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Öğe Assessment of ELR, NLR, MPV, and CRP Levels in Patients With Acne Vulgaris(Galenos Publ House, 2022) Daye, Munise; Temiz, Selami Aykut; Ozturk, Elif Nur Yildirim; Isik, BegumBACKGROUND/AIMS: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. The relationship between some of the hematological parameters active in inflammation such as the neutrophil/lymphocyte ratio (NLR), the mean platelet volume (MPV), and C-reactive protein (CRP) has been demonstrated. In recent years, eosinophil cells have been shown to be associated with inflammation, and the eosinophil/lymphocyte ratio (ELR) has been shown to be an indicator of inflammation in some diseases. In this study, we aimed to evaluate the relationship between the ELR, NLR, MPV, and CRP levels, which are indicators of systemic inflammation, with acne severity parameters in patients with acne vulgaris. MATERIALS AND METHODS: A prospective study was planned with patients in our clinic who were diagnosed with acne vulgaris, who required routine blood parameters, and whose global acne score was calculated. The relationship between these parameters, which are an indicator of systemic inflammation and acne severity, was investigated. RESULTS: In our findings, MPV was found to be the strongest hematological marker for acne severity and inflammation. There was a significant difference between acne severity and ELR, and this difference was higher in the severe acne group. CONCLUSION: As far as we are aware, there has been no study on ELR levels in acne to date; this is the first study to evaluate this rate. Based on our findings, it is thought that ELR increases with the severity of acne and can be accepted as an indicator. In this context, we believe that there is a need for controlled studies involving the role of eosinophils in blood, tissue, and inflammation in the pathogenesis of acne. It is possible that the role of eosinophils in pathogenesis will explain itch-dominated acne patients and may also lead to the development of new targets for treatment.Öğe Does omalizumab use in chronic spontaneous urticaria results in improvement in sexual functions?(Wiley, 2022) Durmaz, Koray; Ataseven, Arzu; Temiz, Selami Aykut; Isik, Begum; Dursun, RecepBackground Chronic spontaneous urticaria (CSU) is a disease that can affect the patient's quality of life (QoL), sexual functions, and mood. Objective We planned a retrospective study to investigate the effects of omalizumab use in CSU patients on sexual function. We also aimed to evaluate the sexual function, quality of life (QoL), and mood of CSU patients compared to the control group consisting of idiopathic pruritus patients. Methods A review of patients' records with CSU attending the dermatology outpatient clinic from January 2020 to June 2020 was done. Urticaria activation score (UAS7), Beck depression inventory (BDI), Dermatology life quality index (DLQI), female sexual function index (FSFI) to female participants, and the international index of erectile function (IIEF) to male participants were used to assess the impact of the disease on patients' life. The obtained data were analyzed by using SPSS software. Results Each one of the mean UAS, BDI, and DLQI score values decreased significantly in weeks in omalizumab group patients. IIEF score in male patients and FSFI score in female patients also increased in weeks in omalizumab group patients. Conclusions Omalizumab can play an effective role in enhancing the sexual function of CSU patients in addition to improving their DLQI.Öğe The effect of 577-nm pro-yellow laser on demodex density in patients with rosacea(Wiley, 2022) Temiz, Selami Aykut; Durmaz, Koray; Isik, Begum; Ataseven, Arzu; Dursun, RecepBackground The pro-yellow laser is a yellow light wavelength (577-nm) laser system. Rosacea is a chronic inflammatory disorder that occurs with facial flushing, erythema, papules, pustules, and telangiectasia. Demodex parasites (Demodex folliculorum and brevis) also play a role in the pathogenesis of rosacea. Aim The aim of our study is to evaluate the effect of pro-yellow laser on demodex density (Dd) in patients with rosacea. Patients/Methods This retrospective study was planned for the patients with rosacea whose demodex mite densities were examined and treated with pro-yellow laser and were evaluated between 2019 and 2020 in the cosmetology unit. The laser light was applied at a dose of 20 J/cm(2) in the scanner mode (the 80% coverage) in all the patients. The demodex density per cm(2) was routinely evaluated before the treatment, and the demodex density values in the fourth week after the treatment were recorded from the patients' files. Results There were 27 females (79.4%) and seven males (20.6%) evaluated in the study. While the demodex density was 18.1 +/- 10.7 (min: 0-max: 48, Q1:12-Q3:22) per cm(2) before the pro-yellow laser treatment in the cases, the demodex density was 10.2 +/- 7.9 (min: 0-max: 30, Q1:4.75-Q3:12) per cm(2) in the fourth week after the treatment. After the pro-yellow laser treatment, the demodex intensity decreased significantly compared to before the laser treatment (p = 0.001). There was no significant correlation between the decrease in the density of the demodex mite and the success of the treatment (p = 0.46). Conclusion This is the first study in the literature investigating the change in demodex density in rosacea patients treated with pro-yellow laser therapy. In this study, it was shown that pro-yellow laser treatment is effective in reducing the density of demodex.