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Öğe Antipsychotic-Induced Drug Rash With Eosinophilia and Systemic Symptoms Syndrome: A Case Report(Lippincott Williams & Wilkins, 2021) Gica, Sakir; Elmaci, Zeynep Celile; Balaban, Ozlem Devrim; Karamustafalioglu, Nesrin[Abstract Not Availabe]Öğe Approach to COVID-19 vaccine hesitancy based on some psychological symptoms and attachment theory: A web-based community survey(Kare Publ, 2023) Gica, Sakir; Sahingoz, Mine; Tanriverdi, Esra CinarObjective: The aim of this study is to investigate the effects of psychiatric symptoms such as anxiety, obsession, hostility, and attachment styles, which may be associated with COVID-19 vaccine hesitancy.Method: A total of 504 adult participants were included in the study. The sociodemographic data form, including questions on information about participants' COVID-19 infection history and concerns about COVID-19 vaccines, was filled out by the participants. The participants were evaluated with the anxiety, obsessive-compulsive disorder (OCD), hostility, and paranoid ideation subscales of the Symptom Checklist - Revised 90 scale and the Adults Attachment Style Scale (AASS). The participants were divided into three groups: vaccinated group (VG), nonvaccinated but intend to get vaccinated group (IGV), and nonvaccinated group and not intend to get vaccinated group (NIGV).Results: The mean score of the AASS secure subscale was higher (p=0.009), while the SCL-90 anxiety subscale was lower (p=0.003) in the NIGV group. The mean score of the SCL-90 OCD subscale in the NIGV group was lower than that in the IGV group (p=0.040). Regression analysis showed that concerns about the safety of vaccines (OR: 140, p<0.001) and having secure attachment style (OR: 1.787, p=0.019) increase the intention to not be vaccinated. However, it was found that high anxiety scores decreased the intention not to be vaccinated (OR: 0.966, p=0.035).Conclusion: The findings of the current study indicate that secure attachment style and clinical psychiatric entities such as anxiety and obsession were effective on vaccine hesitancy. However, this interaction needs to be interpreted carefully in the context of the perceived level of COVID-19 threat, more detailed information about the safety and necessity of vaccines, the relationship of individuals with their social environment, and the predominance of vaccine hesitancy in their social environment.Öğe Approach to COVID-19 vaccine hesitancy based on some psychological symptoms and attachment theory: A web-based community survey(Kare Publ, 2023) Gica, Sakir; Sahingoz, Mine; Tanriverdi, Esra CinarObjective: The aim of this study is to investigate the effects of psychiatric symptoms such as anxiety, obsession, hostility, and attachment styles, which may be associated with COVID-19 vaccine hesitancy.Method: A total of 504 adult participants were included in the study. The sociodemographic data form, including questions on information about participants' COVID-19 infection history and concerns about COVID-19 vaccines, was filled out by the participants. The participants were evaluated with the anxiety, obsessive-compulsive disorder (OCD), hostility, and paranoid ideation subscales of the Symptom Checklist - Revised 90 scale and the Adults Attachment Style Scale (AASS). The participants were divided into three groups: vaccinated group (VG), nonvaccinated but intend to get vaccinated group (IGV), and nonvaccinated group and not intend to get vaccinated group (NIGV).Results: The mean score of the AASS secure subscale was higher (p=0.009), while the SCL-90 anxiety subscale was lower (p=0.003) in the NIGV group. The mean score of the SCL-90 OCD subscale in the NIGV group was lower than that in the IGV group (p=0.040). Regression analysis showed that concerns about the safety of vaccines (OR: 140, p<0.001) and having secure attachment style (OR: 1.787, p=0.019) increase the intention to not be vaccinated. However, it was found that high anxiety scores decreased the intention not to be vaccinated (OR: 0.966, p=0.035).Conclusion: The findings of the current study indicate that secure attachment style and clinical psychiatric entities such as anxiety and obsession were effective on vaccine hesitancy. However, this interaction needs to be interpreted carefully in the context of the perceived level of COVID-19 threat, more detailed information about the safety and necessity of vaccines, the relationship of individuals with their social environment, and the predominance of vaccine hesitancy in their social environment.