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Öğe BK Virus Nephropathy in Renal Transplantation: Case Series and Review of the Literature(Aves, 2020) Baloglu, Ismail; Turkmen, Kultigin; Esen, Haci Hasan; Selcuk, Nedim Yilmaz; Tonbul, Halil ZekiObjective: BK virus nephropathy (BKVN) is an important cause of kidney transplant failure. In this study, we aimed to evaluate our center's experience with BKVN in patients who had undergone renal transplantation and also discussed important aspects of the disease in this patient population. Materials and Methods: In this study, 8 patients with BKVN were evaluated retrospectively, having been selected from a group of 330 patients (178 females, 152 males; mean age: 48.37 +/- 13.25 years) who had undergone renal transplantation between 2007 and 2017 and were followed up at our center. Results: BKVN was detected in 8 of 330 renal transplantation patients (4 females, 4 males; mean age: 51.25 +/- 11.14 years). Their immunosuppressive regimen consisted of tacrolimus (FK), mycophenolate mofetil (MMF), and methylprednisolone. To reduce immunosuppressive dose, FK was discontinued in 3 patients, and they were switched to everolimus. In 2 of 7 patients, MMF was discontinued, and they were switched to azathioprine. FK or MMF doses were reduced in the8 patients with BKVN. Out of the 8 patients, cidofovir was administered to 1 patient, whereas intravenous immunoglobulins were administered to 3 patients. Additionally, pulse steroid treatment was administered to 1 patient who was diagnosed with acute rejection based on allograft biopsy findings. Among the 8 patients with BKVN, 1 (12.5%) experienced graft loss and was returned to hemodialysis treatment. Conclusion: Although new alternative treatments are available, immunosuppressive dose reduction is still considered the most effective treatment. Therefore, we believe that effective screening and preemptive strategies should be defined more clearly instead of focusing on treatment strategies.Öğe A Case Of Sporadic Mesenteric Fibromatosis Mimicking Pancreatic Mass(Cukurova Univ, Fac Medicine, 2015) Tasci, Halil Ibrahim; Cakir, Murat; Esen, Haci HasanThe term abdominal fibromatosis refers to sporadic, pelvic, and mesenteric lesions and to all the fibromatosis lesions seen in Gardner's syndrome. Sporadic fibromatosis, however, is very rarer and literature offers a limited number of cases. The 14-year-old female patient presented to our clinic with complaints of indefinite abdominal pain in the epigastric area for the last 2 months, dyspeptic problems, and vomiting after eating. Upon the patient's gastroscopy revealed a mass lesion pressuring the stomach, endoscopic ultrasonography was performed. A hyperechoic mass lesion of 9x5 cm thought to have originated from the pancreatic tail was detected. The mass was surgically excised. Although mesenteric fibromatosis shows the characteristics of a benign tumor pathologically, it is extremely aggressive clinically and has a very high rate of recurrence. These patients should be treated like they have malign tumors and surgeons should perform surgical resection as wide as possible.Öğe Chemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in rats(Elsevier Ireland Ltd, 2015) Cuce, Gokhan; Cetinkaya, Seda; Koc, Tugba; Esen, Haci Hasan; Limandal, Cisem; Balci, Tevfik; Kalkan, SerpilCyclophosphamide (CP) has a range of adverse effects on liver tissue in humans and animals. Administering an antioxidant with CP might reduce such side effects. Therefore, we examined the role of vitamin E in CP-induced liver toxicity in rats. Male Wistar albino rats were divided into four groups, each of seven rats: control, CP only, CP + vitamin E, and vitamin E only groups. The rats were administered treatments intraperitoneally for 7 days. Then the serum malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate transaminase (AST), and lactate dehydrogenase (LDH) levels were determined while the livers were removed, tissue was prepared using routine histological procedures, sections were stained using hematoxylin and eosin, and the terminal deoxynucleotidyl transferase-mediated nick end-labeling (TUNEL) method was applied. Histopathologically, CP caused hydropic degeneration, necrosis, pleomorphism, and mitotic activity. The number of TUNEL-positive cells and the MDA and ALT levels were significantly higher in the CP group. The antioxidant effects of vitamin E significantly decreased the number of TUNEL-positive cells and the ALT and MDA levels, and normalized the liver histopathology. CP induces apoptosis, has toxic effects on liver tissue, and changes the histological structure. The administration of vitamin E prevented the liver tissue damage caused by CP. (C) 2015 Elsevier Ireland Ltd. All rights reserved.