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Öğe Comparison of Fluoxetine and Sertraline in Treatment of Postoperative Depression(Wiley, 2018) Gormus, Z. Isik Solak; Gormus, Niyazi; Solak, Hatice; Koca, Raviye Ozen; Koc, Aynur; Taki, Fatma Nur; Kutlu, Selim[Abstract Not Availabe]Öğe A different marker to determine arrhythmia potential between elite active cyclists and veterans: T peak T end(Wiley-Blackwell, 2015) Gormus, Z. Isik Solak; Isik, Bulent; Ciftci, Ozgur; Icli, Abdullah; Togan, Turhan; Aslan, Huseyin; Kutlu, Selim[Abstract Not Availabe]Öğe Does Fluoksetine Reduce Positive Inotropic Effect of Heart?(Wiley, 2018) Gormus, Z. Isik Solak; Koca, Raviye Ozen; Solak, Hatice; Kutlu, Selim; Gormus, Niyazi[Abstract Not Availabe]Öğe Does Neurokinin 3 Receptor Agonism Affect Hippocampal Neurogenesis in an Experimental Rat Model of Alzheimer's Disease?(Wiley, 2023) Koca, Raviye Ozen; Gormus, Z. Isik Solak; Solak, Hatice; Celik, Fatma Secer; Kurar, Ercan; Kutlu, Selim[Abstract Not Availabe]Öğe Does Pregabalin Affect Renal Functions and Plasma Electrolytes?(Wiley, 2023) Gunay, Ahmet Can; Gormus, Z. Isik Solak; Gunay, Merve Akgul; Koca, Raviye Ozen; Ozdengul, Faik[Abstract Not Availabe]Öğe Does Sertraline Affect Hypothalamic Food Intake Peptides in the Rat Experimental Model of Chronic Mild Stress-Induced Depression?(Springer/Plenum Publishers, 2022) Solak, Hatice; Gormus, Z. Isik Solak; Koca, Raviye Ozen; Gunes, Canan Eroglu; Kutlu, SelimDepression is a chronic, recurrent and life-threatening disease affecting approximately 15% of the world population. Depression is responsible for neuropathologies like decreased neurogenesis and increased dendritic atrophy. Antidepressant treatments increase hippocampal neurogenesis and neurotrophic factor expression. Based on this information, it was aimed to investigate effect of sertraline on depression in rats with chronic mild stress (CMS) model and to determine how it affects cell proliferation and hypothalamic peptide levels in hypothalamus. 56 adult male Wistar albino; control, depression(D), depression + sertraline, sertraline were divided into groups. Various stressors were applied to D for 30 days. Open field test (OFT) and forced swimming test (FST) were conducted to check whether the animals were depressed. On the 16th day osmotic minipump was placed subcutaneously and sertraline (10 mg/kg/day) was administered for 15 days. Behavior tests were done. Hypothalamic peptide gene expression levels were analyzed by quantitative RT-PCR. Statistical evaluations were made using ANOVA. It caused a decrease in the percentage of movement in the D and control groups in the OFT, an increase in the immobility time in the D group in the FST, and an increase in the swimming behavior in the DS group. Animals did not show any anxiological behavior based on the elevated plus maze test results. CMS caused a decrease in GLUT2 and NPY gene expression in the hypothalamus of animals, an increase in POMC and FGFR2, and an increase in IGFIR and GLUT2 gene expression in the DS group. Sertraline has been shown to ameliorate the effects of CMS-induced depression. Sertraline is thought to have a positive regulatory effect on both the formation of neural precursor cells and the survival of newly formed neurons in the hypothalamus. Newly formed neurons in the hypothalamus express food intake-related NPY, POMC, GLUT2 neurons, and thus hypothalamic tanycytes may play a key role in the control of energy metabolism.Öğe Effect of Intravenous Glucose Administration on Catecholamine Concentrations in Hypothalamic Ventromedial Nucleus in Rats: A Microdialysis Study(Wiley-Blackwell, 2016) Solak, Hatice; Koca, Raviye Ozen; Gormus, Z. Isik Solak; Sahin, Zafer; Koc, Aynur; Karaibrahimoglu, Adnan; Kutlu, Selim[Abstract Not Availabe]Öğe The Effect of Phenoxybenzamine to Decreased Heart Muscle Contractility After in vitro Constituted Ischemia(Wiley-Blackwell, 2016) Gormus, Z. Isik Solak; Solak, Hatice; Koca, Raviye Ozen; Sahin, Zafer; Kutlu, Selim; Gormus, Niyazi[Abstract Not Availabe]Öğe The Effect of Sertraline on Cognitive Behaviors in Depressed Rats with Chronic Mild Stress Model(Wiley, 2022) Solak, Hatice; Gormus, Z. Isik Solak; Koca, Raviye Ozen; Kurar, Ercan; Kutlu, Selim[Abstract