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    Atopy and allergic diseases in immunoglobulin A deficiency
    (Bilimsel Tip Yayinevi, 2012) Artac, Hasibe; Keles, Sevgi; Karagol, Cuneyt; Gokturk, Bahar; Reisli, Ismail
    Objective: Immunoglobulin (Ig) A deficiency is a common immune system disorder which causes morbidity especially in preschool children. The aim of this study is to evaluate atopy and allergic diseases of cases with IgA deficiency, determinate clinical results before and after four years of age. Materials and Methods: The data records of 295 children with IgA deficiency (272 partial, 23 selective IgA deficiency) between November 2001 and 2007 were examined retrospectively. Results: The mean age at the diagnosis was 64.3 +/- 43 (4-204) months, the mean age at the beginning of infection was 29.5 +/- 36 (1-168) months. There were 121 patients under the age of four years at the diagnosis time. The clinical presentations were recurrent bronchitis (40%), tonsillitis/pharyngitis (33%), sinusitis (6%), pneumonia (4%), acute otitis media (2%), acute gastroenteritis (0.3%) and neck abscess (0.3%), respectively. Eosinophilia was present in 25% of patients, increased IgE levels was present in 38% of patients, and they were correlated with each other. Atopy was detected in 31% of patients by spesific IgE and/or skinprick test positivity. Allergic disease prevalance was found as % 78 (60% asthma, 15% allergic rhinitis, 8% atopic dermatitis, 6% urticaria, 0.7% allergic conjunctivitis). During the clinical follow-up IgA levels reached to normal levels at 17 +/- 14 months ranged between 3 and 60 months. Three patients with selective IgA deficiency had bronchiectasia. Conclusion: We found that allergic diseases were increased in these patients. Serum IgA level should be tested not only for recurrent infections but also for patients with allergic symptoms.
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    Clinical features and risk factors in children with acute asthma attack
    (Bilimsel Tip Yayinevi, 2012) Karagol, Cuneyt; Ertoy Karagol, Hacer Ilbilge; Keles, Sevgi; Artafc, Hasibe; Reisli, Ismail
    Objective: Asthma is one of the most common chronic diseases in childhood and has a high prevalence, morbidity and mortality. Acute asthma attacks are the most significant factor in the determination of the mortality and morbidity of asthma. The aim of this study was to evaluate the risk factors, clinical characteristics and the response of treatment of asthma attacks in children. Patients and Methods: Between January 2008 and January 2009, the clinical characteristics and laboratory findings of 40 children with asthma attack were evaluated. Results: Of 40 children consisting of the study group, 23 were boys and 17 were girls. Mean age was found to be 7.8 +/- 1.9 years. While the most significant risk factors causing attacks were determined as infections and exposure to cigarette smoking, coughing was found as the most frequent symptom during attacks. The severity of the asthma attacks as follows: mild attacks in 20 (50%), moderate attacks in 18 (45%) and severe attacks in 2 (5%) of the patients, respectively. According to the severity of the attacks and response to the treatment, systemic steroid therapy was required in the treatment of 16 (40%) patients while 24 patients improved only with oxigen and short-acting bronchodilator. After the treatment in the emergency unit, 34 (85%) patients were discharged to home and 4 (10%) were hospitalized in the department of pediatrics and 2 (5%) into the intensive care unit. Conclusion: The determination of the risk factors of acute exacerbation is very important to reduce the frequency and the severity of the asthma attacks. We think that the education of the family is necessary to prevent the children with asthma from exposure to smoking and infections.