Öğe Effect of the COVID-19 pandemic on the anxiety and depression levels in patients who applied to the cosmetology unit(Wiley, 2021) Temiz, Selami Aykut; Durmaz, Koray; Dursun, Recep; Ataseven, Arzu; Isik, Begum; Karaagac, Onur; ozer, IlkayThe relationship between the skin and the brain is based on their origin from the same ectodermal structure, as well as being affected by similar hormones and neurotransmitters. At this point, psychodermatology forms a common field of study based on the relationship and interaction between psychiatry and dermatology. Cosmetology is a special group within dermatology, and the psychosocial needs of this group differ. In this study, it was aimed to examine the moods such as anxiety, fear and depression experienced by the patients during their application to the cosmetology unit during the COVID-19 pandemic process and to compare them with the control group. A total of 162 cases, 80 cases from the cosmetology unit meeting the specified conditions and 82 cases as the control group, were retrospectively evaluated. In all participants, the Coronavirus Anxiety Scale (CAS) scores decreased significantly compared to the beginning of the pandemic (P = .001). In the study, while depression (HAM-D) and general anxiety (HAM-A) were higher in the cosmetology group compared to the control group (P = .049 and P = .001, respectively), there was no difference in coronavirus anxiety scores (CAS) (P = .24). It should be known that patients who underwent cosmetological procedures during the pandemic period may have anxiety and depression. In this patient group, which requires a special psychodermatological approach, pandemic effects should also be considered. In patients who apply to cosmetology units during the pandemic period, attention should be paid to the relationship between surreal cosmetological process requests and their anxiety and depression state.Öğe Evaluation of bowel habits in patients with acne vulgaris(Wiley, 2021) Daye, Munise; Cihan, Fatma Goksin; Isik, Begum; Hafizoglu, BernaPurpose To evaluate the bowel habits of patients with acne vulgaris. Method In this case-control study, socio-demographical characteristics of the participants (age, gender, marital status, educational status, profession, economic status, smoking-alcohol habits, chronic diseases, previous operations, people they live with and diet) were questioned and the global acne grading scores of the patients were calculated. Bristol Stool Scale, Rome III IBS Criteria, International Physical Activity Questionnaire-Short Form, Hospital Anxiety Depression and KADF (dietary fibre information) scales were completed. Results The patient group consisted of 102 participants and the control group consisted of 104 participants. The mean age was 20.9 +/- 3.9 years old in the case group and 21.8 +/- 5.0 years old in the control group. Patient and control groups were similar in terms of age and gender. Smoking rates were significantly higher in the patient group (P = .035). The amount of coffee consumed/day was significantly higher in the patient group (P = .040). According to the global acne grading scores, 55.9% (n = 57) had medium, 39.2% (n = 40) had mild, 3.9% (n = 4) had severe and 1% (n = 1) had very severe acne. Anxiety scores were found to be significantly higher in the patient group (P = .005). When the case and control groups were compared for IBS presence, no significant difference was found (P = .317). Also, IBS was not related to acne severity (P = .162). Conclusion Further large sample sized studies are needed on this subject, as there is strong evidence about brain-gut-skin axis existence.Öğe Evaluation of the effect ofCOVID-19 pandemic on dermatological diseases with dermatological quality life index(Wiley, 2020) Daye, Munise; Temiz, Selami Aykut; Isik, Begum; Dursun, Recep; Ataseven, ArzuDisease-related skin lesions have been reported in 8% to 20% of COVID-19 patients. In the literature, cutaneous symptoms associated with the disease are generally emphasized. However, there are very few studies on the effect of this new SARS-CoV-2 virus entering our lives on dermatological diseases, and none of them have used the dermatological quality of life index (DLQI). In our study, we aimed to evaluate the difficulties faced by the patients who applied to the dermatology outpatient clinic during the pandemic period and the course of their diseases with the dermatological quality of life index. The study was carried out prospectively by including dermatology patients who will apply to the outpatient clinic in June-July 2020. 282 patients were evaluated in the study. DLQI was significantly lower in the group using regular emollients (P < .001). When DLQI was compared between disease groups, it was found to be significantly different (P: .017). DLQI was found to worsen significantly compared to prepandemic studies. It was found that using moisturizer in this period helps to maintain the dermatological quality of life.Öğe Is Gardner-Diamond syndrome related to autoimmunity?