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Öğe Comparison of embryo morphokinetics following intracytoplasmic sperm injection in smoker and non-smoker couples: Are the results different?(Pakistan Medical Assoc, 2017) Salvarci, Ahmet; Gurbuz, Ali Sami; Uzman, Sukru; Kaya, Melek; Gorkemli, HuseyinObjective: To assess early embryo development via time-lapse in smokers and non-smokers. Methods: The retrospective study was conducted at Novafertil IVF centers in Konya, Turkey and comprised oocytes of both smoker and non-smoker couples subjected to in vitro fertilisation /introcytoplasmic sperm injection from 2012 to 2015. Age, basal follicle-stimulating hormone, number of stimulation days, amount of gonadotropin used, number of metaphase II oocytes, number of embryos transferred and pregnancy, abortus and clinical pregnancy rates were noted. The embryos were observed for 72 hours in the time-lapse monitoring system. SPSS 22 was used for data analysis. Results: Of the 257 couples, 132(51.4%) were non-smokers and 125(48.6%) were smokers. A total of 1,414 oocytes were collected from non-smokers and 1,280 oocytes from smokers. There was no significant difference in the age of patients and number of stimulation days between the smoker and non-smoker groups (p>0.05). The number of oocytes, fertilised oocytes, transferred embryos and metaphase II oocytes was significantly less in the smoker group (p<0.05). The rate of pregnancy and ongoing pregnancy was also lower in the smoker group (p<0.05)smoker and non-smoker groups (p<0.05). A prolongation was observed in time to pronuclear fading. A difference was observed in time of pronuclei appearance, t8, t9+ cleavage times in time-lapse in the and t2 cleavage times in time-lapse in the non-smoker group (p<0.05). Some chromosomal number and structural defects were identified in preimplantation genetic in some embryos with prolongation in time-lapse cleavage time in the smoker and nonsmoker groups. Conclusion: The negative impacts of smoking were not observed at each cleavage phase of embryo development in time-lapse.Öğe GnRH agonist triggering affects the kinetics of embryo development: a comparative study(Biomed Central Ltd, 2016) Gurbuz, Ali Sami; Gode, Funda; Uzman, Mehmet Sukru; Ince, Betul; Kaya, Melek; Ozcimen, Necati; Ozcimen, Emel EbruBackground: To evaluate the effects of an ovulation triggering agent, human chorionic gonadotropin (hCG), versus a gonadotropin-releasing hormone agonist (GnRHa) on early embryo development in vitro using a time-lapse system. Methods: Retrospective analysis of a prospectively collected database. A total of 739 embryos from 152 infertile couples undergoing intracytoplasmic sperm injection cycles. Interventions : Embryo culture in a time-lapse incubator (EmbryoScope, Vitrolife, Goteborg, Sweden). Main Outcome Measures: Embryo morphokinetic parameters. Results: In the 152 women, 252 embryos were derived from GnRHa-triggered cycles compared with 487 embryos derived from hCG-triggered cycles. Time-lapse analysis revealed that embryos from cycles triggered by a GnRHa cleaved faster than embryos derived from hCG-triggered cycles. Conclusion: Triggering with a GnRHa in in vitro fertilization cycles affects embryo kinetics.Öğe GnRH agonist triggering affects the kinetics of embryo development: a comparative study(Biomed Central Ltd, 2016) Gurbuz, Ali Sami; Gode, Funda; Uzman, Mehmet Sukru; Ince, Betul; Kaya, Melek; Ozcimen, Necati; Ozcimen, Emel EbruBackground: To evaluate the effects of an ovulation triggering agent, human chorionic gonadotropin (hCG), versus a gonadotropin-releasing hormone agonist (GnRHa) on early embryo development in vitro using a time-lapse system. Methods: Retrospective analysis of a prospectively collected database. A total of 739 embryos from 152 infertile couples undergoing intracytoplasmic sperm injection cycles. Interventions : Embryo culture in a time-lapse incubator (EmbryoScope, Vitrolife, Goteborg, Sweden). Main Outcome Measures: Embryo morphokinetic parameters. Results: In the 152 women, 252 embryos were derived from GnRHa-triggered cycles compared with 487 embryos derived from hCG-triggered cycles. Time-lapse analysis revealed that embryos from cycles triggered by a GnRHa cleaved faster than embryos derived from hCG-triggered cycles. Conclusion: Triggering with a GnRHa in in vitro fertilization cycles affects embryo kinetics.