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    Secukinumab-induced Oral Lichen Planus: A Report of Case and Review of Literature
    (Istanbul Training & Research Hospital, 2021) Daye, Munise; Temiz, Selami Aykut; Gumus, Selim; Kilinc, Fahriye
    Recent years, we are witnessing a more frequent use of biological agent treatments. Secukinumab (SEC) has been used successfully in the management of psoriasis, psoriatic arthritis, and ankylosing spondylitis. However, the cases of SEC-related lichen planus (LP) are rarely encountered in the literature. Herein, this report presents a case of oral LP induced by SEC in a 33-year-old patient with psoriasis. In addition, this report aims to review the lichen reactions associated with SEC in the literature. In conclusion, LP cases attributable to SEC use are increasingly being observed in new reports. Clinicians who use SEC in their patients should be aware of this side effect and observe patients in terms of cutaneous-mucosal LP. With the introduction of new interleukin-17 (IL-17) inhibitors, the reporting of side effects is crucial for learning whether LP is class side effects or drug-specific side effects for clarifying pathogenesis. Dermatologists and rheumatologists should be aware of the very rare negative effect of IL-17 inhibitors.
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    Toxic Epidermal Necrolysis in a Patient with Allopurinol, Colchicine and Alcohol Use
    (Emergency Medicine Physicians Assoc Turkey, 2020) Daye, Munise; Temiz, Selami Aykut; Arslan, Sevket; Yosunkaya, Alper; Gumus, Selim; Uyanik, Orkun; Nursen, Hayri Ahmet Burak
    Introduction: Toxic epidermal necrolysis is a severe, acute, mucocutaneous, life-threatening hypersensitivity syndrome with high mortality and bullous lesions on the skin, eyes and mucous membranes. It often develops due to drugs. Sulfonamide group antibiotics and antiepileptic drugs are the most commonly responsible agents. Allopurinol is a common cause of toxic epidermal necrolysis as in most drug reactions. Colchicine is widely used in dermatology and rheumatology and is generally known as an agent with a broad safety profile. Case report: Here we present a case of toxic epidermal necrolysis in our case with allopurinol, colchicine and alcohol use in order to draw attention to the increased risk of drug coexistence. Conclusion: Again, we wanted to draw attention to the management of our case and the efficacy and safety of high-dose intravenous immunoglobulin therapy.