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Öğe Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues(Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2018) Aricigil, Mitat; Dundar, Mehmet Akif; Yucel, Abitter; Arbag, Hamdi; Arslan, Abdullah; Aktan, Meryem; Findik, SidikaIntroduction: To manage the complications of irradiation of head and neck tissue is a challenging issue for the otolaryngologist. Definitive treatment of these complications is still controversial. Recently, hyperbaric oxygen therapy is promising option for these complications. Objective: In this study, we used biochemical and histopathological methods to investigate the efficacy of hyperbaric oxygen against the inflammatory effects of radiotherapy in blood and laryngeal tissues when radiotherapy and hyperbaric oxygen are administered on the same day. Methods: Thirty-two Wistar Albino rats were divided into four groups. The control group was given no treatment, the hyperbaric oxygen group was given only hyperbaric oxygen therapy, the radiotherapy group was given only radiotherapy, and the radiotherapy plus hyperbaric oxygen group was given both treatments on the same day. Results: Histopathological and biochemical evaluations of specimens were performed. Serum tumor necrosis factor-alpha, interleukin-1 beta, and tissue inflammation levels were significantly higher in the radiotherapy group than in the radiotherapy plus hyperbaric oxygen group, whereas interteukin-10 was higher in the radiotherapy plus hyperbaric oxygen group. Conclusion: When radiotherapy and hyperbaric oxygen are administered on the same day, inflammatory cytokines and tissue inflammation can be reduced in an early period of radiation injury. (C) 2017 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.Öğe Measurement of Epidermis, Dermis, and Total Skin Thicknesses from Six Different Body Regions with a new Ethical Histometric Technique(Wolters Kluwer Medknow Publications, 2018) Oltulu, Pembe; Ince, Bilsev; Kokbudak, Naile; Findik, Sidika; Kilinc, FahriyeIntroduction: Although it is important to know the normal values of dermis, epidermis, or total skin thicknesses (ST) for some drugs and vaccine research, skin-related clinical investigations, and skin transfer operations used in plastic surgery, it would not be ethical to take new biopsies from healthy volunteers to measure their ST. This study aims to describe a new ethical histometric technique for the measurement of skin layers and to determine the mean ST of some major body regions in the people living in our region. Materials and Methods: A total of 180 skin samples from six major body regions of 90 males and 90 females were enrolled in the study. The measurements were performed histometrically from appropriate skin samples obtained from the pathology archive. The samples were classified according to the six different parts of the body (scalp, abdomen, back, dorsum of foot, dorsum of hand, and the breast). Results: The mean epidermal thickness ranged from 76.9 +/- 26.2 to 267.4 +/- 120.6 mu m. The thickest epidermis was found in the dorsum of foot in women (267.4 +/- 120.6 mu m) while the thinnest was found in the breast in women (76.9 +/- 26.2 mu m). The mean dermal thickness ranged from 2115 +/- 946.4 to 5888 +/- 2422.3 mu m. The thickest dermis was found in the breast in men (5888 +/- 2422.3 mu m), while the thinnest dermis was found in the dorsum of hand in women (2115 +/- 946.4 mu m). Conclusions: Human ST varies according to ethnic origin. It was determined that the dermis and epidermis of Anatolian people are thicker than that of the previously reported other ethnic groups. The skin pathology archive can be used to create maps of the body's skin structure.Öğe Melatonin prevents possible radiotherapy-induced thyroid injury(Taylor & Francis Ltd, 2017) Aricigil, Mitat; Dundar, Mehmet Akif; Yucel, Abitter; Eryilmaz, Mehmet Akif; Aktan, Meryem; Alan, Mehmet Akif; Findik, SidikaPurpose: We aimed to investigate the protective effect of melatonin in radiotherapy-induced thyroid gland injury in an experimental rat model.Materials and methods: Thirty-two rats were divided into four groups: the control group, melatonin treatment group, radiotherapy group and melatonin plus radiotherapy group. The neck region of each rat was defined by simulation and radiated with 2 Gray (Gy) per min with 6-MV photon beams, for a total dose of 18Gy. Melatonin was administered at a dose of 50mg/kg through intraperitoneal injection, 15min prior to radiation exposure. Thirty days after the beginning of the study, rats were decapitated and analyses of blood and thyroid tissue were performed.Results: Tumor necrosis factor- (TNF-), interleukin-1 beta (IL-1), thiobarbituric acid reactive substances (TBARS) and nitric oxide (NO) levels in the radiotherapy group were significantly higher than those in the melatonin plus radiotherapy group (p<.05), whereas interleukin-10 (IL-10) and glutathione (GSH) values were higher in the melatonin plus radiotherapy group (p<.05). The infiltration of inflammatory cells and percentage of apoptosis in the radiotherapy group were significantly higher than those in the melatonin plus radiotherapy group (p<.05).Conclusions: Melatonin helped protect thyroid gland structure against the undesired cytotoxic effects of radiotherapy in rats.