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Öğe Alterations of the thioredoxin system during subarachnoid hemorrhage-induced cerebral vasospasm(Springer Wien, 2015) Kaya, B.; Erdi, F.; Kilinc, I.; Keskin, F.; Feyzioglu, B.; Esen, H.; Karatas, Y.The exact underlying pathogenic mechanisms and effective preventive or therapeutic interventions for cerebral vasospasm remain obscure. The thioredoxin (Trx) system performs important functions in the central nervous system including neurotrophic and neuroprotective actions. There is no study directly investigating the effects of subarachnoid hemorrhage (SAH) induced cerebral vasospasm on the Trx system in the literature. Sixteen male New Zealand rabbits were randomly divided into two groups of eight rabbits each: a control group and a SAH group. The control group, (n = 8) was a sham surgery group in which SAH was not induced. In the SAH group, (n = 8), the SAH protocol was used to induce cerebral vasospasm. The brain and brainstem were removed and each brainstem was cut coronally into two pieces: an anterior part that contains basilar artery and a dorsal part that contains brainstem tissue. The brainstem tissue thioredoxin-1(Trx1), thioredoxin-2 (Trx2), thioredoxin reductase (TrxR), thioredoxin reductase-1 (TrxR1), thioredoxin-interacting protein (TXNIP) levels were investigated. Total oxidant status (TOS), total antioxidant status (TAS), malondialdehyde levels (MDA) and tumor necrosis factor alpha (TNF-alpha) levels were investigated for determining the oxidative-antioxidative status of the related brain tissues. Basilar artery segments were investigated for cross-sectional area and wall thickness measurements. SAH statistically significantly reduced the tissue levels of Trx1 (p < 0.01) and TrxR (p < 0.01). Trx2 levels were not significantly altered after SAH (p > 0.05). SAH significantly reduced the expression of TrxR1 (p < 0.01) and significantly increased the expression of TXNIP (p < 0.01) when compared with controls. TOS levels and MDA levels significantly increased after SAH (p < 0.01) and TAS levels significantly reduced after SAH (p < 0.01). TNF-alpha levels significantly increased after SAH (p < 0.01). SAH-induced cerebral vasospasm significantly (p < 0.05) increased the wall thickness and reduced the mean cross-sectional area of the basilar artery (p < 0.05). The Trx system seems to be negatively affected by the simultaneously interrelated enzymatic alterations during cerebral vasospasm.Öğe Chronic myeloid leukemia detected on FDG PET/CT imaging in a patient with renal cell carcinoma(Elsevier Doyma Sl, 2013) Varoglu, E.; Kaya, B.; Sari, O.It is well known that hematopoietic cytokine stimulation can cause increased fluorodeoxyglucose (FDG) accumulation in bone marrow on PET/CT imaging, which simulates that seen in patients with bone marrow metastases. However, increased bone marrow FOG uptake can be caused by other etiologies. We report a patient with operated renal cell carcinoma had no history of hematopoietic cytokine stimulation. The FDG PET/CT images showed increased bone marrow FDG uptake, and the patient was diagnosed as chronic myeloid leukemia. This case revealed that increased FDG uptake on bone marrow may be related to neoplastic disease of the hematopoietic tissues. (C) 2012 Elsevier Espana, S.L. and SEMNIM. All rights reserved.Öğe Evaluation of hepatic metabolic activity in non-alcoholic fatty livers on 18FDG PET/CT(Elsevier Doyma Sl, 2013) Dostbil, Z.; Varoglu, E.; Serdengecti, M.; Kaya, B.; Onder, H.; Sari, O.Objective: The liver has been used as a reference organ for the assessment of abnormal F-18-fluoro-2-deoxy-D-glucose ((18)FDG) in the body. Some researchers found that hepatosteatosis significantly changed the hepatic (18)FDG uptake, while others did not. This study investigated whether the liver's (18)FDG uptake was affected by the diffuse fatty infiltration of the liver. Material and methods: A total of 156 cases were included in this study. Different patient groups were defined according to the liver Hounsfield unit (HU). The HU was calculated from an unenhanced CT, for all patients, and we calculated the mean standardized uptake value (STmean) and maximum standardized uptake value (SUNmax) on an (18)FDG PET scan. For this purpose, we placed regions of interest (ROIs) on the liver image. We statistically compared the SUVmean and SUVmax measured in the fatty liver patients and the control group. Results: The average SUVmean and SUVmax values were calculated as 2.58 +/- 0.66 and 3.94 +/- 1, respectively, in the patient group and 2.54 +/- 0.57 and 3.7 +/- 0.88, respectively, in the control group. We found the average SUVmean and SUVmax values in the fatty liver group and its subsets were not significantly different from the values in the control group (p > 0.05). We also did not find any statistically significant correlation between average liver density (HU) and the average SUV values (p > 0.05). Conclusion: Fatty infiltration may not have a significant effect on the liver's (18)FDG uptake. Thus, the liver may be used as a reference or comparator on (18)FDG PET scans in patients with fatty liver disease. (C) 2012 Elsevier Espana, S.L. and SEMNIM. All rights reserved.Öğe FDG PET/CT findings of thyrotoxicosis induced thymic hyperplasia associated to interferon(Elsevier Doyma Sl, 2013) Gedik, G. K.; Sari, O.; Kaya, B.; Varoglu, E.[Abstract Not Availabe]Öğe Is Dual Time Point Imaging Necessary For Discrimination of adrenal benign lesions versus malignant masses: A Study Comparing Standart Methods with Dual Time Point FDG PET-CT Imaging(Springer, 2016) Kara, P. Ozcan; Koc, Z.; Kara, T.; Kaya, B.[Abstract Not Availabe]Öğe Lymphangitic Carcinomatosis in the Nonsmall Cell Lung Cancer Detected on FDG-PET/CT(Springer, 2012) Serdengecti, M.; Varoglu, E.; Kaya, B.; Sari, O.; Guler, T.; Ozbek, O.; Keskin, S.[Abstract Not Availabe]Öğe Mercaptoacetyltriglycine renal scan for the differential diagnosis of acute tubular necrosis and interstitial nephritis associated to vancomycin(Elsevier Doyma Sl, 2012) Gedik, G. K.; Yilmaz, F.; Kaya, B.; Kara, P. O.; Sari, O.The differential diagnosis of vancomycin associated renal toxicity includes acute tubular necrosis and interstitial nephritis. We report a case of vancomycin induced renal toxicity shown by Tc-99m mercaptoacetyltriglycine renal scan. Nephrotoxicity was evolved secondary to vancomycin used for treating a patient with meningitis. Tc-99m mercaptoacetyltriglycine renal scan may play a role in differentiation between acute tubular necrosis and tubulointerstitial nephritis of vancomycin associated renal toxicity and can facilitate the clinical decision making. (C) 2011 Elsevier Espana, S.L. and SEMNIM. All rights reserved.Öğe Our Trans-Thoracic Biopsy Practices Accompanied By The Imaging Process: The Contribution Of Positron Emission Tomography Usage To Accurate Diagnosis(Amer Thoracic Soc, 2016) Intepe, Y.; Metin, B.; Sahin, S.; Kaya, B.; Okur, A.[Abstract Not Availabe]
