (48.8%) male patients included in the study. Their mean age was 71.88 +/- 12.36 years. The lymphocyte count was low and the PLR was high in patients with a high level of initial disability (p<0.01). The lymphocyte count was higher in patients with clinical improvement (p=0.023). The lymphocyte count was lower and the PLR was higher in patients who died (p<0.01). The platelet level was lower in patients with hemorrhagic transformation (p=0.024). The lymphocyte level and PLR were similar in the hemorrhagic transformation groups (p=0.156, p=0.675). Conclusion: In this study, it was determined that mortality is related to the PLR, and hemorrhagic transformation is related to platelet levels in patients with ischemic stroke treated with intravenous thrombolysis.