Öğe Our Clinical Experiences in Lower Eyelid Reconstruction(Wolters Kluwer Medknow Publications, 2018) Altuntas, Zeynep; Uyar, Ilker; Findik, SidikaObjective: Different treatment principles have been applied in the reconstruction of partial or full layer defects of the lower eyelid. The use of the most similar tissue for eyelid reconstruction is important for both functional and esthetic results. This study aims to investigate the reconstruction methods performed in lower eyelid defects and to evaluate their esthetic and functional results. Patients and Methods: In this study, patients who underwent reconstructive surgery from 2012 to 2016 in our clinic were investigated. Cases of primary repairs after skin tumors located in the lower eyelids were excluded from the study. The sociodemographic characteristics of patients, the type and location of the tumor, defect size after surgery, anterior and posterior lamellar defects, and reconstruction methods used were retrospectively reviewed. Results: Thirty-seven patients were included in the study. Fifteen were male and 22 were female. There was only anterior lamellar defect in 29 patients and full-thickness lower eyelid defect in 8 patients. Anterior flaps used in lamellar defects were identified as glabellar flap, Limberg flap, advancement, transposition flap, nasolabial flap, forehead flap, and cheek flap. Chondromucosal graft, palatal mucosal graft, and buccal mucosal graft were used for repairing posterior lamellar defects. Conclusion: Separate reconstruction of the posterior and anterior lamellae is important to provide good functional and esthetic results in lower eyelid reconstruction. Depending on the size of the defect, using a single local flap or a combined flap with posterior lamella repair provides highly acceptable results.Öğe Prenatal Diagnosis and Intrapartum Management of Congenital Ranula(Georg Thieme Verlag Kg, 2018) Ercan, Fedi; Sarikaya, Muslum; Toprak, Erzat; Findik, Sidika; Arbag, Hamdi; Acar, AliA foetal sublingual cystic lesion was diagnosed by routine prenatal ultrasonography at 27 weeks of gestation. Foetal growth and amniotic fluid volume were normal. An ex utero intrapartum treatment (EXIT) procedure was performed, and the cyst was aspirated to allow breathing during planned Caesarean section. The cyst was totally excised when the newborn was 60 days old, and histopathological examination revealed a mucous cyst of the mouth floor.Öğe Prognostic Value of IDH-1, PTEN and EGFR Expression in High Grade Gliomas(Akad Doktorlar Yayinevi, 2019) Aktan, Meryem; Findik, Sidika; Kanyilmaz, Gul; Yavuz, Berrin Benli; Koc, MehmetGliomas are the most common primary brain tumors in adults. Despite advances in modem diagnostic procedures and therapies, the prognosis is still poor. To improve survival and the knowledge about the biological and clinical presentation of gliomas, more individualised and targeted treatments are needed. The aim of this study was to correlate the immunostaining patterns of isocitrate dehydrogenase-1 (IDH-1), phosphatase and tensin homolog (PTEN) and epidermal growth factor (EGFR) with progression-free survival (PFS) and overall survival (OS) in high grade gliomas patients. We analized 60 high grade gliomas who underwent surgery and standard chemoradiotherapy. Immunohistochemical methods were used to classify the IDH-1 gene mutation presence, staining patterns of PTEN and EGFR in tumor samples of the diagnosis. Median follow-up time was 18.9 months. There was significant relation between IDH-1 mutation and OS. Median OS was 37.9 months for patients with IDH-1 mutation, 12.4 months for patients with no mutation (p< 0.001). Median PFS was 29.8 months for patients with no IDH-1 mutation and 70.4 months for patients with IDH-1 mutation (p= 0.03). There was no significant relation between PTEN and EGFR immunopattern and OS or PFS in univariate analysis. However, there was significant relation between immunoreactivity of PTEN and OS (p= 0.03), immunointensity of PTEN and OS (p= 0.02) in multivariate analysis. In conclusion, the relationship between EGFR mutation and OS and PFS can also be demonstrated by studies with more patients.Öğe The Prognostic Value of Serum Semaphorin3A and VEGF Levels in Patients with Metastatic Colorectal Cancer(Springer, 2020) Karpuz, Tuba; Araz, Murat; Korkmaz, Levent; Kilinc, Ibrahim; Findik, Sidika; Karaagac, Mustafa; Eryilmaz, Melek KarakurtPurpose Despite new treatment options in metastatic colorectal cancer (mCRC), new prognostic markers are still needed to determine optimal chemoregimen especially for anti-angiogenesis drugs. In this study, we evaluated the serum semaphorin and VEGF-A levels as prognostic factors in patients with mCRC. Methods Patients with diagnosed mCRC who were treated with first-line bevacizumab plus chemotherapy were included in the study. Venous blood samples of 37 patients with metastatic colon cancer were taken, and serum semaphorin 3A and VEGF-A levels were studied in pre-treatment and the 1st and third months after the treatment was initiated. Results Totally, 37 patients were enrolled in the study. The patients' mean age was 62 years. Twenty-eight (49%) of the patients were male, and 19 (51%) were female. Serum semaphorin3A (sema3A) levels of the patients were 5.4 +/- 7.4 ng/ml before the treatment, 3.5 +/- 3.3 ng/ml at the first month, and 3.5 +/- 3.7 ng/ml at the third month. Serum VEGF-A levels were 27.7 +/- 32.9 ng/l before the treatment, 23.1 +/- 28.1 ng/l at the first month, and 28.9 +/- 30.2 ng/l at the third month. There was no significant correlation between the survival and pre-treatment VEGF-A level (p = 0.064). Overall survival (OS) was statistically significantly higher in patients with pre-treatment semaphorin 3A levels below 5.4 ng/ml than higher than 5.4 ng/ml (10.5 months vs 4.5 months, respectively, HR 0.23, 95% CI 19.635-11,391, p = 0.012). Conclusion Pre-treatment semaphorin 3A level can be a prognostic marker for the mCRC patients who were treated with bevacizumab in patients with metastatic colorectal cancer.Öğe Prostate Involvement in a Patient with Follicular Lymphoma(Galenos Yayincilik, 2017) Yilmaz, Seda; Demircioglu, Sinan; Bektas, Ozlen; Ceneli, Ozcan; Findik, Sidika[Abstract Not Availabe]Öğe A rare case of gestational gigantomastia(Wiley, 2019) Karacor-Altuntas, Zeynep; Yildirim, Mehmet E. C.; Findik, Sidika[Abstract Not Availabe]