Not Availabe]Öğe Effects of Combined Sertraline and Magnesium in Rat Atrium(Springernature, 2022) Fidan, Esra; Gormus, Z. Isik Solak; Kilinc, Ibrahim; Iyisoy, Mehmet Sinan; Gormus, NiyaziThe objective of this study is to determine the synergistic effects of an antioxidant ion Mg+2, combined with selective serotonin reuptake inhibitor sertraline, in treatment or prevention of major depression and regulation of inotropic effect in the early postoperative period. Adult male 40 Wistar albino rats were randomly divided into 6 groups. Three to 4-mm long atrium strips were placed in organ bath, tension was adjusted to 2 g. Isometric contractions were induced with 10(-3) M adrenaline. Group 1 was the control group, cumulative sertraline was given to group 2, cumulative MgSO4 to group 3, combined cumulative sertraline and MgSO4 to group 4, intraperitoneal sertraline injection for 29 days to group 5, and intraperitoneal MgSO4 injection for 14 days to group 6. Changes in weight, tensions, bleeding/clotting time, and biochemical findings were evaluated statistically. Isometric tension relationship between groups 1 and 3 was statistically significant after 4 mmol/L MgSO4 (p < 0.05). A rapid inhibition of contraction was observed in group 4. Inhibition of spontaneous contractions of groups 5 and 6 was found to be statistically significant at close values, p < 0.05. When blood clotting times were compared, a statistically marked decrease was found in group 6, p < 0.05. Compared to control group, there was a significant decrease in blood lipids in group 4. While LDH and CK-MB increased from plasma enzymes in groups 5 and 6, no significant change was observed in NT-proBNP. Combined treatment of high dose MgSO4 with antidepressants for pre or post-operative depression may cause fatal risks. Shortening clotting time may increase the risk of embolism and stroke. In order to reduce the risk of post-operative depression preoperatively, care should be taken when using magnesium combined with antidepressants and more studies are needed to be considered.Öğe Effects of Fluoxetine in Healty and Damaged Rat Aorta(Wiley, 2018) Taki, Fatma Nur; Solak, Hatice; Koca, Raviye Ozen; Ozdengul, Faik; Gormus, Z. Isik Solak; Kutlu, Selim[Abstract Not Availabe]Öğe Effects of Sertralin on in Vitro Rat Uterus Contractions(Wiley, 2018) Ozdengul, Faik; Koca, Raviye Ozen; Taki, Fatmanur; Solak, Hatice; Gormus, Z. Isik Solak; Kutlu, Selim[Abstract Not Availabe]Öğe The evaluation of tibial torsion angle after anterior cruciate ligament reconstruction(Wiley-Blackwell, 2015) Kurklu, Galip Bilen; Gormus, Z. Isik Solak; Celebi, Mehmet Mesut; Zergeroglu, Ali Murat[Abstract Not Availabe]Öğe Investigation of Effects of Dimethyl Sulphoxide on Smooth Muscle Contractions in Rat Tissues in Isolated Organ Baths(Wiley, 2017) Solak, Hatice; Taki, Fatma Nur; Koc, Aynur; Koca, Raviye Ozen; Gormus, Z. Isik Solak; Sahin, Zafer; Kutlu, Selim[Abstract Not Availabe]Öğe Investigation of the Effect of Sertraline on Contraction Strength of the Heart; In Vitro Model(Wiley, 2019) Fidan, Esra; Gormus, Z. Isik Solak[Abstract Not Availabe]Öğe Long Period Housing in Metabolic Cage Causes Unfavorable Effects on Psychophysiological Parameters in Adult Male Rats(Wiley, 2017) Sahin, Zafer; Solak, Hatice; Koc, Aynur; Koca, Raviye Ozen; Ozkurkculer, Alparslan; Candan, Pinar; Gormus, Z. Isik Solak[Abstract Not Availabe]Öğe Neurokinin 3 Receptor Effects on Cognitive Behaviours in a Rat Model of Alzheimer's Disease(Karger, 2021) Koca, Raviye Ozen; Gormus, Z. Isik Solak; Solak, Hatice; Kutlu, Selim[Abstract Not Availabe]Öğe Selection of Housekeeping Genes for Rat Hippocampus Expression Studies: Alzheimer's Disease Model(Karger, 2021) Celik, Fatma Secer; Koca, Raviye Ozen; Solak, Hatice; Gormus, Z. Isik Solak; Kutlu, Selim; Kurar, Ercan[Abstract Not Availabe]Öğe Which Antidepressant is Safer for a Postoperative Cardiac Patient?(Wiley, 2018) Gormus, Niyazi; Gormus, Z. Isik Solak; Koc, Aynur; Solak, Hatice; Koca, Raviye Ozen; Taki, Fatma Nur; Ozdemir, Ayse[Abstract Not Availabe]Öğe Which one is Safer? Agomelatine or Fluoxetine?(Wiley, 2018) Koca, Raviye Ozen; Gormus, Z. Isik Solak; Solak, Hatice; Ozdemir, Ayse; Kutlu, Selim; Gormus, Niyazi[Abstract Not Availabe]
