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    Association of Tourette syndrome and obsessive-compulsive disorder with allergic diseases in children and adolescents: a preliminary study
    (Verduci Publisher, 2014) Yuce, M.; Guner, S. N.; Karabekiroglu, K.; Baykal, S.; Kilic, M.; Sancak, R.; Karabekiroglu, A.
    OBJECTIVES: To investigate the rate of allergic diseases including asthma, allergic rhinitis and eczema in children and adolescents diagnosed with obsessive-compulsive disorder (OCD) (n:26) and/or Tourette syndrome (TS) (n:32) [OCD plus TS, n:13] compared to control subjects (n:35) [total, n:80]. PATIENTS AND METHODS: The symptoms of any allergic disease were assessed using the ISAAC questionnaire form. Allergy diagnoses were made by a pediatric allergy specialist. Skin prick tests were applied, and IgE levels and eosinophil counts were measured. RESULTS: While only one-fifth of the control subjects had allergic diseases, more than half of the children with TS and/or OCD had comorbid allergic diseases. Positive skin prick tests were greater in OCD patients compared to control subjects. There were no significant differences between the groups in terms of eosinophil counts or IgE levels. Among the allergic diseases, while allergic rhinitis was diagnosed at significantly higher rates in TS patients, eczema was significantly higher in OCD patients compared to control subjects. CONCLUSIONS: This preliminary study shows an association between allergic diseases and TS and/or OCD. The results revealing differences in associations between types of allergic disease (rhinitis or eczema) and neuropsychiatric disorder (tic disorder or OCD) need to be investigated in further studies with higher numbers of participants, and immune markers should be examined.
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    Bruton disease diagnosed with cervical abscess in early infancy
    (Wiley-Blackwell, 2014) Guner, S. N.; Sayar, Hazar E.; Yin, N. G. Y.; Reisli, I
    [Abstract Not Availabe]
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    CD3G Gene Defects in Familial Autoimmune Thyroiditis
    (Wiley, 2014) Gokturk, B.; Keles, S.; Kirac, M.; Artac, H.; Tokgoz, H.; Guner, S. N.; Caliskan, U.
    The patients with CD3 deficiency can present with different clinical findings despite having the same homozygous mutation. We report three new CD3gamma-deficient siblings from a consanguineous family with a combined T-B+NK+ immunodeficiency and their variable clinical and cellular phenotypes despite the same homozygous mutation of the CD3G gene (c.80-1G>C). We also re-evaluate a previously reported non-consanguineous family with two CD3gamma-deficient siblings with the same mutation. The median age at diagnosis was 11years (14months-20years). We found all five patients to display autoimmunity: autoimmune thyroiditis (n=5), autoimmune haemolytic anaemia (n=2), immune thrombocytopenia (n=1), autoimmune hepatitis (n=1), minimal change nephrotic syndrome (n=1), vitiligo (n=1) and positive antinuclear antibodies (n=3) as well as high IgE (n=2) and atopic eczema (n=2). While CD3(+)TCR+T cell percentages were low in all patients, only one had lymphopenia and 3 had CD3(+)T cell lymphopenia. Strikingly, we report frequent and multiple autoimmunity in tested heterozygous carriers in both families (n=6; in 67%), and frequent autoimmunity in family members not available for testing (n=5, in 80%). The results suggest that CD3G should be studied as a candidate gene for autoimmunity and that CD3gamma deficiency should be considered among other primary immunodeficiencies with predominantly autoimmune manifestations.
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    Education and PID awareness among medical students
    (Wiley-Blackwell, 2014) Reisli, N.; Guner, S. N.; Sayar, Hazar E.; Reisli, I
    [Abstract Not Availabe]
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    Evaluation of the gucocorticoid receptor ? and ? gene expression levels of the perimononuclear cells for vitamin D insufficient children with asthma
    (Wiley-Blackwell, 2013) Guner, S. N.; Sancak, R.; Gulten, S.; Kiic, M.; Bedir, A.
    [Abstract Not Availabe]
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    Eye findings of chronic granulomatous disease: case report
    (Wiley-Blackwell, 2014) Sayar, Hazar E.; Guner, S. N.; Emiroglu, M.; Koker, M. Y.; Reisli, I
    [Abstract Not Availabe]
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    NEW PROGNOSTIC LABORATORY PARAMETERS AND USE OF INTRAVENOUS IMMUNOGLOBULIN G REPLACEMENT FOR SEVERE H1N1 INFECTIONS IN CHILDREN
    (Springer/Plenum Publishers, 2012) Gokturk, B.; Pekcan, S.; Emiroglu, M.; Guner, S. N.; Kirac, M.; Keles, S.; Artac, H.
    [Abstract Not Availabe]
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    A Patient with Combined Immunodeficiency and Hemolytic Anemia
    (Springer/Plenum Publishers, 2014) Sayar, E. Hazar; Guner, S. N.; Emiroglu, M.; De Saint-Basile, G.; Reisli, I.
    [Abstract Not Availabe]