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    Acute Dystonia After Low-Dose Sertraline Treatment A Case Presentation and Review of the Literature
    (Lippincott Williams & Wilkins, 2023) Erden, Semih; Ferahkaya, Hursit
    [Abstract Not Availabe]
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    Claudin-5, occludin, zonulin and tricellulin levels of children with attention-deficit/hyperactivity disorder
    (Elsevier Espana Slu, 2024) Ferahkaya, Hursit; Akca, Omer Faruk; Baysal, Tamer; Kilinc, Ibrahim
    Background and objectives: Accumulating studies have pointed out that gut-blood and blood -brain barrier dysfunctions due to the alterations in permeability may play a role in the patho-physiology of neurodevelopmental disorders. Tight junctions are crucial components of these barriers and some peptides including claudin-5, occludin, zonulin and tricellulin are important components of these structures. This study aimed to investigate the relationship between these molecules and attention deficit hyperactivity disorder (ADHD) in children and adolescents.Methods: A total of 57 children with ADHD and 60 controls aged between 6 and 12 years were included in the study. The severity of ADHD symptoms was assessed through a parent-rated questionnaire, and Conner's Continuous Performance Test was administered to the study group. Serum levels of biochemical variables were measured using enzyme-linked immunosorbent assay kits. Biochemical parameter levels and scale scores were compared using Mann-Whitney U or Student's t tests. In addition, a multivariate analysis of covariance (MANCOVA) and a one-way analysis of covariance (ANCOVA) was performed on the outcome variables. Finally, a hierarchical regression model was conducted on the study group.Results: Serum claudin-5 and tricellulin levels were significantly lower in the ADHD group compared to the control group. The difference between the groups in terms of serum claudin-5 and tricellulin levels remained significant after controlling for confounding factors such as age, gender and autistic characteristics. There was no significant difference between the groups in terms of serum zonulin and occludin levels.Conclusion: These results reveal that claudin-5 and tricellulin levels vary in patients with ADHD. Alterations in these peptides may affect the brain by leading to a dysregulation in intestinal or blood-brain barrier permeability. The causal relationship between these peptides and ADHD requires further investigation.(c) 2023 Sociedad Espanola de Psiquiatna y Salud Mental. Published by Elsevier Espana, S.L.U. All rights reserved.
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    Excessive Masturbation Successfully Treated With Methylphenidate in a 6-Year-Old Child With Autism Spectrum Disorder Accompanied by Attention Deficit Hyperactivity Disorder
    (Lippincott Williams & Wilkins, 2021) Ferahkaya, Hursit; Bilgic, Ayhan
    Children with autism spectrum disorder frequently exhibit inappropriate sexual behaviors, such as excessive masturbation. However, research on the control and management of excessive masturbation in these children is very limited. In this presentation, excessive masturbation that responded to treatment with methylphenidate is described in a young boy diagnosed with autism spectrum disorder and comorbid attention deficit hyperactivity disorder.
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    Methylphenidate-Associated Syncope A Case Report
    (Lippincott Williams & Wilkins, 2022) Ferahkaya, Hursit; Uzun, Necati
    [Abstract Not Availabe]
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    Oculogyric Crisis Due to Low-Dose Olanzapine: A Case Report
    (Lippincott Williams & Wilkins, 2021) Erden, Semih; Ferahkaya, Hursit
    Objectives: Oculogyric crisis is a dystonic movement disorder characterized by continuous contraction of the ocular muscles and spasmodic movements of the pupils in a fixed position, usually upward. Methods: In this case report, an early-stage acute oculogyric crisis due to low-dose olanzapine in a 15-year-old adolescent boy is presented. Results: To the best of our knowledge, this is the first report showing that acute oculogyric crisis can develop with low-dose olanzapine administration. Conclusions: Even though second-generation antipsychotics are safer than conventional antipsychotics in terms of extrapyramidal adverse effects, this possibility should always be taken into consideration through this case report.
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    Serum Brain-Derived Neurotrophic Factor, Glial-Derived Neurotrophic Factor, Nerve Growth Factor and Neurotrophin-3 Levels in Preschool Children with Language Disorder
    (Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2021) Bilgic, Ayhan; Ferahkaya, Hursit; Kilinc, Ibrahim; Energin, Meryem Vesile
    Introduction: Accumulating studies demonstrate that neurotrophins may play a crucial role in a variety of neurodevelopmental disorders. However, little data are available regarding the potential role of neurotrophins in language disorder (LD). This study aimed to investigate serum brain-derived neurotrophic factor (BDNF), glialderived neurotrophic factor (GDNF), nerve growth factor (NGF) and neurotrophin-3 (NTF3) levels in preschool children with LD. Methods: A total of 43 cases with LD and 43 healthy controls aged 18 to 60 months were enrolled in the study. The development levels and psychiatric symptoms of the children were determined by the Ankara Developmental Screening Inventory and Child Behavior Checklist 1.5-5, respectively. Serum neurotrophin levels were assessed by enzyme-linked immunosorbent assay kits. Results: Serum GDNF and NGF levels were significantly higher, serum BDNF and NTF3 levels were significantly lower in the LD group than in the control group. However, with logistic regression analyses, only negative relationship of BDNF and NTF3 levels with the presence of LD remained significant after accounting for the confounders including development level and coexisting psychiatric symptoms. Conclusions: These results suggest that low BDNF and NTF3 levels have independent negative relationships with LD, which could be contribute to etiopathogenesis of the disorder.
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    Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder
    (Taylor & Francis Ltd, 2023) Bilgic, Ayhan; Ferahkaya, Hursit; Karagoez, Huelya; Kilinc, Ibrahim; Energin, Vesile Meltem
    Aim Increased intestinal and blood-brain barriers (BBB) permeability has been suggested to have a role in autism spectrum disorder (ASD). Claudin-5, claudin-11, occludin, beta-catenin, vinculin, and paxillin are crucial components of these barriers. This study assessed concentrations of these molecules in preschool children with ASD.Methods A total of 80 children with ASD and 40 controls aged 18-60 months were enrolled in this study. Serum levels of biochemical variables were determined using commercial enzyme-linked immunosorbent assay kits.Results Serum claudin-11, occludin, and beta-catenin levels were significantly higher in the ASD group than in the control group. However, no significant difference for serum claudin-5, vinculin, and paxillin levels was detected between the groups.Conclusion These findings suggest that claudin-11, occludin, and beta-catenin may be involved in the pathogenesis of ASD. These proteins may affect the brain by causing dysregulation in intestinal or blood-brain barrier permeability or with other unknown mechanisms.