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Öğe Assessing volumetric changes in abdominal aortic aneurysms following endovascular repair(Clinics Cardive Publ Pty Ltd, 2021) Gunerhan, Yalcin; Isik, Mehmet; Dereli, Yuksel; Tanyeli, Omer; Kadiyoran, Cengiz; Iyisoy, Mehmet Sinan; Gormus, NiyaziObjective: Volumetric changes in the aneurysm sac were evaluated following endovascular aortic repair (EVAR) in intact abdominal aortic aneurysm (AAA) patients who underwent EVAR. Methods: Fifty-two patients, who underwent EVAR from 2015 to 2019, were analysed retrospectively. A total of 158 computed tomography angiography scans was examined by performing reconsctructive volumetric calculations. Total aneurysm volume (TAV), patent lumen volume (PLV) and thrombus-coated aneurysm wall volume (TCAWV) were calculated. The results obtained at six, 12 and 24 months postoperatively were compared with those of the pre-operative period. Results: Mean TAV had regressed 7% by the sixth month (p = 0.1), 27% by the 12th month (p = 0.0003) and 19% by the 24th month (p = 0.0008). Mean TCAWV had increased 2% by the sixth month (p = 0.3), and regressed 26% by the 12th month (p = 0.3) and 14% by the 24th month (p = 0.8). Mean PLV had regressed by 20% by the sixth month (p = 0.008), 29% by the 12th month (p = 0.0002) and 26% by the 24th month (p = 0.0006). For each individual proximal, middle and distal measurement, regression was observed at six and 12 months; however, an increase was observed at 24 months compared to the previous follow ups. Conclusion: The expansion measurements of TAV in the 24th month support the doubts on the medium- to long-term results of EVAR. The largest regression in the aneurysm sac was observed in the distal portion, then in the proximal portion, and the least regression was observed in the middle section.Öğe A case of May-Thurner syndrome with inconsistent radiological and surgical findings(Clinics Cardive Publ Pty Ltd, 2015) Akin, Fatih; Aygun, Serhat; Gormus, Niyazi; Kar, Yeter Duzenli; Susam, Hanife Tugce; Ozel, AhmetMay-Thurner syndrome is the result of compression of the left common iliac vein between the right common iliac artery and the overlying vertebrae. In this case report, we describe an 11-year-old boy presenting with swelling of the left lower extremity. An iliac MR venography showed compression of the left proximal iliac vein between the vertebra and the left iliac artery. In surgery, it was seen that the left common iliac vein was connected to the postero-inferior part of the inferior vena cava, and it was compressed between the right common iliac artery and the columna vertebralis, which was inconsistent with the radiological findings. An interposition of the great saphenous vein graft between the left common iliac vein and the inferior vena cava was made, with a successful outcome. Our case is interesting in that it showed inconsistent findings between the radiological images and surgery.Öğe Comparison of Fluoxetine and Sertraline in Treatment of Postoperative Depression(Wiley, 2018) Gormus, Z. Isik Solak; Gormus, Niyazi; Solak, Hatice; Koca, Raviye Ozen; Koc, Aynur; Taki, Fatma Nur; Kutlu, Selim[Abstract Not Availabe]Öğe Detection of Position of Replaced Mechanical Heart Valve with ANN(IEEE, 2013) Altunkaya, Sabri; Kara, K.; Gormus, Niyazimechanical heart valve is a device substituted for native heart valve. These valves are generally replaced with mitral or aorta valves. To found whether aorta or mitral heart valve replaced with mechanical one of patients is easy for specialist using stethoscope or chest X-ray. Expert system evaluating mechanical heart valve disease cannot deduce position of replaced heart valve. Thus, we aimed to determine which heart valve of patients was replaced with mechanical one to use preprocessing step in expert systems finding malfunctioning mechanical valve in this study. Electrocardiogram signal and 6 features extracted from power density of heart sounds were used to determine replaced heart valve using artificial neural networks. The heart sounds were separated into four parts according to recording area and sound component. Then, artificial neural networks was separately trained and tested for four sounds using the 6 features. As a result, the mechanical heart valve of patients was detected with 96.55% accuracy from the features of second heart sounds recorded from mitral area.Öğe Does Fluoksetine Reduce Positive Inotropic Effect of Heart?