Öğe Comparison of the effects of alpha lipoic acid and dexpanthenol in an experimental tracheal reconstruction animal model(Saudi Med J, 2023) Kuru, Murat; Altinok, Tamer; Metin, Bayram; Esen, Haci HasanObjectives: To investigate the positive effects of intraperitoneal administration of alpha-lipolic acid (ALA) and dexpanthenol (DXP) on wound healing after tracheal surgery in rats. Methods: The study was carried out at Necmettin Erbakan University, Konya, Turkey, from January 2014-2019. A total of 30 healthy and adult Sprague-Dawley type female rats were included in the study. For the experiment, rats were randomly divided into 3 groups: ALA group (n=10), DXP group (n=10), and control group (n=10). After trachea surgery, 100 mg/kg/day ALA was given to group ALA and 100 mg/kg/day intraperitoneal DXP to group DXP for 15 days, and the rats were sacrificed on the 21st day. The excised tracheal sections were evaluated and graded for inflammatory cell infiltration, angiogenesis, fibroblast proliferation, collagen deposition, and epithelial regeneration to evaluate wound healing. Results: Inflammation was found to be less in both the ALA and DXP groups. With the Mann-Whitney test, it was determined that inflammation was less in the ALA group than in the DXP group (C-D [p=0.097] and C-A [p=0.024]). On the other hand, no statistically significant difference was found in epithelial regeneration (p=0.574; >0.05), angiogenesis (p=0.174; >0.05), fibroblast proliferation, and collagen deposition (p=0.102; >0.05). Conclusion: Alpha-lipolic acid injected intravenously after tracheal reconstruction in patients can prevent restenosis by reducing inflammation without adversely affecting wound healingÖğe Comparison of the effects of alpha lipoic acid and dexpanthenol in an experimental tracheal reconstruction animal model(Saudi Med J, 2023) Kuru, Murat; Altinok, Tamer; Metin, Bayram; Esen, Haci HasanObjectives: To investigate the positive effects of intraperitoneal administration of alpha-lipolic acid (ALA) and dexpanthenol (DXP) on wound healing after tracheal surgery in rats. Methods: The study was carried out at Necmettin Erbakan University, Konya, Turkey, from January 2014-2019. A total of 30 healthy and adult Sprague-Dawley type female rats were included in the study. For the experiment, rats were randomly divided into 3 groups: ALA group (n=10), DXP group (n=10), and control group (n=10). After trachea surgery, 100 mg/kg/day ALA was given to group ALA and 100 mg/kg/day intraperitoneal DXP to group DXP for 15 days, and the rats were sacrificed on the 21st day. The excised tracheal sections were evaluated and graded for inflammatory cell infiltration, angiogenesis, fibroblast proliferation, collagen deposition, and epithelial regeneration to evaluate wound healing. Results: Inflammation was found to be less in both the ALA and DXP groups. With the Mann-Whitney test, it was determined that inflammation was less in the ALA group than in the DXP group (C-D [p=0.097] and C-A [p=0.024]). On the other hand, no statistically significant difference was found in epithelial regeneration (p=0.574; >0.05), angiogenesis (p=0.174; >0.05), fibroblast proliferation, and collagen deposition (p=0.102; >0.05). Conclusion: Alpha-lipolic acid injected intravenously after tracheal reconstruction in patients can prevent restenosis by reducing inflammation without adversely affecting wound healingÖğe The effect of low-intensity pulsed ultrasound on rib fracture: An experimental study(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2020) Calik, Saniye Goknil; Calik, Mustafa; Kasdogan, Zumrut Ela Arslan; Yilmaz, Halim; Karaca, Gulten; Akkurt, Halil Ekrem; Esen, Haci HasanBackground: In this study, we aimed to investigate the effects of low-intensity pulsed ultrasound on rib fracture healing in a rat model. Methods: A total of 72 male Wistar-Albino rats were randomly divided into three equal groups. To induce a rib fracture, right thoracotomy was performed under general anesthesia and a 0.5-cm segment was removed from the fourth and fifth ribs. After 24 h of surgery, low-intensity pulsed ultrasound was implemented according to the groups. Group 1 served as the control group for the observation of normal bone healing. Low-intensity pulsed ultrasound was applied at a dose of 20% (2 msn pulse-8 msn pause) 100 mW/cm(2) and 50% (5 msn pulse-5 msn pause) 200 mW/cm(2) for six min, respectively