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Öğe Alterations of the thioredoxin system during subarachnoid hemorrhage-induced cerebral vasospasm(Springer Wien, 2015) Kaya, B.; Erdi, F.; Kilinc, I.; Keskin, F.; Feyzioglu, B.; Esen, H.; Karatas, Y.The exact underlying pathogenic mechanisms and effective preventive or therapeutic interventions for cerebral vasospasm remain obscure. The thioredoxin (Trx) system performs important functions in the central nervous system including neurotrophic and neuroprotective actions. There is no study directly investigating the effects of subarachnoid hemorrhage (SAH) induced cerebral vasospasm on the Trx system in the literature. Sixteen male New Zealand rabbits were randomly divided into two groups of eight rabbits each: a control group and a SAH group. The control group, (n = 8) was a sham surgery group in which SAH was not induced. In the SAH group, (n = 8), the SAH protocol was used to induce cerebral vasospasm. The brain and brainstem were removed and each brainstem was cut coronally into two pieces: an anterior part that contains basilar artery and a dorsal part that contains brainstem tissue. The brainstem tissue thioredoxin-1(Trx1), thioredoxin-2 (Trx2), thioredoxin reductase (TrxR), thioredoxin reductase-1 (TrxR1), thioredoxin-interacting protein (TXNIP) levels were investigated. Total oxidant status (TOS), total antioxidant status (TAS), malondialdehyde levels (MDA) and tumor necrosis factor alpha (TNF-alpha) levels were investigated for determining the oxidative-antioxidative status of the related brain tissues. Basilar artery segments were investigated for cross-sectional area and wall thickness measurements. SAH statistically significantly reduced the tissue levels of Trx1 (p < 0.01) and TrxR (p < 0.01). Trx2 levels were not significantly altered after SAH (p > 0.05). SAH significantly reduced the expression of TrxR1 (p < 0.01) and significantly increased the expression of TXNIP (p < 0.01) when compared with controls. TOS levels and MDA levels significantly increased after SAH (p < 0.01) and TAS levels significantly reduced after SAH (p < 0.01). TNF-alpha levels significantly increased after SAH (p < 0.01). SAH-induced cerebral vasospasm significantly (p < 0.05) increased the wall thickness and reduced the mean cross-sectional area of the basilar artery (p < 0.05). The Trx system seems to be negatively affected by the simultaneously interrelated enzymatic alterations during cerebral vasospasm.Öğe Claudin-5, occludin, zonulin and tricellulin levels of children with attention deficit/hyperactivity disorder(Cambridge Univ Press, 2023) Ferahkaya, H.; Akca, O. F.; Kilinc, I.; Baysal, T.[Abstract Not Availabe]Öğe Claudin-5, occludin, zonulin and tricellulin levels of children with attention deficit/hyperactivity disorder(Cambridge Univ Press, 2023) Ferahkaya, H.; Akca, O. F.; Kilinc, I.; Baysal, T.[Abstract Not Availabe]Öğe Comparison of gel-based proteomic analysis from fresh and FFPE kidney tissue(Wiley-Blackwell, 2016) Kilinc, I.; Findik, S.; Oltulu, P.[Abstract Not Availabe]Öğe The effects of alpha-amanitin on oxidative stress parameters in cardiac tissue(Wiley-Blackwell, 2015) Kilinc, I.; Dundar, Z. D.; Ergin, M.[Abstract Not Availabe]Öğe Effects of mandatory salt iodization on breast milk, urinary iodine concentrations, and thyroid hormones: is iodine deficiency still a continuing problem?(Springer, 2019) Ozberk, D. Isiklar; Kutlu, R.; Kilinc, I.; Kilicaslan, A. O.PurposeTo investigate whether mandatory use of iodized salt in Turkey, since 1999 has sufficient effects on pregnant women and their newborns' urinary iodine concentrations (UIC), maternal and newborns' thyroid function tests and breast milk iodine concentrations (BMIC).MethodsThis cross-sectional analytical-type study was conducted in an obstetrics and gynecology hospital in Konya, Turkey. One hundred and seven pregnant women and their 107 full-term newborns were included into the study. Levels of pregnant women and their newborns' UIC, thyroid-stimulated hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), thyroglobulin (Tg), and BMIC were studied.ResultsOf 107 women with term pregnancy, mean TSH value and hypothyroidism frequency were found as 2.341.33 mIU/L and 18.7%, respectively. Cord blood TSH level was found higher (10 mIU/L) in five newborns. Accordingly, the incidence of transient congenital hypothyroidism was 4.7% (5/107). Tg levels were observed to be higher in 50.5% of newborns and 22.4% of pregnant women. Frequency of iodized salt use in pregnancies was detected as 96.3% in general population, 97.5% in urban, and 92.9% in rural areas. Of pregnancies and newborns, 57.9 and 53.3% were found to have deficient urinary iodine, respectively, and BMIC deficiency was detected as 52.0%. There was a significant positive correlation between pregnant women's UIC, and newborns' UIC and BMIC.Conclusions p id=Par4 Despite the effective struggle with iodine deficiency and salt iodination control program in Konya, we concluded that iodine deficiency still persists as a significant problem in pregnancies.Öğe Effects of Nigella sativa oil on ovarian volume, oxidant systems, XIAP and NF-kB expression in an experimental model of diabetes(Taylor & Francis Ltd, 2019) Seflek, H. N.; Kalkan, S.; Cuce, G.; Kilinc, I.; Sozen, M. E.We investigated the effects of Nigella sativa oil on ovary volume, nuclear factor-kappaB (NF-kappa B), X-linked inhibitor of apoptosis protein (XIAP) expression, and serum malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant status (TAS) and total oxidant status (TOS) levels in diabetic rats. We divided 21 adult female rats into three groups: controls, diabetics and diabetics + N. sativa oil. The diabetics + N. sativa oil group was given 0.2mg/kg/day N. sativa oil 6days/week for 4weeks. NF-kappa B and XIAP expression was assessed in ovarian sections using immunohistochemistry. The right and left ovary volumes were calculated using stereology. We also measured serum MDA, SOD, TAS and TOS levels. We found that N. sativa oil reduced hyperglycemia, but not to control levels. N. sativa oil also exhibited antioxidant properties as demonstrated by reduced serum TOS and MDA levels, and increased SOD and TAS levels compared to controls. We found no significant difference in total ovarian volume, XIAP or NF-kappa B expression among the groups, which may be due to the short study period. Our findings suggest that N. sativa oil may be useful for reducing blood glucose levels and elevated oxidant activity in diabetic patients.Öğe Functional muscle microRNAs in type 2 diabetes mellitus(Wiley-Blackwell, 2014) Kilinc, I.; Ozer, N.; Balci, T.[Abstract Not Availabe]Öğe Method selection for protein extraction from FFPE tissues in the proteomics studies(Wiley-Blackwell, 2015) Kilinc, I.; Kilinc, F.[Abstract Not Availabe]Öğe The role of oxidative stress in the lung toxicity depending on alpha amanita(Wiley-Blackwell, 2015) Kilinc, I.; Dundar, Z. D.; Ergin, M.[Abstract Not Availabe]Öğe Urinary hydroxyproline levels in prediabetic patients(Wiley-Blackwell, 2014) Kilinc, I.; Uysal, S.; Toker, A.; Gokce, H. R.; Akcay, M.[Abstract Not Availabe]
