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    Antibacterial nano cerium oxide/chitosan/cellulose acetate composite films as potential wound dressing
    (Pergamon-Elsevier Science Ltd, 2020) Kalaycioglu, Zeynep; Kahya, Nilay; Adimcilar, Veselina; Kaygusuz, Hakan; Torlak, Emrah; Akin-Evingur, Gulsen; Erim, F. Bedia
    Novel chitosan and cellulose acetate polymer composites with nanosized cerium oxide were prepared as potential wound dressing materials. Chitosan and cellulose acetate are natural polymer derivatives with biocompatible properties. Both polymers can be dissolved in formic acid. The polymer composite was formed by solvent-casting method. The formed films were not soluble in water. In order to improve antibacterial, thermal, and mechanical properties of the composite material, films were loaded with nanosized cerium oxide. Films were characterized with thermogravimetric, scanning electron microscopy with energy-dispersive X-ray spectroscopy, mechanical, ultraviolet-visible light transmittance, water solubility, pH, moisture content, water vapor transmission rate, swelling, and antibacterial tests. The physical properties and antibacterial characteristics of the films are promising for further research as a potential wound covering material.
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    Antimicrobial cerium ion-chitosan crosslinked alginate biopolymer films: A novel and potential wound dressing
    (Elsevier Science Bv, 2017) Kaygusuz, Hakan; Torlak, Emrah; Akm-Evingur, Gulsen; Ozen, Ilhan; von Klitzing, Regine; Erim, F. Bedia
    Wound dressings require good antiseptic properties, mechanical strength and, more trustably, natural material ingredients. Antimicrobial properties of cerium ions and chitosan are known and alginate based wound dressings are commercially available. In this study, the advantages of these materials were combined and alginate films were crosslinked with cerium(III) solution and chitosan added cerium(III) solution. Films were characterized by Fourier transform infrared spectroscopy (FTIR), light transmittance, scanning electron microscopy (SEM), swelling expefiments, water vapor transmittance tests, and mechanical stretching tests. The antibacterial and physical properties of the films were compared with those of conventional calcium alginate films. Both cerium ion crosslinked and cerium ion-chitosan crosslinked alginate films gained antibacterial activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. Cerium alginate-chitosan films showed high resistance to being deformed elastically. Results show that cerium alginate-chitosan films can be flexible, ultraviolet protecting, and antibacterial wound dressings. (C) 2017 Elsevier B.V. All rights reserved.