in Group 2 and Group 3. All subjects were followed for six weeks. Eight animals from each group were sacrificed at two, four, and six weeks for further assessment. Histological alterations in the bone were examined. Results: Although there was no statistically significant difference in osteoblasts, osteoclasts, new bone formation, and lymphocyte count among the groups, histological consolidation was significantly increased by low-intensity pulsed ultrasound. While low-intensity pulsed ultrasound induced osteoblastic, osteoclastic, and new bone formation, it inhibited lymphocyte infiltration. Conclusion: Low-intensity pulsed ultrasound, either at low or high doses, induced the histological consolidation of rib fractures and inhibited lymphocyte infiltration. This effect was more prominent in the long-term and at higher dose with increased daily and total administration time. We, therefore, believe that accelerating the natural healing process in patients with rib fractures would enable to treat more effectively in short-term.Öğe Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in rats(Univ Sao Paulo Fac Odontologia Bauru, 2015) Saglam, Mehmet; Koseoglu, Serhat; Hatipoglu, Mukerrem; Esen, Haci Hasan; Koksal, EkremObjectives: Sumac (Rhus coriaria L.) is widely used spice which has several properties such as antioxidant, anti-inflammatory and antimicrobial. The purpose of this animal study was to evaluate the effects of sumac extract on levels of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG) expression, serum oxidative status, and alveolar bone loss in experimental periodontitis. Material and Methods: Twenty-four Wistar rats were separated into three groups: non-ligated (NL, n=8), ligature only (LO, n=8), and ligature and treated with sumac extract (S, n=8) (20 mg/kg per day for 11 days). A 4/0 silk suture was placed around the mandibular right first molars subgingivally; after 11 days, the rats were sacrificed, and alveolar bone loss was histometrically measured. The detection of RANKL and OPG were immunohistochemically performed. Levels of serum total antioxidant status (TAS)/total oxidant status (TOS), and oxidative stress index (OSI) were also analyzed. Results: Alveolar bone loss was significantly greater in the LO group compared to the S and NL groups (p<0.05). The number of inflammatory cell infiltrate (ICI) and osteoclasts in the LO group was significantly higher than that of the NL and S groups (p<0.05). The number of osteoblasts in the LO and S groups was significantly higher than that of the NL group (p<0.05). There were significantly more RANKL-positive cells in the LO group than in the S and NL groups (p<0.05). OPG-positive cells were higher in S group than in LO and NL groups (p<0.05). TOS and OSI levels were significantly reduced in S group compared to LO group (P<0.05) and TAS levels were similar in S and NL group (p>0.05). Conclusions: The present study showed that systemic administration of sumac extract may reduce alveolar bone loss by affecting RANKL/OPG balance, TOS and OSI levels in periodontal disease in rats.Öğe Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in rats(Univ Sao Paulo Fac Odontologia Bauru, 2015) Saglam, Mehmet; Koseoglu, Serhat; Hatipoglu, Mukerrem; Esen, Haci Hasan; Koksal, EkremObjectives: Sumac (Rhus coriaria L.) is widely used spice which has several properties such as antioxidant, anti-inflammatory and antimicrobial. The purpose of this animal study was to evaluate the effects of sumac extract on levels of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG) expression, serum oxidative status, and alveolar bone loss in experimental periodontitis. Material and Methods: Twenty-four Wistar rats were separated into three groups: non-ligated (NL, n=8), ligature only (LO, n=8), and ligature and treated with sumac extract (S, n=8) (20 mg/kg per day for 11 days). A 4/0 silk suture was placed around the mandibular right first molars subgingivally; after 11 days, the rats were sacrificed, and alveolar bone loss was histometrically measured. The detection of RANKL and OPG were immunohistochemically performed. Levels of serum total antioxidant status (TAS)/total oxidant status (TOS), and oxidative stress index (OSI) were also analyzed. Results: Alveolar bone loss was significantly greater in the LO group compared to the S and NL groups (p<0.05). The number of inflammatory cell infiltrate (ICI) and osteoclasts in the LO group was significantly higher than that of the NL and S groups (p<0.05). The number of osteoblasts in the LO and S groups was significantly higher than that of the NL group (p<0.05). There were significantly more RANKL-positive cells in the LO group than in the S and NL groups (p<0.05). OPG-positive cells were higher in S group than in LO and NL groups (p<0.05). TOS and OSI levels were significantly reduced in S group compared to LO group (P<0.05) and TAS levels were similar in S and NL group (p>0.05). Conclusions: The present study showed that systemic administration of sumac extract may reduce alveolar bone loss by affecting RANKL/OPG balance, TOS and OSI levels in periodontal disease in rats.