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    The Effect of Enteral Nutrition Support Rich in TGF-? in the Treatment of Inflammatory Bowel Disease in Childhood
    (Mdpi, 2019) Agin, Mehmet; Yucel, Aylin; Gumus, Meltem; Yuksekkaya, Hasan Ali; Tumgor, Gokhan
    Background and Objective: Malnutrition is a major complication of inflammatory bowel disease (IBD). Our aim of the study was to examine the effects of Modulen IBD supplementation, which was administered to IBD patients without limiting their daily diet in addition to medical treatment, on the clinical, laboratory, anthropometric values, and disease activities of these patients. Materials and Methods: Seventy three children with IBD were evaluated retrospectively. The cases were classified as those who had Crohn disease receiving (CD-M; n = 16) or not receiving Modulen IBD (CD; n = 19) and those who had ulcerative colitis receiving (UC-M; n = 13) or not receiving Modulen IBD (UC; n = 25). Disease activities, laboratory values, remission rates, and anthropometric measurements of the groups were compared. In addition to IBD treatment, Modulen IBD in which half of the daily calorie requirement was provided was given for eight weeks. Results: In the third month of treatment, 14 (88%) patients were in remission in CD-M group and eight (42%) patients were in remission in CD group. The height and weight z scores, which were low at the time of diagnosis, improved in the first week in CD-M group. Inflammatory parameters (UC) were significantly lower in the UC-M group compared to the UC group in first and third months. In the third month, eight (62%) patients in the UC-M group and four (16%) in the UC group were remitted clinically and in terms of laboratory values. Conclusions: TGF-beta-rich enteral nutrition support in children with IBD is an easy, effective, and reliable approach. It was shown that TGF-beta-rich enteral nutritional supplementation enabled the disease to enter the remission earlier, and contributed to the early recovery of weight and height scores.
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    Familial Adenomatous Polyposis: Successful Use of Sirolimus
    (Nature Publishing Group, 2016) Yuksekkaya, Hasan; Yucel, Aylin; Gumus, Meltem; Esen, Hasan; Toy, Hatice
    [Abstract Not Availabe]
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    Gastrointestinal Ulceration in Celiac Disease
    (Lippincott Williams & Wilkins, 2013) Yuksekkaya, Hasan; Gumus, Meltem; Egritas, Odul; Esen, Hasan
    [Abstract Not Availabe]
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    Parvovirus Infection in a Child Complicated with Diabetic Ketoacidosis and Acute Fulminant Hepatitis: a Case Report
    (Aves Yayincilik, Ibrahim Kara, 2017) Eklioglu, Beray Selver; Atabek, Mehmet Emre; Akyurek, Nesibe; Gumus, Meltem
    Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic beta cells. Genetic and environmental factors are believed to be the major component for the development of the disease. Viruses have been suspected to contribute to the onset of T1DM. In this case report, a patient who had diabetic ketoacidosis with acute fulminant hepatitis following asymptomatic infection with parvovirus B19 virus (PB19) is presented. To our knowledge this is the first report of diabetic ketoacidosis (DKA) and acute fulminan hepatitis due to PB19. We suggest close monitoring of the liver functions in DKA and taking care when the liver functions deteriorate.
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    Ursodeoxycholic acid treatment for duodenogastric reflux in childhood
    (Kuwait Medical Assoc, 2021) Agin, Mehmet; Gumus, Meltem; Yucel, Aylin; Yuksekkaya, Hasan Ali; Aydogdu, Sema; Tumgor, Gokhan
    Objective: The purpose of this study was to determine the clinical and histopathological features of duodenogastric reflux (DGR) in children and the effectiveness of ursodeoxycholic acid (UDCA) therapy. Design: Prospective Setting: Cukurova University Medical Faculty Pediatric Gastroenterology Clinic and Necmettin Erbakan University Medical Faculty Pediatric Gastroenterology Clinic, Adana and Konya, Turkey Subjects: One hundred and four children Intervention: One hundred and four patients with DGR were assessed in terms of their history, physical examination, endoscopy, histopathology and response to UDCA therapy. Main outcome measure: Positive results were obtained by administering UDCA treatment in addition to stomach drugs. Results: Eighty-two (79%) patients had previously used various antacids and proton pump inhibitors for dyspeptic symptoms. Gastritis was detected with upper gastrointestinal system endoscopy in all patients. Symptoms decreased by more than half or resolved completely in 97 patients (93%) at the 3-month follow-up interval. Conclusion: DGR should be considered in the etiology of patients with dyspeptic symptoms who fail to respond to antacid and proton pump inhibitor therapy. The majority of patients with DGR responded well to three months of UDCA therapy.