Öğe The association between neurocognitive functioning and clinical features of borderline personality disorder(Assoc Brasileira Psiquiatria, 2020) Kaplan, Bahar; Gulec, Medine Yazici; Gica, Sakir; Gulec, HuseyinObjective: To investigate the relationship between neurocognitive profiles and clinical manifestations of borderline personality disorder (BPD). Methods: Forty-five patients diagnosed with BPD and 35 healthy volunteers were included in the study. The BPD group was evaluated with the Borderline Personality Inventory for dissociative, impulsivity and suicidal dimensions. The Verbal Memory Processes Test and the Cambridge Neurophysiological Assessment Battery were administered to both the BPD and healthy control groups. Results: BPD patients differed from controls in sustained attention, facial emotion recognition, and deteriorated verbal memory function. A model consisting of the Dissociative Experiences Scale Taxon (DES-T), motor impulsivity and Scale for Suicidal Behavior scores explained 52% of the variance in Borderline Personality Inventory scores. It was detected that motor impulsivity, decision-making and recognizing sadness may significantly predict DES-T scores, and response inhibition and facial emotion recognition scores may significantly predict impulsivity. Conclusion: Our findings demonstrate that the disassociation, impulsivity, and suicidality dimensions are sufficient to represent the clinical manifestations of BPD, that they are related to neurocognitive differences, and that they interact with clinical features.Öğe The association between neurocognitive functioning and clinical features of borderline personality disorder(Assoc Brasileira Psiquiatria, 2020) Kaplan, Bahar; Gulec, Medine Yazici; Gica, Sakir; Gulec, HuseyinObjective: To investigate the relationship between neurocognitive profiles and clinical manifestations of borderline personality disorder (BPD). Methods: Forty-five patients diagnosed with BPD and 35 healthy volunteers were included in the study. The BPD group was evaluated with the Borderline Personality Inventory for dissociative, impulsivity and suicidal dimensions. The Verbal Memory Processes Test and the Cambridge Neurophysiological Assessment Battery were administered to both the BPD and healthy control groups. Results: BPD patients differed from controls in sustained attention, facial emotion recognition, and deteriorated verbal memory function. A model consisting of the Dissociative Experiences Scale Taxon (DES-T), motor impulsivity and Scale for Suicidal Behavior scores explained 52% of the variance in Borderline Personality Inventory scores. It was detected that motor impulsivity, decision-making and recognizing sadness may significantly predict DES-T scores, and response inhibition and facial emotion recognition scores may significantly predict impulsivity. Conclusion: Our findings demonstrate that the disassociation, impulsivity, and suicidality dimensions are sufficient to represent the clinical manifestations of BPD, that they are related to neurocognitive differences, and that they interact with clinical features.Öğe Can the Imbalance between Neurotrophic and Apoptotic Proteins Be the Beware the Ides of March for Unaffected Relatives of Schizophrenia Patients?(Springer, 2022) Yesilkaya, Umit Haluk; Gica, Sakir; Menekseoglu, Pelin Ozkara; Tasdemir, Busra Guney; Cirakli, Zeynep; Karamustafalioglu, NesrinSchizophrenia (SZ) is a mental disorder with a strong genetic basis as well as epigenetic aspects. Siblings of patients with SZ can share certain endophenotypes with the patients, suggesting that siblings may be important for distinguishing between trait and state markers. In the current study, we aimed to characterize the balance between pro-BDNF/mature BDNF and its receptors p75NTR/TrkB, which are tPA-BDNF pathways proteins and are thought to play a role in synaptic pruning, as a possible endophenotype of schizophrenia. Forty drug-naive patients with first-episode psychosis (FEP) matched for age, gender, and level of education, 40 unaffected siblings (UAS) of patients with FEP, and 67 healthy controls (HC) were included in the study. Blood samples were collected from all participants to determine BDNF, pro-BDNF, TrkB and p75NTR, PAI1, tPA, ACTH, and cortisol levels. We showed that levels of proteins of the tPA-BDNF pathway as well as the pro-BDNF/m-BDNF and p75NTR/TrkB ratios could successfully differentiate FEP and their siblings from the HCs by using ROC analysis. Plasma levels of m-BDNF were found to be the lowest in the healthy siblings and highest in the HCs with statistically significant differences between all 3 groups. The plasma level of pro-BDNF in the HC group was similar to the FEP patients, the same in the healthy siblings of the FEP patients. Our data support the hypothesis that imbalance between neurotrophic and apoptotic proteins might occur in SZ and this imbalance could be an endophenotype of the disease.