(Wiley, 2018) Gormus, Z. Isik Solak; Koca, Raviye Ozen; Solak, Hatice; Kutlu, Selim; Gormus, Niyazi[Abstract Not Availabe]Öğe The Effect of Phenoxybenzamine to Decreased Heart Muscle Contractility After in vitro Constituted Ischemia(Wiley-Blackwell, 2016) Gormus, Z. Isik Solak; Solak, Hatice; Koca, Raviye Ozen; Sahin, Zafer; Kutlu, Selim; Gormus, Niyazi[Abstract Not Availabe]Öğe Effects of Combined Sertraline and Magnesium in Rat Atrium(Springernature, 2022) Fidan, Esra; Gormus, Z. Isik Solak; Kilinc, Ibrahim; Iyisoy, Mehmet Sinan; Gormus, NiyaziThe objective of this study is to determine the synergistic effects of an antioxidant ion Mg+2, combined with selective serotonin reuptake inhibitor sertraline, in treatment or prevention of major depression and regulation of inotropic effect in the early postoperative period. Adult male 40 Wistar albino rats were randomly divided into 6 groups. Three to 4-mm long atrium strips were placed in organ bath, tension was adjusted to 2 g. Isometric contractions were induced with 10(-3) M adrenaline. Group 1 was the control group, cumulative sertraline was given to group 2, cumulative MgSO4 to group 3, combined cumulative sertraline and MgSO4 to group 4, intraperitoneal sertraline injection for 29 days to group 5, and intraperitoneal MgSO4 injection for 14 days to group 6. Changes in weight, tensions, bleeding/clotting time, and biochemical findings were evaluated statistically. Isometric tension relationship between groups 1 and 3 was statistically significant after 4 mmol/L MgSO4 (p < 0.05). A rapid inhibition of contraction was observed in group 4. Inhibition of spontaneous contractions of groups 5 and 6 was found to be statistically significant at close values, p < 0.05. When blood clotting times were compared, a statistically marked decrease was found in group 6, p < 0.05. Compared to control group, there was a significant decrease in blood lipids in group 4. While LDH and CK-MB increased from plasma enzymes in groups 5 and 6, no significant change was observed in NT-proBNP. Combined treatment of high dose MgSO4 with antidepressants for pre or post-operative depression may cause fatal risks. Shortening clotting time may increase the risk of embolism and stroke. In order to reduce the risk of post-operative depression preoperatively, care should be taken when using magnesium combined with antidepressants and more studies are needed to be considered.Öğe Effects of Phenoxybenzamine after Hypothermic and Normothermic Ischemia Injury in Rat Aorta(Wiley-Blackwell, 2016) Gormus, Isik Solak; Koca, Raviye Ozen; Solak, Hatice; Sahin, Zafer; Karaibrahimoglu, Adnan; Gormus, Niyazi; Kutlu, Selim[Abstract Not Availabe]Öğe Endovascular Stent-graft Placement for the Emergency Treatment of Ruptured Descending Aortic Aneurysm(Aves, 2014) Koc, Osman; Batur, Abdussamet; Karabekmez, Leman Gunbey; Gormus, Niyazi; Cil, Barbaros; Vural, AlaattinRuptured aortic aneurysm is a condition that requires emergency treatment because of its high mortality rate. In this case, we presented the emergency endovascular treatment of a ruptured descending thoracic aortic aneurysm. A female patient, admitted to the emergency with sudden onset back pain, was treated by emergency endovascular stent-graft after CT angiography examination. According to endovascular treatment, surgical treatment has a high mortality and morbidity rate in the treatment of the ruptured descending thoracic aortic aneurysms. The endovascular stent-graft treatment is applied safely and successfully to the intervention of this pathology.Öğe Evaluation of post-operative flow and diameter changes in brachial and ulnar arteries in coronary artery bypass surgery patients in which the radial artery is used as graft(Turkish Soc Cardiology, 2015) Isik, Mehmet; Yuksek, Tahir; Dereli, Yuksel; Gormus, Niyazi; Durgut, Kadir; Koc, OsmanObjective: The radial artery is widely used in coronary bypass surgery. In these patients, forearm and hand circulation is provided by the ulnar artery. This study aimed to investigate post-operative changes in flow and diameter in brachial and ulnar arteries in patients undergoing coronary bypass surgery in which the radial artery is used as graft. Methods: Between September 2007 and September 2008, 20 patients (16 men, 4 women; mean age 57.8 years; range 44 to 70 years) underwent elective coronary bypass surgery at our clinic. The radial artery was used as graft in all cases. Pre-operatively, adequacy of the ulnar artery for forearm circulation was investigated by Allen test and duplex ultrasonography. Basal flow and diameter values of the brachial and ulnar arteries were measured. Control duplex ultrasound measurements were performed at three months post-operatively. Flow and diameter changes in the brachial and ulnar arteries were recorded. Results: Significant increase was shown in ulnar artery flow and diameter values in post-operative measurements. A significant increase was observed in brachial artery diameter, accompanied by a relative decrease in flow value. There were no mortality or ischemic complications in our study. Transient paresthesia as a neurological complication was observed in 4 patients. Conclusion: Radial artery use for coronary bypass surgery leads to significant changes in ulnar and brachial arteries. All flow and diameter changes can be detected by color Doppler ultrasonography in the early stages. These adaptation mechanisms show that the radial artery can be safely harvested as graft material.