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Öğe Aripiprazole-Induced Sialorrhea Responsive to Diphenhydramine Treatment(Mary Ann Liebert, Inc, 2016) Kilinc, Saliha; Herguner, Arzu; Herguner, Sabri[Abstract Not Availabe]Öğe Association Between Age at Menarche and Autistic Traits in Turkish University Students(Wiley, 2016) Herguner, Arzu; Herguner, SabriObjectives: The androgen theory of autism suggests that masculinizing effect of fetal androgens may play a role in the expression of autism. Recent evidence showed that excessive prenatal androgen exposure might delay age at menarche (AAM). The aim of this study was to investigate the relation between autistic traits and AAM in a sample of non-clinical female university students. Methods: Autistic traits were measured using the Autism Spectrum Quotient (AQ), and AAM was questioned by retrospective self-reports. The AQ was completed by 436 female university students. Results: There were significant positive correlations between AAM and AQ total and subscales measuring Social Skills, Communication, and Imagination. Subjects with above average autistic traits reported later AAM than subjects with below average autistic traits. Conclusion: These findings suggest that there may be a common developmental mechanism between delayed menarche and autistic traits, possibly through elevated levels of prenatal androgens. (C) 2015 Wiley Periodicals, Inc.Öğe Attention deficit hyperactivity disorder symptoms in children with vocal fold nodules(Elsevier Ireland Ltd, 2016) Erdur, Omer; Herguner, Arzu; Ozturk, Kayhan; Kibar, Ertugrul; Elsurer, Cagdas; Bozkurt, Mete Kaan; Herguner, SabriObjectives: The aim of this case-control study was to investigate the symptoms of attention-deficit/hyperactivity disorder (ADHD) in children with vocal fold nodules (VNs). Methods: Study group (SG) included children between 4 and 12 years. As a control group (CG), children between 4 and 12 years without VNs were included in the study. Parents of the participants completed the Conners' Parent Rating Scale-Revised: Short Form (CPRS-RS) which was used to analyze the symptoms of ADHD. Results: Forty-five children (30 boys and 15 girls) with VNs and 45 controls (30 boys and 15 girls) were enrolled in the study. Multivariate analysis of variance revealed that the CPRS-RS Hyperactivity and Oppositional Subscales were significantly higher in the SG than the CG (p < .05), after controlling the effects of age and gender. Conclusions: Our findings suggest associations between VNs and hyperactivity and oppositional behaviors in children. Clinicians should be aware of ADHD symptoms in children with VNs. (C) 2016 Elsevier Ireland Ltd. All rights reserved.Öğe Attention-deficit/hyperactivity disorder symptoms in children with traumatic dental injuries(Wiley-Blackwell, 2015) Herguner, Arzu; Erdur, Aybuke Emire; Basciftci, Faruk Ayhan; Herguner, SabriAim: The aim of this study was to compare the symptoms of attention-deficit/hyperactivity disorder (ADHD) in children with TDIs withto non-injured children. Material and methods: Children between 7 and 16 years old who were admitted to the Selcuk University, Faculty of Dentistry, for treatment of dental trauma were included in the study group (SG). As a control group (CG), children with no reported history of dental trauma were recruited. The Conners' Parent Rating Scale-Revised: Short Form (CPRS-R:S) was used to assess ADHD symptoms. Results: Both groups, SG and CG, composed of 55 children. There were no significant differences in age, gender, and duration of education between SG and CG. Children with TDIs had significantly higher CPRS-R: S Hyperactivity scores. Hyperactivity level was positively correlated with the history of previous dental trauma. There were no associations between number of injured teeth, type of injury, and ADHD symptoms. Conclusions: These findings suggest that children with TDIs have more hyperactive symptoms than children without dental trauma. Clinicians should screen ADHD symptoms in children with TDIs and refer them for treatment when necessary.Öğe Autistic traits in women with polycystic ovary syndrome(Elsevier Sci Ltd, 2012) Herguner, Sabri; Harmanci, Hatice; Herguner, Arzu; Toy, HarunSeveral studies suggested that prenatal androgen exposure might contribute to development of polycystic ovary syndrome (PCOS). The androgen theory of autism proposes that autism spectrum conditions (ASC) are in part due to elevated fetal testosterone levels. Furthermore, higher rates of androgen-related conditions including PCOS are reported in women with ASC. In this study, we aimed to measure the autistic traits in women with PCOS. Forty females who had a diagnosis of PCOS were recruited for the study group. For comparison, 40 healthy age - and Body Mass Index (BMI) - matched women who had regular menses were included. All participants completed the Autism-Spectrum Quotient (AQ). There were no significant differences in age, education, and BMI between groups. Total AQ and communication scores were statistically higher in females with PCOS. Although social skills, imagination, attention to detail and attention switching scores were higher in women with PCOS, these did not reach significance. This study showed that autistic traits were higher in women with PCOS than healthy controls which supports that prenatal exposure to high levels of androgen may be involved in development of ASC. (C) 2012 Elsevier Ltd. All rights reserved.Öğe Combination of Risperidone and Paroxetine for Inappropriate Sexual Behaviors in an Adolescent with Autism and Mental Retardation(Aves, 2012) Herguner, Sabri; Herguner, Arzu; Cicek, ErdincInappropriate hypersexual behaviors have been frequently reported in subjects with autism, however, literature on management of such behaviors in this group is very limited. In this paper, we describe an adolescent with autistic disorder and mental retardation who developed severe inappropriate sexual behaviors and has been treated successfully with risperidone-paroxetine combination. As presence of hypersexual behaviors in individuals with autism is a distressing factor for their family and social environment, appropriate management seems to be essential. (Archives of Neuropsychiatry 2012; 49: 311-313)Öğe Pica in an Adolescent with Autism Spectrum Disorder Responsive to Aripiprazole(Mary Ann Liebert, Inc, 2016) Herguner, Arzu; Herguner, Sabri[Abstract Not Availabe]Öğe Retinal Nerve Fiber Layer Thickness in Children With ADHD(Sage Publications Inc, 2018) Herguner, Arzu; Alpfidan, Ismail; Yar, Ahmet; Erdogan, Erkan; Metin, Ozge; Sakarya, Yasar; Herguner, SabriObjectives: The current study aims to compare retinal nerve fiber layer (RNFL) thickness, macular thickness, and macular volume between children with ADHD and a control group. Method: The study group included children with ADHD and the control group consisted of age- and gender-matched participants without any psychiatric disorder. In all participants, RNFL thickness, macular thickness, and macular volume were measured by using spectral domain-optical coherence tomography (SD-OCT). ADHD symptom severity was evaluated by using parent-report measures, including Conners' Parent Rating Scale-Revised: Short Form (CPRS-R: S) and the Strengths and Difficulties Questionnaire: Parent Form (SDQ: P). Results: We compared 90 eyes of 45 children with ADHD and 90 eyes of 45 controls. ADHD group had significantly lower RNFL thickness only in nasal quadrant than the controls. The remaining RNFL quadrants, macular thickness, and volume were not significantly different between groups. There was a reverse correlation between RNFL thickness and ADHD symptom severity. Conclusion: This is the first study examining the RNFL thickness in ADHD. Our findings showed that nasal RNFL thickness was lower, indicating reduced unmyelinated axons in the retina of children with ADHD. The results of this study support the evidence that ADHD involves a lag in cortical maturation and this is measurable in the retina.