Öğe The clinical correlation and predictive value of electrophysiological variables on clinical response to clozapine in patients with treatment-resistant schizophrenia(Elsevier, 2019) Gica, Sakir; Buyukavsar, Ahsen; Poyraz, Burc Cagri; Gulec, Huseyin[Abstract Not Availabe]Öğe Clozapine-Associated Stuttering: A Case Report(Lippincott Williams & Wilkins, 2020) Gica, Sakir; Kilic, Cenk; Karamustafalioglu, Nesrin[Abstract Not Availabe]Öğe Comparison of the Clinical and Treatment Characteristics of Patients Undergoing Electroconvulsive Therapy for Catatonia Indication in the Context of Gender(Sage Publications Inc, 2022) Parsanoglu, Zozan; Balaban, Ozlem Devrim; Gica, Sakir; Atay, Ozge Canbek; Altin, OzanThe aim of this study was to compare in the context of gender both clinical diagnosis and disease-related differences and electroconvulsive therapy (ECT)-related differences in data and efficacy in hospitalized patients with catatonic signs and symptoms. Data from 106 patients who received ECT with catatonia indication were retrospectively analyzed. Clinical data of male (n = 58) and female (n = 48) patients were compared. Hospitalization documents and outpatient files, sociodemographic and clinical data form, Clinical Global Improvement scores used by the ECT unit in the follow-up of patients who received ECT were used in the study. It was seen that the mean age of women at the onset of ECT was higher than in men and the presence of prolonged seizures was more common than men. In men, it was found out that the average number of sessions with the onset of clinical response to treatment was higher than the average of women. The distribution of diagnoses by gender showed that the presence of schizophrenia diagnosis in men and of bipolar disorder in women were significantly more frequent compared to the opposite sex. It was found out that there were no significant differences between genders in terms of response rate to ECT. Our study is important for being the first study in the literature investigating the gender differences in ECT used for catatonia. However, gender is not a distinctive factor in the effectiveness of treatment, there are some important differences between male and female patients showing signs and symptoms of catatonia and undergoing ECT.Öğe The effect of attention deficit hyperactivity disorder comorbidity on cognitive functions and severity of addiction in opioid use disorder(Routledge Journals, Taylor & Francis Ltd, 2021) Donmez, Zeliha; Gica, Sakir; Unubol, Basak; Iyisoy, M. Sinan; Gulec, HuseyinThe aim of this study is to determine the changes in social cognition and other cognitive domains in ADHD comorbidity and to investigate the possible moderation role of these changes in OUD. A hundered inpatients with OUD were included in the study. Cognitive functions, severity of addiction and symptomatology of ADHD were evaluated. ASRS and API scores were in positive correlation and ASRS scores had a moderating effect on the relationship between craving score and emotion recognition. Our study shows that changes in social environment/cognition play an important role in the follow-up/treatment of patients.Öğe The effect of chronotypes on follow-up outcomes of patients with substance use disorder(Springer Japan Kk, 2023) Ciner, Ozlem Akcay; Cilli, Ali Savas; Yazici, Ahmet Bulent; Bakay, Hasan; Gica, SakirSubstance use disorder (SUD) can have circadian characteristics and individuals with evening chronotype are more prone to addiction. In this study, the effect of chronotypes on the treatment outcomes of SUD was investigated. The study included 66 patients who were diagnosed with SUD according to DSM-5. Two clinical interviews were conducted at 6-month intervals, and remission/relapse status was evaluated at the second interview. The Structured Clinical Interview Form for DSM-IV Axis I Disorders (SCID-I), Addiction Profile Index Practitioner Form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Pittsburg Sleep Quality Index and Morningness-Eveningness Questionnaire (MEQ) were applied to the patients. MEQ scores of relapsed patients were found to be different in terms of eveningness than those in remission (45.62 +/- 8.70 versus 49.75 +/- 7.60, p = 0.045). As the craving and addiction profile index total scores (addiction severity) increased, eveningness chronotype scores also increased (r = - 0.387 and r = - 0.286, respectively). The mean scores of craving and BDI were higher in relapsed patients compared to those in remission (p = 0.003 and p = 0.015, respectively). Our results suggest that patients with SUD had a lower morningness chronotype than the general population; additionally, more relapsed patients had an eveningness chronotype. Thus, chronotypes may play a role in the onset, prevention, and treatment outcome of SUD.