Öğe The Effectiveness of Crataegus orientalis M Bieber. (Hawthorn) Extract Administration in Preventing Alveolar Bone Loss in Rats with Experimental Periodontitis(Public Library Science, 2015) Hatipoglu, Mukerrem; Saglam, Mehmet; Koseoglu, Serhat; Koksal, Ekrem; Keles, Ali; Esen, Haci HasanThe purpose of this animal study was to evaluate the effects of hawthorn (Crataeus orientalis M Bieber.) extract on serum oxidative status and alveolar bone loss in experimental periodontitis. Twenty-seven Wistar rats were assigned to one of the following groups: nonligated+placebo (saline) (NL, n = 9), ligature only+placebo (saline) (LO, n = 9), and ligature and treated with hawthorn extract in saline (H, n = 9) (100 mg/kg orogastrically, once a day for 11 days). Periodontitis was induced by submerging a 4/0 silk ligature in the sulcus of the mandibular right first molars of rats, and the animals were sacrificed after 11 days. Micro-CT examinations were performed for linear and volumetric parameter assessment of alveolar bone. Periodontal tissues were histopathologically examined to assess the differences among the study groups. Levels of serum total antioxidant status (TAS)/total oxidant status (TOS), and oxidative stress index (OSI) were also analyzed. Alveolar bone loss was significantly reduced by hawthorn administration compared to LO group (p<0.05). The number of inflammatory cells and osteoclasts in the LO group was significantly higher than that of the NL and H groups (p<0.05). The number of osteoblasts in the LO and H groups was significantly higher than that of the NL group (p<0.05). TOS and OSI levels were significantly reduced in H group compared to LO group (P < 0.05) and TAS levels were similar in H and NL group (p < 0.05). Hawthorn extract showed inhibitory effect on periodontal inflammation and alveolar bone loss by regulating TAS, TOS and OSI levels in periodontal disease in rats when administered systemically.Öğe The Effectiveness of Crataegus orientalis M Bieber. (Hawthorn) Extract Administration in Preventing Alveolar Bone Loss in Rats with Experimental Periodontitis(Public Library Science, 2015) Hatipoglu, Mukerrem; Saglam, Mehmet; Koseoglu, Serhat; Koksal, Ekrem; Keles, Ali; Esen, Haci HasanThe purpose of this animal study was to evaluate the effects of hawthorn (Crataeus orientalis M Bieber.) extract on serum oxidative status and alveolar bone loss in experimental periodontitis. Twenty-seven Wistar rats were assigned to one of the following groups: nonligated+placebo (saline) (NL, n = 9), ligature only+placebo (saline) (LO, n = 9), and ligature and treated with hawthorn extract in saline (H, n = 9) (100 mg/kg orogastrically, once a day for 11 days). Periodontitis was induced by submerging a 4/0 silk ligature in the sulcus of the mandibular right first molars of rats, and the animals were sacrificed after 11 days. Micro-CT examinations were performed for linear and volumetric parameter assessment of alveolar bone. Periodontal tissues were histopathologically examined to assess the differences among the study groups. Levels of serum total antioxidant status (TAS)/total oxidant status (TOS), and oxidative stress index (OSI) were also analyzed. Alveolar bone loss was significantly reduced by hawthorn administration compared to LO group (p<0.05). The number of inflammatory cells and osteoclasts in the LO group was significantly higher than that of the NL and H groups (p<0.05). The number of osteoblasts in the LO and H groups was significantly higher than that of the NL group (p<0.05). TOS and OSI levels were significantly reduced in H group compared to LO group (P < 0.05) and TAS levels were similar in H and NL group (p < 0.05). Hawthorn extract showed inhibitory effect on periodontal inflammation and alveolar bone loss by regulating TAS, TOS and OSI levels in periodontal disease in rats when administered systemically.