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Öğe Antidepressant-Induced Sleep Bruxism: Prevalence, Incidence, and Related Factors(Lippincott Williams & Wilkins, 2015) Uca, Ali Ulvi; Uguz, Faruk; Kozak, Hasan Huseyin; Gumus, Haluk; Aksoy, Fadime; Seyithanoglu, Abdullah; Kurt, Hatice GuncuObjective The relationship between sleep bruxism and antidepressant drugs in patients remains unclear. In this study, we aimed to investigate the incidence rate of antidepressant-related bruxism and to examine whether antidepressant use is associated with this adverse effect in the patients. Methods The study sample was gathered from 2 hospitals. A total of 807 patients who met the inclusion criteria were included in the study. The sample was divided into 2 groups: the antidepressant group (n = 506) and the control group (n = 301). Sleep bruxism was established with reports from the study participants on the basis of the International Classification of Sleep Disorders: Diagnosis and Coding Manual Second Edition. Results The prevalence of bruxism was significantly higher in the antidepressant group (24.3%) than in the control group (15.3%). The incidence of antidepressant-induced bruxism was 14.0%. The antidepressants most associated with bruxism were paroxetine, venlafaxine, and duloxetine. The patients experiencing antidepressant-induced bruxism had higher age compared with those who did not experience this adverse effect. Conclusions The results of the present study suggest that bruxism is frequently observed in women taking antidepressants and that it seems to be associated with antidepressant use at least in some patients.Öğe Assessment of Early Stage Non-Motor Symptoms in Parkinson's Disease(Turkish Neurological Soc, 2013) Gumus, Haluk; Akpinar, Zehra; Demir, OrhanObjective: In this study, our purpose is to asses the frequency of non-motor symptoms and to discuss its effect on the morbidity of the disease. Material and Met-hod: We included 80 Parkinson's patients diagnosed according to the United Kingdom Brain Bank Criteria with a clinical stage of Hoehn Yahr stages 1 and 2, who were followed in the Department of Neurology. Results: We have seen an increase in the frequency of non-motor symptoms in patients with higher UPDRS scores. Discussion: Non-motor symptoms in Parkinson's disease can often go unnoticed. The success of the treatment also depend on the symptomatic treatment. Therefore, non-motor symptoms should be detected and treated early during the course of the disease.Öğe Concomitant neuromyelitis optica and cytomegalovirus-associated retinitis in an immunocompetent female(Springer Heidelberg, 2014) Tokgoz, Serhat; Dogan, Ebru Apaydin; Gumus, Haluk; Ilhan, Nurhan; Ural, Onur[Abstract Not Availabe]Öğe Effects of Multiple Sclerosis on Female Sexuality: A Controlled Study(Elsevier Sci Ltd, 2014) Gumus, Haluk; Akpinar, Zehra; Yilmaz, HalimAim. The aim of this study was to investigate the effects of multiple sclerosis (MS) on female sexuality. Methods. Present study included 142 females (70 MS patients, 72 healthy controls). MS patients were evaluated by Expanded Disability Status Scale (EDSS) for functional status, by Beck Depression Inventory (BDI) for severity of depression, by Visual Analog Scale (VAS) for severity of pain, and by Female Sexual Function Inventory (FSFI) for sexual function. Main Outcome Measures. FSFI, BDI, EDSS, and VAS were the main outcome measures. Results. The number of weekly sexual intercourse, total FSFI, and FSFI subscale scores were lower in MS women compared with controls. FSFI total and FSFI subscale scores were statistically significantly lower in MS women with BDI score >= 17 compared with those with BDI score <17. A negative correlation was found between total FSFI score and BDI, EDSS, VAS, age, and duration of complaint, but a positive correlation was found with education level in MS women. Conclusions. Sexual functions are negatively affected in MS women. Sexual functions in MS women seem to be associated with enhanced disability, pain, duration of the disease, and degree of concomitant depression. Therefore, women with MS should also be evaluated in terms of sexual function during routine follow-ups.Öğe Parkinsonism Related to Varenicline in a Patient During Smoking Cessation(Lippincott Williams & Wilkins, 2015) Uca, Ali Ulvi; Kozak, Hasan Huseyin; Uguz, Faruk; Gumus, Haluk[Abstract Not Availabe]Öğe Postanoxic Parkinsonism: A Case Report(Turkish Neurological Soc, 2013) Gumus, Haluk; Guney, FigenPostanoxic encephalopathy is a rare syndrome manifested by neurological signs in the late period. In this case we aim to discuss postanoxic parkinsonism occurring late following resuscitation.