Öğe The Effect of COVID-19 Pandemic on Psychosomatic Complaints and Investigation of The Mediating Role of Intolerance to Uncertainty, Biological Rhythm Changes and Perceived COVID-19 Threat in this Relationship: A Web-Based Community Survey(Aves, 2020) Gica, Sakir; Kavakli, Mehmet; Durduran, Yasemin; Ak, MehmetBackground: The aim of the present study was to determine the increase in psychosomatic complaints during the COVID-19 pandemic and to identify the factors associated with psychosomatic complaints. Methods: Five-hundred and thirty-three participants were included in the study. The participants completed the following self-reported scales: Personal Information Form, Perceived COVID-19 Threat Form, Intolerance of Uncertainty Scale, Biological Rhythms Interview of Assessment in Neuropsychiatry and Patient Health Questionnaire-15 (PHQ-15). The data were gathered online. The participants filled PHQ-15 scale twice. In the one interrogation, they were asked to fill the scale according to the current time, and in the other interrogation, they were asked to retrospectively report their status before the COVID-19 outbreak started. Results: The psychosomatic symptom levels of the participants increased (M = 9.08, SD = 5.98) after the COVID-19 outbreak compared to before. The first and second PHQ scores were both positively related to perceived COVID-19 threat, intolerance of uncertainty and biological rhythms. However, the correlation coefficients of the second PHQ scores (after the outbreak) were higher than the first. Perceived COVID-19 threat predicted intolerance of uncertainty, but did not predict biological rhythms. The relationship between perceived COVID-19 threat and the present PHQ score was partially mediated by intolerance of uncertainty. Also, the relationship between perceived COVID-19 threat and present PHQ score were partially mediated by both intolerance of uncertainty and biological rhythms. Conclusion: Psychosomatic complaints were increased during the COVID-19 outbreak period, and the changes in perceived threat and biological rhythm, especially intolerance of uncertainty, were effective in this increase. Results of our study revealed the importance of including the patient's ability to tolerate uncertainty in therapeutic approaches during COVID-19 and similar pandemics. In addition, the importance of the attempt to protect the circadian rhythm in the quarantine process has been demonstrated once again in order to reduce mental influences of the COVID-19 outbreak.Öğe Effects of COVID-19 Pandemic on Psychological Condition and Disease Severity in Patients with Behcet's Disease(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2020) Kucuk, Adem; Vatansev, Hulya; Gica, Sakir; Demir, Salih; Cure, ErkanObjective: Behcet's disease (BD) is an episodic and chronic multisystemic disease. Many comorbid psychiatric disorders are frequently encountered in BD. In addition, it is reported that individuals with chronic diseases during the epidemic period are at risk for COVID-19 infection. Therefore, these situations may cause anxiety levels to increase and coping strategies to decrease overall psychological conditions in patients with BD. However, individuals with both psychiatric complaints and comorbid inflammatory and chronic diseases such as BD are more prone to this stressful situation than healthy individuals. In the current study, we aimed to determine whether patients with Behcet's Disease (BD) are psychologically more sensitive than healthy individuals and whether disease severity increase with the COVID-19 pandemic. Methods: One hundred and fifty-six patients with BD and 156 healthy volunteers were included in the study. All participants received Perceived COVID-19 Threat Form (PCTF), Suicide-Ideation Scale (SIS), Hospital Anxiety and Depression Scale (HADS), The Ability to Cope with Trauma (PACT), well-being index (PGWB) scales. Results: When the responses of the patient with BD and control groups to the psychiatric evaluation scales were examined; the mean scores of PCTF (p <0.001), SIS (p<0.001), HADS-depression (p<0.001) and HADS-anxiety (p<0.001) in patients with BD were significantly higher than the control group. Mean scores of PGWB (p<0.001) and PACT (p= 0.042) in the patient group were found to be lower. In the relationship analysis, BSAS scores were associated with PCTF scores (r=0.20, p=0.013), and PGWB scores were associated with PACT scores (r=0.53, p=0.001). Conclusion: COVID-19 pandemic affects the mental health of both male and female patients with BD significantly. In patients with BD, while disease severity was associated with the perceived COVID threat, psychological well-being was associated with existing psychiatric complaints and patients' ability to cope with trauma. The findings of our study support that patients with BD may need more psychological support than ever during the COVID-19 pandemic.Öğe Effects of the COVID-19 pandemic on psychology and disease activity in patients with ankylosing spondylitis and rheumatoid arthritis(Tubitak Scientific & Technological Research Council Turkey, 2021) Gica, Sakir; Akkubak, Yasemin; Aksoy, Zakire Kubra; Kucuk, Adem; Cure, ErkanBackground/aim: The COVID-19 outbreak is known to increase stress levels of most patients with chronic diseases. Patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are highly susceptible to environmental stress. In the current study, we aimed to determine how the COVID-19 pandemic psychologically affected patients with chronic progressive diseases such as AS and RA and the effects of these psychological factors on disease activity. Materials and methods: Age and sex-matched patients with AS (n = 80), RA (n = 80), and healthy controls (n = 80) were included in the study. All participants were evaluated with the Perceived COVID-19 Threat Form (PCTF), Suicide-Ideation Scale (SIS), Hospital Anxiety and Depression Scale (HADS), The Ability to Cope with Trauma (PACT), and Psychological General Well-Being Index (PGWB) scales. BASDAI was used in patients with AS, and DAS28 was used in patients with RA to assess disease severity. Results: Compared to healthy individuals, patients with RA and AS had lower PGWB scores and higher HADS depression and anxiety subscale scores. Almost all psychometric assessment test scores were worse in AS patients with high-disease activity compared to those in low-disease activity. PACT scores were higher in patients with moderate RA compared to patients with mild RA (p = 0.006). While a positive correlation was identified between BASDAI and most of the psychometric assessment test scores (r = 0 .36 for PCTF, r = 0.53 for depressive scores, r = 0.54 for anxiety scores, r = 0.57 for suicidal ideation), DAS28 scores were found to be associated only with PACT total and PACT perceived forward-focused subscale scores (r = -.26 and r = .33, respectively). Conclusion: Psychologically, AS and RA patients were found to be worse off compared to healthy controls. The perceived COVID threat and psychological status were associated with disease activity in AS, but not RA patients. Patients with chronic illnesses may be more vulnerable to the psychological effects of the pandemic, which can worsen disease activity.Öğe Emotional Information Processing and Assessment of Cognitive Functions in Social Anxiety Disorder: An Event-Related Potential Study(Sage Publications Inc, 2022) Tetik, Dilek; Gica, Sakir; Bestepe, Engin Emrem; Buyukavsar, Ahsen; Gulec, HuseyinThe aim of our study was to determine deficits in cognitive areas, including social cognition such as emotion recognition capacity, theory of mind, and electrophysiological alterations in patients with social anxiety disorder (SAD) and to identify their effects on clinical severity of SAD. Enrolled in our study were 26 patients diagnosed with SAD and 26 healthy volunteers. They were administered the Liebowitz Social Anxiety Scale (LSAS), Reading Mind in the Eyes Test (RMET), and Cambridge Neuropsychological Test Automated Battery. EEG monitoring was performed for electrophsiologic investigation. In the patient group, total reading the mind scores were lower (P = .027) while P300 latencies and emotion recognition latency during the Emotion Recognition Task (ERT) were longer (P = .038 and P = .012, respectively). The false alarm scores in the Rapid Visual Information Processing Task (RVP) were higher in the patient group (P = .038). In a model created using multivariate linear regression analysis, an effect of ERT and RVP scores on LSAS scores was found. Results of our study confirm that particularly impairment of cognitive functions such as sustained attention and emotion recognition may seriously affect the clinical presentation negatively. P300 latency in the parietal region may has the potential to be a biological marker that can be used in monitoring treatment.