Öğe Expression of endocan and vascular endothelial growth factor and their correlation with histopathological prognostic parameters in pheochromocytoma(Springer, 2023) Kocabas, Muhammet; Can, Mustafa; Karakose, Melia; Esen, Haci Hasan; Kulaksizoglu, Mustafa; Karakurt, FeridunObjectiveEndocan and vascular endothelial growth factor (VEGF) are markers expressed in various cancer types that are highly vascular, and they have prognostic significance for these cancers. In this study, we aimed to show the expression of endocan and VEGF in pheochromocytoma tumor tissues and to evaluate their correlations with histopathological parameters.Material and methodsThirty-eight patients who had been operated for pheochromocytoma were included in the study. As the control group, 28 subjects whose specimens contained normal adrenal medulla tissue were included. The formalin-fixed paraffin-embedded specimens of pheochromocytoma patients were evaluated for Pheochromocytoma of the Adrenal gland Scaled Score (PASS). Sections were then stained for immunohistochemical analysis. The degree of endocan and VEGF positivity was determined by the proportion of stained cells on a negative to strong scale.ResultsEndocan (p < 0.001) and VEGF (p = 0.004) expressions were found to be significantly higher in the pheochromocytoma group than in the control group. In the pheochromocytoma group, total PASS score (r = 0.714; p < 0.001) and most of the PASS score components were positively correlated with the level of endocan expression. Median Ki-67 index (p = 0.010), total PASS score (p < 0.001), tumor cell spindling (p = 0.048), and nuclear pleomorphism (p = 0.030) were higher in pheochromocytoma with VEGF expression than in those without.ConclusionIf our findings are supported by studies with a larger sample size, we think that endocan has the potential to be used both as a tumor marker and in predicting malignancy potential in patients with pheochromocytoma, and that the detection of VEGF expression in these tumors is also associated with an increase in malignancy potential.Öğe Expression of the angiogenesis markers endocan in Cushing's syndrome due to cortisol producing adenoma(Springer, 2023) Can, Mustafa; Kocabas, Muhammet; Karakose, Melia; Esen, Haci Hasan; Kulaksizoglu, Mustafa; Karakurt, FeridunPurpose In this study, we aimed to investigate the endocan expression in tissue samples of patients diagnosed with Cushing's syndrome (CS) due to Cortisol-Producing-Adenoma (CPA) and compare it with normal adrenal cortex tissue, and also to evaluate the correlations of endocan expression with clinical and histopathological features. Methods 11 patients who were operated for CS due to CPA between 2009-2021 and 14 control subjects with normal adrenal cortex were included in the study. Demographic, laboratory and clinicopathological data of the patients were recorded. Sections of 4-5 mu m thickness were taken from paraffin blocks of patients diagnosed with CS due to CPA and control subjects with normal adrenal cortex tissue. The sections were then stained in a closed system automatic immunohistochemical staining device to perform immunohistochemical analysis. The endocan positive grade were determined based on the proportion of stained cells on a scale of negative to strong. Results The number of subjects with positive endocan expression and the mean endocan expression level in the CS group were significantly higher than the control group (p = 0.005, p < 0.001, respectively). No correlation was found between endocan expression and clinical and histopathological features. Conclusion According to the results of our study, endocan overexpression in CPA tissues may be related to the hormonal functionality of CPA.Öğe Histopathological Analysis in Testicular Tumors: 10 Years of Experience(Sage Publications Inc, 2023) Kilinc, Fahriye; Tas Aycicek, Seda; Esen, Haci HasanIntroduction. This study aims to review the morphological and immunohistochemical features of testicular tumors and compare them with prognostic parameters. Methods. Testicular tumors diagnosed between January 2011 and September 2021 were reviewed. Patient age, tumor subtype, size, spread, lateralization, number of foci, and immunohistochemical results were recorded. Results. A total of 121 tumors were detected, of which 108 (89%) were germ cell tumors (GCTs). Of the germ cell tumors, 70 (65%) were found to be pure type, and 38 (35%) were mixed germ cell tumors. The ratio of pure seminoma among GCTs was 56/108 (52%). Lymphatic/vascular invasion (LVI) was detected in 48/121 (40%), rete testis invasion in 32/121 (26%), hilar soft tissue invasion in 10/121 (8%), epididymal invasion in 5/121 (4%), and spermatic cord invasion in 5/121 (4%) patients. Lymphatic/vascular invasion was observed in 6 (22%) of 27 germ cell tumors smaller than 3 cm in size, and rete testis invasion was observed in 2 (7%), while in 40 (55%) of the 73 germ cell tumors of 3 cm and above, lymphatic/vascular invasion was seen, and 26 (36%) of them had rete testis invasion. Immunohistochemical results contributed significantly to the determination of tumor components and rates, especially in mixed germ cell tumors. Conclusion. Most of the tumors were germ cell tumors, and the majority were seminomas. Lymphatic/vascular invasion and rete testis invasion rates increase as the tumor diameter increases, which is more evident when the 3 cm cut-off value is taken into account (P < 0.005).