Öğe Full metal jacket: transfemoral aortic valve implantation for regurgitant valve after endovascular aortic repair(Oxford Univ Press, 2017) Tanyeli, Omer; Dereli, Yuksel; Gormus, Niyazi; Duzenli, Mehmet AkifTransfemoral aortic valve implantation has become an almost routine interventional procedure for severe aortic stenosis in high-risk patients. Over time an increased number of experiences has led to unusual procedures. In this report, we present a successful valve-in-valve transfemoral aortic valve implantation in a patient with aortic regurgitation, who previously had debranching and thoracic endovascular aortic repair operations.Öğe Giant left atrial capillary haemangioma invading left-main coronary artery(Oxford Univ Press, 2021) Yildirim, Serkan; Isik, Mehmet; Tanyeli, Omer; Gormus, NiyaziCardiac haemangiomas are rare cases and can be seen at any age of life. A 49-year-old woman was admitted to our hospital with chest pain. A well-circumscribed soft tissue mass extending from the pulmonary artery truncus to the left ventricular inferior neighborhood. Following surgical resection, the patient was discharged 4 days after surgery.Öğe Is Computed Tomography the Gold Standard in Aortic Dissection?(Emergency Medicine Physicians Assoc Turkey, 2020) Tatar, Sefa; Icli, Abdullah; Akilli, Hakan; Gormus, Niyazi; Sertdemir, Ahmet LutfuIntroduction: Aortic dissection is a disease with high mortality, which is characterized by a tear in the aortic wall. Thanks to early diagnosis and treatment, patients' survival rates are high. Chest pain is the most common symptom. Imaging methods help in diagnosis. Its treatment is surgery. Case Report: A 47-year-old male patient was admitted to the emergency department with chest pain. The diagnosis of aortic dissection in computed tomography was evaluated as motion artifact and valve motion, and he was asked to be discharged from the emergency service after his diagnosis was missed. However, transesophageal echocardiography was performed because of the patient's clinical symptom and echocardiographic findings supported the aortic dissection. When a dissection flap was seen in transesophageal echocardiography, the patient was transferred to surgery. In surgery, a dacron graft was placed in the patient's aorta and a prosthetic valve was placed on the aortic valve, and left main coronary repair and right coronary is bypass were performed. The patient was discharged without any problem. Conclusion: Aortic dissection is a clinical diagnosis, it is a disease with high mortality. Imaging methods are helpful in diagnosis, but the fact that imaging methods rule out dissection does not always rule out the disease. The important thing is to suspect the disease and to consider the patient's current clinical symptoms and signs.Öğe Management of Cardiac Surgery in a Pandemic Region Hospital: Precautions, Results and Experiences During COVID-19(Aves, 2021) Isik, Mehmet; Yildirim, Serkan; Dereli, Yuksel; Tanyeli, Omer; Gormus, NiyaziObjective: The aim of the present study was to share the experiences gained from emergency and semi-emergency cases of open heart surgery performed during the COVID-19 outbreak in Necmettin. Erbakan University Meram Medical Faculty Hospital, which was defined as a pandemic hospital by Turkish Ministry of Health and provided third degree health services. Materials and Methods: A total of 54 patients were retrospectively analyzed between 23 March and 22 May 2020, who were diagnosed to have aortic dissection, coronary artery disease, and heart valve diseases. Results: Thirty-two CABG, 12 valve surgery, 6 aortic surgery, 4 CABG + valve surgeries were performed. During the postoperative follow-up of I I patients, who were suspicious of COVID-19, 8 of them displayed respiratory problems and partial oxygen depletion and required continuous positive airway pressure. The hospitalization duration of COVID-19-suspicious patients were approximately 5 days longer than that of normal patients. In one of the patient, who was treated positive for COVID-19, acute coronary syndrome developed and CABG was performed following the treatment. Conclusion: During the pandemic period, acute cardiac diseases needing urgent surgery could be misdiagnosed because of similar symptoms with COVID-19 and the health care practitioners concentrated with the COVID-19 primarily. On the other hand, pandemic fear could cause delayed admission to the hospital and increased postoperative mortality and morbidity. When a COVID-19 positive or -suspicious patient undergo open-heart surgery, problems resulting from both COVID-19 infection and cardiopulmonary bypass-associated systemic effects could arise. The combination of these two cases could worsen the complications.