Yazar "Khalili, Yeganeh" seçeneğine göre listele

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    Effects of Quinoa (Chenopodium quinoa) on inflammatory mediators: a systematic review of preclinical studies
    (Springer Basel Ag, 2023) Mahdavi, Aida Malek; Javadivala, Zeinab; Khalili, Yeganeh; Khalili, Majid
    The aim of the current systematic review was to gather the researches about the effect of quinoa (chenopodium quinoa) on inflammatory parameters interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha). Search was performed using PubMed, Scopus, WOS, ProQuest, and Google scholar databases without any restriction on language or publication date until July 2022 and search alert services were used to detect novel papers published after the initial search. Only 20 animal and in vitro investigations were eligible for this systematic review. According to in vitro researches and 8 of 14 animal investigations, IL-6, IL-1 beta, and TNE-alpha level decreased remarkably after quinoa administration, which indicates the capability of quinoa in alleviating inflammatory factors. Quinoa is favorable but not yet a confirmed agent for alleviating systemic inflammation in inflammatory diseases.
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    Effects of Trigonella foenum graecum (fenugreek) on rheumatoid arthritis: a systematic review
    (Taylor & Francis Ltd, 2023) Faghfoori, Zeinab; Javadivala, Zeinab; Khalili, Yeganeh; Mahdavi, Aida Malek
    BackgroundAdjuvant therapies especially medicinal plants have gained lots of attention nowadays and have been consumed all over the world for treating different diseases particularly rheumatoid arthritis (RA). Recent animal studies have indicated the benefits of fenugreek in RA and indicate that it may be a therapeutic candidate in RA; nonetheless, no systematic review is available about fenugreek and RA. This paper systematically reviewed the existing studies about fenugreek and RA and plausible mechanisms.MethodsDatabases including PubMed, Scopus, Web of Science, ProQuest, and the search engine Google Scholar were searched until May 2022 and search alerts were used to receive studies issued after the primary search. There was no restriction in time and/or language. No human and in vitro research was detected; thus, animal investigations were considered. Also, the citations or references of studies were searched for potential studies. Book chapters, review papers, and grey literature (e.g. conference abstracts, dissertations, and patents) were not included.ResultsFinally, 11 studies were entered in this systematic review. Animal investigations showed that fenugreek had favorable effects in RA and could control this disease via attenuating inflammation, suppressing oxidative stress, and displaying anti-arthritic activity.ConclusionCurrent review provides potent evidences about the efficacy of fenugreek in RA and elucidates the significance of more clinical investigations.
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    An introduction to EpiPol (Epigenetic affecting Polymorphism) concept with an in silico identification of CpG-affecting SNPs in the upstream regulatory sequences of human AHR gene
    (Elsevier, 2020) Aftabi, Younes; Khoshkam, Zahra; Amiri-Sadeghan, Amir; Khalili, Yeganeh; Ichihara, Gaku
    DNA methylation, histone modification, and ncRNA function are the main epigenetic mechanisms involved in the regulation of gene expression and there are single nucleotide polymorphisms (SNPs) that may affect them. Although these SNPs have an important role in connecting genetic and epigenetic levels of gene regulation, they have not been classified in an independent category until now. Therefore, we introduce the EpiPol concept, which abbreviates the epigenetic affecting polymorphism and describes those variations in the regulatory se-quences of a gene, which may affect epigenetic regulations of its expression. Aryl hydrocarbon receptor (AHR) is a multifunctional regulator in cell physiology and xenobiotics metabolism and its altered regulation have been shown to result in adverse developmental and physiological outcomes. Recently, the therapeutic potential of modulating the methylation status of the AHR promoter has been discussed. Using Bioinformatics approaches, we aimed to identify the polymorphisms in upstream regulatory sequences of AHR, which may affect the epigenetic regulation of it through the introduction or removal of CpG dinucleotides that act as possible targets for DNA methylation. The 3000 bp upstream regulatory sequences of AHR, -2700 to +300 relative to the ATG codon, were obtained from NCBI. The CpG-island identified and all 105 SNPs located in it were retrieved from dbSNP. After that, 45 SNPs that cause the introduction or removal of CpGs were identified as candidate EpiPols of AHR. Then, the methylation status of these EpiPols analyzed using Bioinformatics servers, and finally, 13 SNPs were reported as predicted methylation-affecting EpiPols of the human AHR gene.