Öğe Evaluation of the effect of shift working and sleep quality on semen parameters in men attending infertility clinic(Wiley, 2021) Demirkol, Mehmet Kutlu; Yildirim, Abdullah; Gica, Sakir; Dogan, Neslihan Temiz; Resim, SefaWe aimed to evaluate the effect of shift work on semen parameters together with the effect of sleep quality in men attending infertility clinic. The participants were divided into two groups as follows: 104 shift worker men (Group 1) and 116 nonshift worker men (Group 2). Groups were compared in terms of semen parameters, Depression Anxiety Stress Scale-21 (DASS-21), and Pittsburg Sleep Quality Index (PSQI) scores. A higher rate of oligozoospermia and poor sleep quality and a lower mean normal morphology percentage was observed in shift workers than nonshift workers (p = .006, .039 and .036 respectively). In addition, a positive correlation was seen between sleep duration and sperm concentration, while a negative correlation was found between sleep latency and total sperm count. Shift working together with high PSQI score was also a significant association with oligozoospermia when controlling for the other variables of age, total testosterone, DASS-21 stress score, smoking and varicocele (OR = 2.11, 95% CI 1.03-4.34 and OR = 1.18, 95% CI 1.01-1.39 respectively). In this study, infertile shift workers had a lower percentage of normal morphology and higher rates of oligozoospermia and poor sleep quality. Considering that shift workers have lower sleep quality, it seems that shift working negatively affects the circadian rhythm.Öğe Evening type negatively affects semen quality by deteriorating sperm morphology: Results from an infertility clinic(Elsevier, 2023) Gica, Sakir; Demirkol, Mehmet Kutlu; Yildirim, Abdullah; Dogan, Neslihan Temiz; Resim, SefaObjective: The effect of sleep-related variables on the reproductive system has garnered attention in recent years. One of the mediators that reportedly plays an important role in the relationship between sleep disorders and the reproductive system is a disruption of the circadian rhythm. The aim of curent study is to investigate the effect of chronotype on morning semen quality.Study Design: Three-hundred and fourteen patients who applied to the infertility clinic were included in the study. The patients filled a socio-demographic data form. The Pittsburg Sleep Quality Index (PSQI) was used to evaluate the sleep quality while the chronotypes of the patients were evaluated with the Morningness -Eveningness-Questionnaire (MEQ). Semen analyses and biochemical analysis for testosterone serum plasma level of all patients were performed.Results: Twenty-one patients were assigned as evening, 187 patients were assigned as intermediate, and 106 were assigned as morning chronotype. No statistically significant difference was identified in the comparison of the mean MEQ scores between patients with low and normal sperm concentrations(p = 0.884). A correlation analysis indicated the presence of a significant positive correlation between normal morphology and MEQ scores (r = 0.13, p < 0.05) and a negative corelation between the hours spent in bed and sperm concentration (r = -0.13, p < 0.05). A general linear model created with independent variables suggested that the presence of varicocele and MEQ scores had a significant effect on normal morphology.Conclusion: The results of present study support that evening type could negatively affect sperm morphology; additionally, the time spent in bed also negatively affected sperm concentration.Öğe Investigation of auditory P50 sensory gating with sexual visual stimuli in patients with vaginismus(Elsevier France-Editions Scientifiques Medicales Elsevier, 2021) Yukselay, Ozge; Gica, Sakir; Yalcin, Murat; Gulec, Medine Yazici; Gulec, HuseyinObjectives. - The aim of the study was to investigate sensory information processing induced by visual sexual stimuli and to assess its relationship with sexual behaviors and symptoms in patients with vaginismus. Methods. - Twenty-one patients with vaginismus and 20 controls were included in the study. The sociodemographic information and sexual life history of the patients with vaginismus and controls were examined and electrophysiological measurements related to auditory P50 sensory gating were obtained using a double click paradigm during by sexual/horror visual stimulation, which was thought to be related to the pathophysiology of the