Öğe The Relationship Between Pain and Clinical Features in Multiple Sclerosis(Turkish Neurological Soc, 2014) Akpinar, Zehra; Tokgoz, Osman Serhat; Gumus, HalukObjective: Multiple sclerosis (MS) is an autoimmune-neurodegenerative disease of the central nervous system. The prevalence of pain is between 29% and 86% and besides neuropathic pain, somatic pain types may also emerge together or separately. In this study we aimed to analyze the relationship between pain and other clinical features in MS. Materials and Methods: One-hundred cases who were followed in MS clinic and who have complaints of pain, were included in this study. We evaluated pain type and localization during patients were filling in the forms. We applied Visual Pain Scale (VPS), Ashworth Spasticity Scale (ASS) and Beck Depression Scale (BDS). Results: When female and male patients were compared, there were no statistical differences between age, disease duration and EDDS scores. Seventy seven percent of cases complained of neuropathic pain, 21% of cases had Lhermitte symptoms. Trigeminal neuralgia has been observed in 1% of cases and 55% of neuropathic extremity pain. In 60% of the cases nociceptive pains, in 12% of the cases joint-extremity-muscle pain, in 47% headache and in 1% painful tonic spasms were present. Pain depending on the treatment was observed only in 2% of the cases. The pain score was high in patients with spasticity and depression. Although there was reasonable positive correlation between age, EDDS score and VPS, poor correlation was obtained between disease period and number of attacks. Conclusion: These findings indicate that MS pain is related with spasticity, disability and depression and these clinical findings should be taken into account during pain treatment.Öğe The Role of Zinc Status on Spatial Memory, Hippocampal Synaptic Plasticity, and Insulin Signaling in icv-STZ-Induced Sporadic Alzheimer's-Like Disease in Rats(Springernature, 2022) Baltaci, Saltuk Bugra; Unal, Omer; Gulbahce-Mutlu, Elif; Gumus, Haluk; Pehlivanoglu, Suray; Yardimci, Ahmet; Mogulkoc, RasimAlzheimer's disease (AD), especially its sporadic form (sAD), is of multifactorial nature. Brain insulin resistance and disrupted zinc homeostasis are two key aspects of AD that remain to be elucidated. Here, we investigated the effects of dietary zinc deficiency and supplementation on memory, hippocampal synaptic plasticity, and insulin signaling in intracerebroventricular streptozotocin (icv-STZ)-induced sAD in rats. The memory performance was evaluated by Morris water maze. The expression of hippocampal protein and mRNA levels of targets related to synaptic plasticity and insulin pathway was assessed by Western blot and real-time quantitative PCR. We found memory deficits in icv-STZ rats, which were fully recovered by zinc supplementation. Western blot analysis revealed that icv-STZ treatment significantly reduced hippocampal PSD95 and p-GSK3 beta, and zinc supplementation restored the normal protein levels. mRNA levels of BDNF, PSD95, SIRT1, GLUT4, insulin receptor, and ZnT3 were found to be reduced by icv-STZ and reestablished by zinc supplementation. Our data suggest that zinc supplementation improves cognitive deficits and rescues the decline in key molecular targets of synaptic plasticity and insulin signaling in hippocampus caused by icv-STZ induced sAD in rats.Öğe Sjogren Syndrome Simulating Relapsing Remitting Multiple Sclerosis Clinical Features: Case Report(Turkish Neurological Soc, 2013) Gumus, Haluk; Akpinar, ZehraSjogren syndrome (SS) is a chronic, inflammatory, autoimmune disease. It primarily presents with dry mouth and eyes (sicca symptoms) because it frequently affects exocrine, salivary and lacrimal glands. Neurological involvement in Sjogren syndrome is observed in approximately 20-25% of cases. Eighty seven percent of the neurological involvements are located in the peripheral nervous system and around 13% of the neurological involvements affect the central nervous system. Cerebral involvement presents a heterogeneous profile both in terms of localization (focal or diffuse) and progress of the condition (acute, progressive or reversible). The affected central nervous system can show clinical and radiological signs similar to multiple sclerosis (MS). A case with reported imbalance and difficulty in walking, who also showed MS-like lesions in magnetic resonance imaging and was previously diagnosed with Sjogren syndrome, is discussed.