Öğe New World's old disease: cardiac hydatid disease and surgical principles(Clinics Cardive Publ Pty Ltd, 2017) Tanyeli, Omer; Dereli, Yuksel; Mercan, Ilker; Gormus, Niyazi; Yuksek, TahirBackground: Hydatid cyst is a parasitic disease caused by infection with the Echinococcus granulosus tapeworm larva. It is a major public health problem in endemic regions. Cardiac involvement of the disease is rare. Methods: Between 1985 and 2015, 12 patients were admitted to our clinic with a possible diagnosis of cardiac hydatid disease. Of these patients, six (50%) were male and six (50%) were female. Mean age of the patients was 42.6 years. Results: The most common location of cardiac hydatid disease was left sided (six patients, 50%). Five (41.7%) patients had cysts located in the right heart, whereas one (8.3%) had a cyst in the interventricular septum. Eleven (91.7%) of the patients were operated on via median sternotomy and the remaining one was operated on via a left anterolateral thoracotomy. Ten (83.3%) of the patients were operated on using cardiopulmonary bypass under moderate hypothermia, whereas the remaining two (16.7%) had off-pump surgery. There was no surgical mortality in our series. All patients were discharged with medical therapy (mebendazole or albendazole) for the duration of six months. No recurrences were observed in their follow ups. Conclusion: Although cardiac hydatid disease is rare, its prevalence seems to have increased in the last decade. Any patient with suspected cardiac symptoms suggesting mass lesions should be considered for a differential diagnosis of cardiac hydatid disease, especially in developing countries. Definitive treatment is removal of the cyst, combined with medical therapy.Öğe Predictive Value of Neutrophil-to-Lymphocyte, Aspartate-to-Alanine Aminotransferase, Lymphocyte-to-Monocyte and Platelet-to-Lymphocyte Ratios in Severity and Side of Carotid Artery Stenosis: Are Those Significant?(Forum Multimedia Publishing, Llc, 2021) Altinbas, Ozgur; Demiryurek, Seniz; Isik, Mehmet; Tanyeli, Omer; Dereli, Yuksel; Gormus, NiyaziBackground: Atherosclerosis is a chronic disease that leads to mortality and morbidity by affecting arterial vascular structures. Carotid artery is one of these arterial structures and occlusive disease of carotid artery may cause stroke or cranial ischemic infarction. Inflammation plays a role in the atherosclerotic process. In this study, we aimed to discuss the relationship between the severity and side of carotid artery occlusion and novel inflammatory parameters include platelet-to-lymphocyte, neutrophil-to-lymphocyte, lymphocyte-to-monocyte, and aspartate-to-alanine aminotransferase ratios. Methods: One-hundred-fifteen patients who had carotid artery stenosis between 50%-99% and 115 healthy subjects with no carotid artery stenosis or additional disease were included in the study. The relationship between the side and degree of the lesion and platelet-to-lymphocyte, neutrophil-to-lymphocyte, lymphocyte-to-monocyte, and aspartate-to-alanine aminotransferase ratios were studied in the patient group. The patients with carotid artery stenosis and the healthy subjects were compared, in the terms of same parameters. Data were evaluated statistically. Results: There were no statistically significant differences between the groups, in the terms of platelet-to-lymphocyte, neutrophil-to-lymphocyte, lymphocyte-to-monocyte, and aspartate-to-alanine aminotransferase ratios and the degree of stenosis. There was no statistically significant difference between the sides of the lesions and the parameters above except lymphocyte-to-monocyte ratio. It was statistically significantly higher in left-sided lesions. Aspartate-to-alanine aminotransferase and neutrophil-to-lymphocyte ratios were markedly higher in the patient group, when compared to controls. Conclusion: Platelet-to-lymphocyte, neutrophil-tolymphocyte, lymphocyte-to-monocyte, and aspartate-to-alanine aminotransferase ratios are inexpensive, easy, fast, and reproducible parameters that can be used in determining the prediction of carotid artery stenosis.