disease. Results. - P50 suppression ratios during visual sexual stimuli were lower in vaginismus group compared to the control group. There was no difference in P50 suppression ratios during visual horror stimuli when the two groups were compared. The P50 suppression of the vaginismus group with visual sexual stimuli was found to be lower than P50 suppression with visual horror stimuli. A positive moderate correlation was found between the duration of foreplay and P50 suppression ratio during visual sexual stimuli in vaginismus group. Conclusion. - Our study revealed that patients with vaginismus had sensory gating impairment during visual sexual stimuli. Increase in the duration of foreplay in vaginismus patients may improve sensory gating impairment by affecting sensory gating functions. (C) 2021 Elsevier Masson SAS. All rights reserved.Öğe Investigation of the effect of trazodone on spontaneous and acetylcholine-induced bladder detrusor smooth muscle contractions(Kare Publ, 2022) Burunsuz, Ozge; Ozdengul, Faik; Gica, Sakir; Sen, Aysu; Sahin, ZaferObjective: The management of psychiatric patients is often complicated by medical comorbidities, complex pharmacological regimens, and side effects secondary to these regimens. In the current study, it was aimed to investigate the effects and mechanism of action of trazodone on rat bladder smooth muscle contractility in vitro. Method: Sixteen adult male Wistar albino rats were euthanized by the cervical dislocation method following ether anesthesia. Two muscle strips of 2x10 mm in size were prepared vertically from the bladder by opening a longitudinal incision from the neck of the bladder in the direction of the apex. The strips were tied properly and hung in the organ bath. All contraction amplitudes and frequencies were recorded. After a 45-min adaptation period, contractions were induced by applying 10(-5) M acetylcholine (ACh) to all spontaneously contracting bladder strips. After 20 min, doses of trazodone (10(-9) M vs 10(-3) M) were given cumulatively. The resulting effects were recorded. Results: The groups were compared within themselves: a significant difference was found between the initial tensions in the group with ACh-induced contractions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-7), 10(-6) , 10(-5), 10(-4), and 10(-3) M doses (p<0.0001). In the group with spontaneous contractions, a significant difference was found between the initial tensions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-5), and 10(-4) M doses (p<0.0001). Conclusion: Results showed that trazodone had a significant inhibitory effect on bladder smooth muscle contractions in vitro, especially at concentrations of 10(-4) and 10(-3) M.Öğe Investigation of the effect of trazodone on spontaneous and acetylcholine-induced bladder detrusor smooth muscle contractions(Kare Publ, 2022) Burunsuz, Ozge; Ozdengul, Faik; Gica, Sakir; Sen, Aysu; Sahin, ZaferObjective: The management of psychiatric patients is often complicated by medical comorbidities, complex pharmacological regimens, and side effects secondary to these regimens. In the current study, it was aimed to investigate the effects and mechanism of action of trazodone on rat bladder smooth muscle contractility in vitro. Method: Sixteen adult male Wistar albino rats were euthanized by the cervical dislocation method following ether anesthesia. Two muscle strips of 2x10 mm in size were prepared vertically from the bladder by opening a longitudinal incision from the neck of the bladder in the direction of the apex. The strips were tied properly and hung in the organ bath. All contraction amplitudes and frequencies were recorded. After a 45-min adaptation period, contractions were induced by applying 10(-5) M acetylcholine (ACh) to all spontaneously contracting bladder strips. After 20 min, doses of trazodone (10(-9) M vs 10(-3) M) were given cumulatively. The resulting effects were recorded. Results: The groups were compared within themselves: a significant difference was found between the initial tensions in the group with ACh-induced contractions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-7), 10(-6) , 10(-5), 10(-4), and 10(-3) M doses (p<0.0001). In the group with spontaneous contractions, a significant difference was found between the initial tensions and the tensions after the administration of trazodone at 10(-9), 10(-8), 10(-5), and 10(-4) M doses (p<0.0001). Conclusion: Results showed that trazodone had a significant inhibitory effect on bladder smooth muscle contractions in vitro, especially at concentrations of 10(-4) and 10(-3) M.