Öğe Incidental Neuroendocrine Carcinoma of the Gallbladder(Modestum Ltd, 2014) Gundes, Ebubekir; Kucukkartallar, Tevfik; Cakir, Murat; Gemici, Kazim; Esen, Haci HasanGallbladder cancer is rare and adenocarcinoma usually seen. Neuroendocrine carcinomas are rare in malignancies. Generally diagnosis is not made in the pre-operative period. They are generally diagnosed after cholecystectomy through hystopathological examination. In this type of tumors primary treatment is surgical and cure can only be through a complete surgical resection. The histopathological examination of the neuroendocrine carcinoma after laparoscopic cholecystectomy in a patient wanted to present the report. This is about the treatment of cancers, certain drugs used for chemotherapy after surgery. The patient's 32-month follow-up of any problems encountered.Öğe Incidental Neuroendocrine Carcinoma of the Gallbladder(Modestum Ltd, 2014) Gundes, Ebubekir; Kucukkartallar, Tevfik; Cakir, Murat; Gemici, Kazim; Esen, Haci HasanGallbladder cancer is rare and adenocarcinoma usually seen. Neuroendocrine carcinomas are rare in malignancies. Generally diagnosis is not made in the pre-operative period. They are generally diagnosed after cholecystectomy through hystopathological examination. In this type of tumors primary treatment is surgical and cure can only be through a complete surgical resection. The histopathological examination of the neuroendocrine carcinoma after laparoscopic cholecystectomy in a patient wanted to present the report. This is about the treatment of cancers, certain drugs used for chemotherapy after surgery. The patient's 32-month follow-up of any problems encountered.Öğe The influence of rifamycin decontamination on incorporation of autologous onlay bone grafts in rats: A histometric and immunohistochemical evaluation(Pergamon-Elsevier Science Ltd, 2015) Tasdemir, Ufuk; Ozec, Ilker; Esen, Haci Hasan; Avunduk, M. CihatObjective: Although it has been shown that rifamycin is an effective agent for bone graft decontamination, no information exists on the effects of rifamycin decontamination on bone graft incorporation. The aim of this study was to evaluate the influence of rifamycin decontamination on the incorporation of autologous onlay bone grafts quantitatively. Design: In 30 rats, a standardized 5.0-mm-diameter bone graft was harvested from the right mandibular angle, contaminated with saliva, decontaminated with rifamycin solution, and augmented to the left as an onlay graft. Ten animals were sacrificed at 7, 14, and 21 days after surgery. In the control group (10 rats), the onlay grafts were neither contaminated nor decontaminated, and the rats were sacrificed at 21 days after surgery. Histological slides were prepared from each grafted site for both immunohistochemistry analysis (bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) antibodies) and histometric analysis. Images obtained from the graft incorporation area with the light microscope were transferred to a PC, and theywere evaluated using Clemex PE 3.5 image analysis software. Results: The grafts were fully incorporated in all specimens. The results showed that rifamycin decontamination has no detrimental effect on graft incorporation and the findings revealed a tendency for earlier revascularization and osteogenesis in the decontamination group. Data were analyzed using variance analysis and Tukey's test. Conclusions: Rifamycin decontamination has no detrimental effect on autogenous graft incorporation, and it can be used for graft decontamination with confidence. (C) 2014 Elsevier Ltd. All rights reserved.