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    Alterations of the thioredoxin system during subarachnoid hemorrhage-induced cerebral vasospasm
    (Springer Wien, 2015) Kaya, B.; Erdi, F.; Kilinc, I.; Keskin, F.; Feyzioglu, B.; Esen, H.; Karatas, Y.
    The exact underlying pathogenic mechanisms and effective preventive or therapeutic interventions for cerebral vasospasm remain obscure. The thioredoxin (Trx) system performs important functions in the central nervous system including neurotrophic and neuroprotective actions. There is no study directly investigating the effects of subarachnoid hemorrhage (SAH) induced cerebral vasospasm on the Trx system in the literature. Sixteen male New Zealand rabbits were randomly divided into two groups of eight rabbits each: a control group and a SAH group. The control group, (n = 8) was a sham surgery group in which SAH was not induced. In the SAH group, (n = 8), the SAH protocol was used to induce cerebral vasospasm. The brain and brainstem were removed and each brainstem was cut coronally into two pieces: an anterior part that contains basilar artery and a dorsal part that contains brainstem tissue. The brainstem tissue thioredoxin-1(Trx1), thioredoxin-2 (Trx2), thioredoxin reductase (TrxR), thioredoxin reductase-1 (TrxR1), thioredoxin-interacting protein (TXNIP) levels were investigated. Total oxidant status (TOS), total antioxidant status (TAS), malondialdehyde levels (MDA) and tumor necrosis factor alpha (TNF-alpha) levels were investigated for determining the oxidative-antioxidative status of the related brain tissues. Basilar artery segments were investigated for cross-sectional area and wall thickness measurements. SAH statistically significantly reduced the tissue levels of Trx1 (p < 0.01) and TrxR (p < 0.01). Trx2 levels were not significantly altered after SAH (p > 0.05). SAH significantly reduced the expression of TrxR1 (p < 0.01) and significantly increased the expression of TXNIP (p < 0.01) when compared with controls. TOS levels and MDA levels significantly increased after SAH (p < 0.01) and TAS levels significantly reduced after SAH (p < 0.01). TNF-alpha levels significantly increased after SAH (p < 0.01). SAH-induced cerebral vasospasm significantly (p < 0.05) increased the wall thickness and reduced the mean cross-sectional area of the basilar artery (p < 0.05). The Trx system seems to be negatively affected by the simultaneously interrelated enzymatic alterations during cerebral vasospasm.
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    Comparison of the diagnostic values in rheumatoid arthritis: Anti-CCP antibodies and other serological tests
    (Allied Acad, 2014) Dogan, M.; Kucuksarac, S.; Tufekci, O.; Feyzioglu, B.; Ozdemir, M.; Baykan, M.; Baysal, B.
    Rheumatoid arthritis (RA) is an inflammatory autoimmune disease. Early diagnosis, early and aggressive treatment are the best means of avoiding joint destruction, organ damage and disability. This prospective study was carried out to determine the relationship between RA and laboratory tests used in the diagnosis of RA. 199 patients (20 males, 179 females; mean age: 50.6 years) that were suspected to be RA were included in the study. Anti-CCP, RF, ESR, and CRP tests were performed for all patients. The patients were divided two groups named RA and non-RA according to American College of Rheumatology criteria. Of the all patients, 96(48.2%) tested as positive for anti-CCP antibodies. Of the RA patients, 93 (68.9%) were positive for anti-CCP antibodies. The positivity of anti-CCP antibodies was 4.7% (3/64) for non-RA. Sensitivity, specificity, PPV, and NPV in diagnosis of RA for anti-CCP respectively were 0.69, 0.95, 0.97, and 0.59, and for high positive anti-CCP respectively were 0.55, 1.00, 1.00, and 0.52, and for RF respectively were 0.59, 0.92, 0.94, and 0.52, and for high positive RF respectively were 0.54, 0.98, 0.99, and 0.54, and for CRP respectively were 0.73, 0.78, 0.87, and 0.57, and for ESR respectively were 0.84, 0.30, 0.72, and 0.46. Sensitivity for the diagnosis of RA could be further increased by a combination of the anti-CCP and RF tests. There was a positive correlation between anti-CCP and RF positivity (Phi=0.59537), anti-CCP and RF high positivity (Phi=0.537364), ESR and CRP (Phi=0.426544). It is concluded that performing anti-CCP test in the diagnosis of RA could be beneficial since it has high specificity and positive predictive value. If this test was performed together with RF, it may be more beneficial.