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    Sensitive and selective determination of paracetamol in antipyretic children's syrup with a polyglycine modified glassy carbon electrode
    (Royal Soc Chemistry, 2023) Islamoglu, Nesim; Mulazimoglu, Ibrahim Ender; Mulazimoglu, Aysen Demir
    A sensitive and selective electrochemical sensor for the determination of paracetamol (acetaminophen) is proposed based on a polyglycine-coated glassy carbon electrode. The electrochemical behavior of paracetamol was studied by cyclic voltammetry and differential pulse voltammetry. Under optimal experimental conditions, the peak oxidation current of paracetamol increases linearly in the range of 0.5-75 & mu;M. The limit of detection of paracetamol was 0.03 & mu;M and the limit of quantitation was 0.09 & mu;M. In addition, modified glassy carbon with polyglycine as the sensor was successfully used for the determination of paracetamol in antipyretic children's syrup samples, with a recovery rate of over 95.3%, showing its great application potential in drug analysis.
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    Use of guanine-modified glassy carbon electrode as an electrochemical sensor for the determination of paracetamol
    (Bangladesh Pharmacological Soc, 2023) Islamoglu, Nesim; Mulazimoglu, Ayen Demir
    In this study, guanine-modified glassy carbon electrode sensor was developed for the determination of paracetamol. The use of overdose continuously for a long time, its metabolites accumulate and affect the kidneys and liver. There-fore, the detection of paracetamol is of great significance. Differential pulse voltammetry and cyclic voltammetry techniques were employed to analyze the behavior of paracetamol in 0.1 M Britton-Robinson buffer solution of pH 5.0 on guanine-modified electrode. Guanine-modified glassy carbon electrode showed a good linear response in the concentration range from 0.5 mM to 10 & mu;M for the quantitative determination of paracetamol with the lower limit of detection of 0.9 & mu;M.