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    Association of Tourette syndrome and obsessive-compulsive disorder with allergic diseases in children and adolescents: a preliminary study
    (Verduci Publisher, 2014) Yuce, M.; Guner, S. N.; Karabekiroglu, K.; Baykal, S.; Kilic, M.; Sancak, R.; Karabekiroglu, A.
    OBJECTIVES: To investigate the rate of allergic diseases including asthma, allergic rhinitis and eczema in children and adolescents diagnosed with obsessive-compulsive disorder (OCD) (n:26) and/or Tourette syndrome (TS) (n:32) [OCD plus TS, n:13] compared to control subjects (n:35) [total, n:80]. PATIENTS AND METHODS: The symptoms of any allergic disease were assessed using the ISAAC questionnaire form. Allergy diagnoses were made by a pediatric allergy specialist. Skin prick tests were applied, and IgE levels and eosinophil counts were measured. RESULTS: While only one-fifth of the control subjects had allergic diseases, more than half of the children with TS and/or OCD had comorbid allergic diseases. Positive skin prick tests were greater in OCD patients compared to control subjects. There were no significant differences between the groups in terms of eosinophil counts or IgE levels. Among the allergic diseases, while allergic rhinitis was diagnosed at significantly higher rates in TS patients, eczema was significantly higher in OCD patients compared to control subjects. CONCLUSIONS: This preliminary study shows an association between allergic diseases and TS and/or OCD. The results revealing differences in associations between types of allergic disease (rhinitis or eczema) and neuropsychiatric disorder (tic disorder or OCD) need to be investigated in further studies with higher numbers of participants, and immune markers should be examined.
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    Cilostazol-induced relaxation of calf cardiac vein and coronary artery during cooling
    (Comenius Univ, 2013) Nurullahoglu-Atalik, K. E.; Nurullahoglu, Z. U.; Kilic, M.; Aribas, A.
    Objective: At present very little is known about the role of endothelial nitric oxide (NO) in the effects of temperature on vascular reactivity. The aim of the present study is to evaluate the influence of cooling (to 28 degrees C) on the vasodilatation induced by cilostazol(10(-9)-3x10(-4)M) on carbachol (10(-6))-precontracted calf cardiac vein and coronary artery and the role of NO in these effects. Materials and methods: Ring preparations of great cardiac vein and the anterior interventricular branch of left coronary artery were used. Results: Cilostazol produced concentration-dependent relaxation of calf cardiac vein and coronary artery rings precontracted with carbachol. During cooling, the pIC(50) values, but not the maximal responses to cilostazol were significantly lower than at 37 degrees C in both preparations. Cooling to 28 degrees C in the presence of N-G-nitro-L-arginine methyl ester (L-NAME, 10(-4) M) did not modify the effect of temperature both in cardiac vein and coronary artery. These results demonstrate for the first time that cooling-induced changes of cilostazol in calf cardiac vein and coronary artery are independent of NO (Tab. 2, Fig. 3, Ref. 32). Full Text in PDF www.elis.sk.