(Kare Publ, 2021) Temiz, Selami Aykut; Isik, Begum; Ozer, Ilkay; Ataseven, ArzuGardner and Diamond described a clinical picture of painful ecchymosis in the skin and mucous membranes in four female patients and called this entity Gardner-Diamond syndrome (GDS). At present, the exact pathogenesis of the disease is still unknown. In recent years, it has been advocated that antibodies against phosphatidylserine in erythrocyte stroma may cause immune complex and complement activation, leading to this clinical picture. Herein, we found it appropriate to present a case of multiple ecchymotic lesions diagnosed with GDS followed by many autoimmune diseases to draw attention to autoimmune association. As a result of this case presentation and mini-literature review, we think that autoimmunity patients should not be missed in GDS patients.Öğe Is Gardner-Diamond syndrome related to autoimmunity?(Kare Publ, 2021) Temiz, Selami Aykut; Isik, Begum; Ozer, Ilkay; Ataseven, ArzuGardner and Diamond described a clinical picture of painful ecchymosis in the skin and mucous membranes in four female patients and called this entity Gardner-Diamond syndrome (GDS). At present, the exact pathogenesis of the disease is still unknown. In recent years, it has been advocated that antibodies against phosphatidylserine in erythrocyte stroma may cause immune complex and complement activation, leading to this clinical picture. Herein, we found it appropriate to present a case of multiple ecchymotic lesions diagnosed with GDS followed by many autoimmune diseases to draw attention to autoimmune association. As a result of this case presentation and mini-literature review, we think that autoimmunity patients should not be missed in GDS patients.Öğe Isotretinoin-induced hair disorders in the era of COVID-19 and related vaccines: A case series(Wiley, 2022) Abdelmaksoud, Ayman; Temiz, Selami Aykut; Dursun, Recep; Wollina, Uwe; Rudnicka, Lidia; Isik, Begum; Lotti, Torello[Abstract Not Availabe]Öğe Relationship between acanthosis nigricans, acrochordon and metabolic syndrome in patients with lichen planus(Wiley, 2021) Daye, Munise; Temiz, Selami Aykut; Isik, Begum; Durduran, YaseminAim In the literature, there are no data examining the association with lichen planus with acanthosis nigricans and acrochordon, which are skin findings of metabolic syndrome (MS). Materials A total of 108 lichen planus (LP) patients, age and sex-matched 109 controls, 217 patients in total were prospectively included in the study. Results Metabolic Syndrome was found in 55 (50.9%) of 108 patients with lichen planus and 36.7% in the control group. The frequency of MS in the lichen planus group was found to be significantly higher than that in the control group (P = .03). The incidence of acanthosis nigricans (AN) was statistically higher in the LP group (P = .009). In addition, while 38 of 47 AN patients in the LP group had MS, 17 of 61 patients without AN had MS, and the presence of MS was found significantly higher in LP patients with AN (p<0.001). The incidence of acrochordon was statistically higher in the LP group (P = .03). In addition, while 43 of 62 patients with acrochordon in the LP group had MS, 12 of 46 patients without acrochordon had MS, and the presence of MS was found significantly higher in patients with LP with acrochordon (P < .001). Conclusion In our study, it was found that skin findings such as AN and acrochordon increased in patients with lichen planus. This increase was also observed in lichen planus patients with metabolic syndrome. Therefore, the association of acanthosis nigricans and acrochordon may be a predictive of metabolic syndrome in patients with lichen planus admitted to the dermatology outpatient clinic.Öğe The relationship between lichen planus and metabolic syndrome(Wiley, 2021) Daye, Munise; Temiz, Selami Aykut; Isik, BegumObjective Lichen planus (LP) is an idiopathic, chronic inflammatory disease. Chronic inflammatory diseases can cause metabolic complications. In the literature, data related to the relationship between lichen planus and metabolic syndrome (MS) are limited. We aimed to evaluate the relationship between MS and lichen planus with disease activity. Methods The patients diagnosed with lichen planus at the dermatology outpatient clinic between January 2018 and January 2020 were retrospectively analyzed. 98 lichen planus cases, age- and sex-matched 99 controls, 197 cases in total were included in the study. Results Of the 98 lichen planus cases included in the study, 60 (61%) were women. The mean age of the patients was 49.3 +/- 14.4, and the average disease duration was 33.5 +/- 31.4 months. 55 (55%) of the patients in the control group were female, and the mean age of the control group was 50 +/- 13.2. The body mass index of LP cases was 29.5 +/- 5.8, in the control group was 25.8 +/- 3.7. Metabolic syndrome was found in 47 (48%) of 98 cases with lichen planus and 32.3% in the control group. MS in the lichen planus group was significantly higher than the control group (P = .025). Metabolic syndrome was detected in the oral lichen planus at the rate of 60% (12 cases). Although the incidence of MS was more common in the oral lichen planus, it was not statistically significant (P = .29). While no significant relationship was found between oral disease severity and metabolic syndrome (P = .19), a significant correlation was found between cutaneous disease severity and metabolic syndrome (P = .023). Discussion The risk of mucosal malignancy that can occur when following LP cases has been known for a long time. According to our results, caution should be taken in terms of metabolic complications in the follow-up of LP cases, especially oral LP cases.