Öğe Invasive papillary carcinoma of the male breast(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2016) Gundes, Ebubekir; Aksoy, Faruk; Vatansev, Celalettin; Esen, Haci Hasan; Bal, AliBreast cancer is rarely seen in male patients. All the histological types of female breast cancer can be seen in male patients. Invasive papillary carcinoma is a rare breast cancer type. We hereby report the case of a 67-year-old male patient who underwent modified radical mastectomy because of invasive papillary carcinoma. The patient presented to our clinic with the complaint of a painless mass in his right breast. Tru-cut biopsy guided by imaging was performed. The pathological results of the biopsy were in line with invasive papillary carcinoma. We performed modified radical mastectomy on the patient. No recurrences were seen in the 24-month follow-up period.Öğe Isolated Esophageal Involvement in Pemphigus Vulgaris Confused with Esophageal Cancer(Istanbul Training & Research Hospital, 2019) Daye, Munise; Temiz, Selami Aykut; Asil, Mehmet; Esen, Haci HasanPemphigus is a disease characterized by the formation of intraepithelial blisters due to acantholysis caused by immunoglobulin G antibodies against the keratinocyte cell surface holding the mucous membranes and skin. While the oral mucosa is the most affected region, all body cells with multilayered horizontal epithelia such as the conjunctiva, pharynx, larynx, esophagus, vagina, penis, and anus might be affected. Although few pemphigus cases with esophageal involvement have been reported, the incidence of actual involvement is thought to be higher. Our case was guided by an external endoscopy center because of the appearance of esophagus cancer. This pre-diagnosis was excluded in the endoscopic biopsy, and lesions regressed entirely with the treatment given for pemphigus. The co-existence of pemphigus vulgaris and esophagus squamous cell carcinoma has been reported. However, it has not been previously reported that the esophageal involvement of pemphigus, as in our case, has been confused with esophageal cancer. In this case report, we present a pemphigus case with isolated esophageal involvement in a pemphigus patient in clinical remission. We found it worthy of presentation because of the confusion with esophageal cancer due to an endoscopy result from an external center.Öğe Local effects of epidermal growth factor on the wound healing in esophageal anastomosis: An experimental study(Elsevier Ireland Ltd, 2017) Adam, Ayse Bulbul; Ozdamar, Mustafa Yasar; Esen, Haci Hasan; Gunel, EnginObjective: In this study with the experimental model of primary repair of esophageal atresia(EA), we investigated the effects of the epidermal growth factor(EGF) on wound healing in the anastomosis of EA. Materials and methods: Forty rabbits that were performed a resection of a 1-cm segment of the cervical esophagus followed by the end-to-end anastomosis were divided into four groups. Group I (7-day group) and III (21-day group), the control groups, had no EGF applied to the anastomosis. In group II (7-day group) and group III (21-day group), all around the anastomoses were locally covered with 100 mu g/kg EGF. Group 1, 2 and 3, 4 were sacrificed on the 7th and 21st day, respectively. We investigated and compared with bursting pressure, vascularization around the anastomotic line by histopathology, inflammation, and fibroblast granulation as well as hydroxyproline level by biochemical. Results: No significant difference was found at vascularization and inflammation between all of the groups (p > 0.05). Considering the critical parameters of the groups, at bursting pressure difference was found between group 1 and 2 as well as 3 and (p < 0.05). At fibroblast granulation and hydroxyproline level, no difference was found between group 1 and 2 (p > 0.05) but the difference between group 3 and 4 (p < 0.05). Conclusion: EGF might be useful in preventing anastomotic leakage of esophageal atresia in primary anastomosis of esophageal atresia by accelerating wound healing process and increasing the stability of the anastomotic line. (C) 2017 Elsevier B.V. All rights reserved.Öğe Psoas Abscess Accompanied by Neonatal Appendicitis: A Case Report(Dr Behcet Uz Cocuk Hastaliklari Ve Cerrahisi, 2019) Yucel, Mehmet; Yilmaz, Fatma Hilal; Tarakci, Nuriye; Gultekin, Nazli Dilay; Altunhan, Huseyin; Esen, Haci HasanNeonatal appendicitis is a very rare event leading to acute abdomen manifestation in neonatal period, and is associated with high mortality rates. In these patients, symptoms and findings are not apparent, most of the time, urgent surgery is carried out without preoperative diagnosis; and diagnoses are made with intraoperative findings or pathological results. In the present case, a case with neonatal appendicitis that had psoas abscess with swelling and circulatory disorder in the right leg on the 15th day of life is presented.
