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Öğe Determination of Cardiac Physiological Changes in Experimental Morphine Addiction Model with Rats(Wiley, 2022) Cagliyan, Hande; Gormus, Zulfikare Isik Solak; Solak, Hatice; Koca, Raviye Ozen[Abstract Not Availabe]Öğe Does Phosphodiesterase Inhibiting Agent-Milrinone Prevent Negative Inotropic Effects of Sertraline on Postoperative Human Heart Muscle Contractility? An In Vitro Experimental Study(Wiley, 2017) Gormus, Zulfikare Isik Solak; Koca, Raviye Ozen; Koc, Aynur; Solak, Hatice; Ozdemir, Ayse; Sahin, Zafer; Kutlu, Selim[Abstract Not Availabe]Öğe The Effects of Agomelatine, Fluoxetine and Sertraline on Overactive Bladder(Wiley, 2019) Vidin, Tuba; Gormus, Zulfikare Isik Solak[Abstract Not Availabe]Öğe The effects of agomelatine, fluoxetine, and sertraline on rat bladder contraction in vitro(Kare Publ, 2023) Gormus, Zulfikare Isik Solak; Vidin, Tuba; Koca, Raviye Ozen; Solak, Hatice; Uslu, Esra FidanObjective: This study aimed to determine the potential effects of three popular antidepressants: agomelatine, fluoxetine, and sertraline on in vitro rat bladder contraction responses, and to investigate their contribution to overactive bladder syndrome. Method: Thirty-two adult male Wistar albino rats, weighing between 300-350 g, were randomly divided into four groups (Control, Agomelatine, Fluoxetine, Sertraline). After cervical dislocation, the bladders were promptly removed, cut into 3-4-millimeter strips, and suspended in an isolated organ bath at a tension of 1 gram. Contractions were induced by acetylcholine (ACh) at a concentration of 10(-5) M. Cumulative doses of agomelatine, fluoxetine, and sertraline (ranging from 10(-8) to 10(-3) M) were administered to the organ bath chambers. The least squares means were compared using the Tukey-Kramer post-hoc test to compare the tension values of the groups at different time points.Results: The inhibition of rat bladder contractions was statistically significant at agomelatine doses of 10(-7) M (p=0.0413), 10(-6) M (p=0.033), 10(-5)M (p=0.003), and 10(-4) M (p<0.001), with a statistically significant recontraction response noticed after the agomelatine dose of 10(-3) M (p<0.001). Cumulative fluoxetine doses at 10(-7) M (p=0.0182), 10(-6) M (p=0.0012), and 10(-5), 10(-4), 10(-3) M (all at p<0.001), along with sertraline doses at 10(-5) M (p=0.0096), 10(-4) M (p=0.001), and 10(-3) M (p<0.001), also significantly inhibited contraction. Conclusion: Agomelatine, fluoxetine, and sertraline were found to exhibit inhibitory effects on bladder contraction in a dose-dependent manner.Öğe The effects of agomelatine, fluoxetine, and sertraline on rat bladder contraction in vitro(Kare Publ, 2023) Gormus, Zulfikare Isik Solak; Vidin, Tuba; Koca, Raviye Ozen; Solak, Hatice; Uslu, Esra FidanObjective: This study aimed to determine the potential effects of three popular antidepressants: agomelatine, fluoxetine, and sertraline on in vitro rat bladder contraction responses, and to investigate their contribution to overactive bladder syndrome. Method: Thirty-two adult male Wistar albino rats, weighing between 300-350 g, were randomly divided into four groups (Control, Agomelatine, Fluoxetine, Sertraline). After cervical dislocation, the bladders were promptly removed, cut into 3-4-millimeter strips, and suspended in an isolated organ bath at a tension of 1 gram. Contractions were induced by acetylcholine (ACh) at a concentration of 10(-5) M. Cumulative doses of agomelatine, fluoxetine, and sertraline (ranging from 10(-8) to 10(-3) M) were administered to the organ bath chambers. The least squares means were compared using the Tukey-Kramer post-hoc test to compare the tension values of the groups at different time points.Results: The inhibition of rat bladder contractions was statistically significant at agomelatine doses of 10(-7) M (p=0.0413), 10(-6) M (p=0.033), 10(-5)M (p=0.003), and 10(-4) M (p<0.001), with a statistically significant recontraction response noticed after the agomelatine dose of 10(-3) M (p<0.001). Cumulative fluoxetine doses at 10(-7) M (p=0.0182), 10(-6) M (p=0.0012), and 10(-5), 10(-4), 10(-3) M (all at p<0.001), along with sertraline doses at 10(-5) M (p=0.0096), 10(-4) M (p=0.001), and 10(-3) M (p<0.001), also significantly inhibited contraction. Conclusion: Agomelatine, fluoxetine, and sertraline were found to exhibit inhibitory effects on bladder contraction in a dose-dependent manner.Öğe Effects of Resveratrol on In Vitro Stomach Smooth Muscle Contraction in Rats with Hepatocellular Carcinoma(Wiley, 2017) Koc, Aynur; Cetinkaya, Seda; Solak, Hatice; Gormus, Zulfikare Isik Solak; Kutlu, Selim; Ozgorgulu, Aydan[Abstract Not Availabe]Öğe Evaluation of Effects of Three Distinct Stress Protocols on Depression and/or Anxiety-like Behaviors in Female Rats(Wiley, 2017) Sahin, Zafer; Koc, Aynur; Koca, Raviye Ozen; Solak, Hatice; Ozkurkculer, Alpaslan; Gormus, Zulfikare Isik Solak; Kutlu, Selim[Abstract Not Availabe]Öğe Investigation of Effect of Intravenous Glucose Administration on Noradrenaline Levels in Lateral Hypothalamic Area by using Microdialysis Method in Rat(Wiley-Blackwell, 2015) Solak, Hatice; Koca, Raviye Ozen; Gormus, Zulfikare Isik Solak; Sahin, Zafer; Koc, Aynur; Kutlu, Selim[Abstract Not Availabe]Öğe Long-term metabolic cage housing increases anxiety/depression-related behaviours in adult male rats(Taylor & Francis Ltd, 2019) Sahin, Zafer; Solak, Hatice; Koc, Aynur; Koca, Raviye Ozen; Ozkurkculer, Alpaslan; Cakan, Pinar; Gormus, Zulfikare Isik SolakThere are several reports on unfavourable effects of metabolic cage housing on animal welfare mainly due to the characteristic structures of these cages such as single housing and grid flooring. This study was aimed to compare the effects of long-term metabolic cage housing and conventional housing (normal grouped housing in standard cages) on the anxiety/depression-like behaviours in male rats. Anxiety/depression-related behaviours were evaluated by use of forced swimming test and open field test. Swimming and climbing were significantly lower and immobility duration higher in the metabolic cage group. In the open field test, total distance, mean velocity, time spent in the central area, zone transition, grooming, and rearing scores were significantly lower in the metabolic cage. Moreover, serum corticosterone level was higher in the metabolic cage group. The results of the study indicate that long-term metabolic cage housing may cause an increase in the anxiety- and depression-related behaviours in male rats.Öğe Nesfatin-1 may Interfere with Kisspeptin/kiss1 Systemin Gonadal Activity of Female Rats(Wiley, 2016) Sahin, Zafer; Cuce, Gkhan; Ozcan, Mete; Canpolat, Sinan; Gormus, Zulfikare Isik Solak; Kutlu, Selim; Kelestimur, Haluk[Abstract Not Availabe]
