Yazar "Gokbel, Hakki" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Effects of grape seed extract on oxidative stress and antioxidant defense markers in streptozotocin-induced diabetic rats
    (Tubitak Scientific & Technological Research Council Turkey, 2015) Belviranli, Muaz; Gokbel, Hakki; Okudan, Nilsel; Buyukbas, Sadik
    Background/aim: To evaluate the effects of grape seed extract (GSE) supplementation on oxidative stress and antioxidant markers in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Thirty-six male rats were divided into the following four groups: control, GSE-supplemented control, diabetic, and GSE-supplemented diabetic. Beginning on day 7 after STZ injection, the rats were administered GSE (100 mg kg(-1) day(-1)) in drinking water for 6 weeks. At the end of week 6, rats were sacrificed by cardiac puncture. Plasma nitric oxide (NO) levels and xanthine oxidase (XO), adenosine deaminase (ADA), and glutathione peroxidase (GPx) activities were analyzed. Results: Both XO and ADA activities increased and NO levels decreased in diabetic rats (P < 0.05). GSE supplementation normalized all of these changes. Antioxidant enzyme activities decreased in diabetic rats compared to the controls (P < 0.05). GSE supplementation increased antioxidant enzyme activities in both diabetic and healthy rats (P < 0.05). Conclusion: These findings suggest that 6 weeks of oral GSE supplementation may prevent oxidative stress and improve antioxidant status in diabetic rats.
  • Küçük Resim Yok
    Öğe
    The effects of omega-3 fatty acids on exercise induced bronchospasm in nonasthmatic obese and non-obese children
    (Wiley-Blackwell, 2015) Ozdemir, Ayse; Okudan, Nilsel; Yuca, Sevil Ari; Belviranli, Muaz; Gokbel, Hakki
    [Abstract Not Availabe]