Öğe Predictive Value of Neutrophil-to-Lymphocyte, Aspartate-to-Alanine Aminotransferase, Lymphocyte-to-Monocyte and Platelet-to-Lymphocyte Ratios in Severity and Side of Carotid Artery Stenosis: Are Those Significant?(Forum Multimedia Publishing, Llc, 2021) Altinbas, Ozgur; Demiryurek, Seniz; Isik, Mehmet; Tanyeli, Omer; Dereli, Yuksel; Gormus, NiyaziBackground: Atherosclerosis is a chronic disease that leads to mortality and morbidity by affecting arterial vascular structures. Carotid artery is one of these arterial structures and occlusive disease of carotid artery may cause stroke or cranial ischemic infarction. Inflammation plays a role in the atherosclerotic process. In this study, we aimed to discuss the relationship between the severity and side of carotid artery occlusion and novel inflammatory parameters include platelet-to-lymphocyte, neutrophil-to-lymphocyte, lymphocyte-to-monocyte, and aspartate-to-alanine aminotransferase ratios. Methods: One-hundred-fifteen patients who had carotid artery stenosis between 50%-99% and 115 healthy subjects with no carotid artery stenosis or additional disease were included in the study. The relationship between the side and degree of the lesion and platelet-to-lymphocyte, neutrophil-to-lymphocyte, lymphocyte-to-monocyte, and aspartate-to-alanine aminotransferase ratios were studied in the patient group. The patients with carotid artery stenosis and the healthy subjects were compared, in the terms of same parameters. Data were evaluated statistically. Results: There were no statistically significant differences between the groups, in the terms of platelet-to-lymphocyte, neutrophil-to-lymphocyte, lymphocyte-to-monocyte, and aspartate-to-alanine aminotransferase ratios and the degree of stenosis. There was no statistically significant difference between the sides of the lesions and the parameters above except lymphocyte-to-monocyte ratio. It was statistically significantly higher in left-sided lesions. Aspartate-to-alanine aminotransferase and neutrophil-to-lymphocyte ratios were markedly higher in the patient group, when compared to controls. Conclusion: Platelet-to-lymphocyte, neutrophil-tolymphocyte, lymphocyte-to-monocyte, and aspartate-to-alanine aminotransferase ratios are inexpensive, easy, fast, and reproducible parameters that can be used in determining the prediction of carotid artery stenosis.Öğe Prevention of Retrosternal Pericardial Adhesions After Cardiac Surgery With Mitomycin C(Elsevier Science Inc, 2014) Orhan, Atilla; Gormus, Niyazi; Toy, Hatice; Gormus, Isik Solak; Caglayan, Osman; Tanyeli, OmerBackground Cross Mark Retrosternal pericardial adhesions may cause significant injuries to the heart and great vessels in cases that require reoperation. Fibroblast proliferation is one of the mechanisms for adhesion formation. Inhibition of fibroblast proliferation is important in reduction of retrosternal adhesions. Mitomycin C (MMC) is able to reduce fibroblast proliferation. We aimed to determine the effect of MMC on prevention of retrosternal pericardial adhesions after primary cardiac operations. Methods Thirty Sprague-Dawley female rats were used in the study. The rats were divided into two groups. First group was control (n = 10) and second group was MMC study group (n = 20). Xiphoid cartilage resection and retrosternal abrasion via subxiphoidal incision was performed. In the study group, MMC (1 mg/kg) was topically applied to the retrosternal space. After 15 days, rats were taken into reoperation and adhesion was graded. Tissue and blood samples were taken before termination procedure. Standard staining procedures and fibroblast growth factor receptor 3 antibody staining, were applied immunohistochemically to tissue samples. Results The average adhesion scores of the control (n = 10) and study (n = 20) (MMC; 1 mg/kg) groups were 2.50 +/- 1.27 and 0.70 +/- 0.86, respectively. The adhesion score of the study group was lower than the control group (p < 0.05). Immunohistochemical samples revealed that tissue fibroblast intensity was significantly higher in the control group than the study group (p < 0.05). There was no statistical significance between two groups in case of hydroxyproline levels (p > 0.05). Conclusion MMC was found to be effective in the prevention of retrosternal pericardial adhesions without any delay in normal tissue regeneration.Öğe Primary Intravascular Lipoma of the Superior Vena Cava(Galenos Publ House, 2015) Tanyeli, Omer; Dereli, Yuksel; Gormus, Niyazi; Odev, Kemal[Abstract Not Availabe]Öğe Rare images of tuberculous pericarditis causing constrictive pericarditis(Oxford Univ Press Inc, 2014) Tanyeli, Omer; Dereli, Yuksel; Gormus, Niyazi[Abstract Not Availabe]
