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Öğe Effects of Smoking on Very-Long Term Mortality after First ST Elevation Myocardial Infarction(Arquivos Brasileiros Cardiologia, 2022) Kiziltunc, Emrullah; Sahin, Yusuf Bozkurt; Topal, Salih; Duzenli, Mehmet Akif; Karakaya, Ekrem; Aygul, Nazif; Topsakal, RamazanBackground: The smoking paradox has been a matter of debate for acute myocardial infarction patients for more than two decades. Although there is huge evidence claiming that is no real paradox, publications supporting better outcomes in post-MI smokers are still being released. Objective: To explore the effect of smoking on very long-term mortality after ST Elevation myocardial infarction (STEMI). Methods: This study included STEMI patients who were diagnosed between the years of 2004-2006 at three tertiary centers. Patients were categorized according to tobacco exposure (Group 1: non-smokers; Group 2: <20 package*years users, Group 3: 20-40 package*years users, Group 4: >40 package*years users). A Cox regression model was used to estimate the relative risks for very long-term mortality. P value <0.05 was considered as statistically significant. Results: There were 313 patients (201 smokers, 112 non-smokers) who were followed-up for a median period of 174 months. Smokers were younger (54 +/- 9 vs. 62 +/- 11, p: <0.001), and the presence of cardiometabolic risk factors were more prevalent in non-smokers. A univariate analysis of the impact of the smoking habit on mortality revealed a better survival curve in Group 2 than in Group 1. However, after adjustment for confounders, it was observed that smokers had a significantly increased risk of death. The relative risk became higher with increased exposure (Group 2 vs. Group 1; HR: 1.141; 95% CI: 0.599 to 2.171, Group 3 vs Group 1; HR: 2.130; 95% CI: 1.236 to 3.670, Group 4 vs Group 1; HR: 2.602; 95% CI: 1.461 to 4.634). Conclusion: Smoking gradually increases the risk of all-cause mortality after STEMI.Öğe Short- and Mid-term Effects of Acute Coronary Syndromes on Smoking Behaviour, Factors Affecting Smoking Status and the Family Physicians' Role After Discharge(Istanbul Training & Research Hospital, 2020) Alsancak, Aybuke Demir; Sengezer, Tijen; Alsancak, Yakup; Dincer, Gokhan; Kiziltunc, Emrullah; Ozkara, AdemIntroduction: Cigarette smoking is one of the most important preventable risk factors for atherosclerotic diseases. This study aims to assess the smoking behaviour after acute coronary syndrome (ACS) and aims to delineate the factors affecting smoking status after discharge. Methods: The Fagerstrom Test for Nicotine Dependence score, the sociodemographic status of patients, types of ACS and applied treatment methods were recorded. The Gensini scoring system was used to evaluate the extent and severity of coronary artery disease. Patients were reached via phone calls in the first, third and sixth month after discharge to assess their smoking status, their reasons for relapse and any recurrences of their diseases. Results: Forty-five percent of patients were treated for ST-elevated myocardial infarction, and 43.2% (n=48) had high or very high levels of dependence. Patients who had early symptoms had a higher rate of quitting smoking (p=0.009). Only 78.4% had thought of quitting smoking after discharge. Seventy-four (66.6%) patients underwent catheter-based interventions. The rates of relapse were 20.8% (n=15), 42.6% (n=32) and 53.9% (n=41) at the end of the first, third and sixth month after discharge, respectively. Gensini scores seemed to be higher among patients who had quit smoking (p<0.05). Patients who have received medical treatment had a higher rate of smoking than before the end of six months (p<0.05). Only 28.8% (n=32) of patients stated that they had received information about smoking cessation from their family physician and 3.6% (n=4) of patients have applied to a smoking cessation unit. Conclusion: Smoking cessation rates of patients who have suffered an ACS were low and rates of cigarette consumption in the following periods tended to increase. Family physicians should take a more active role in this topic in Turkey.Öğe Vitamin D Deficiency and Its Correlation with Coronary Artery Ectasia(Gazi Univ, Fac Med, 2020) Sezenoz, Burak; Alsancak, Yakup; Kiziltunc, Emrullah; Ozkan, Selcuk; Cengel, AtiyeObjectives: Vitamin D plays a pivotal role in cardiovascular system and its deficiency is related to various of cardiovascular disorders. We investigated the association between serum vitamin D level and coronary artery ectasia formation. Methods: Our study included 45 patients with coronary artery ectasia and 55 patients with normal coronary artery. Vitamin D and parathyroid hormone levels were obtained before coronary angiography. Results: Baseline characteristic features were similar between groups. The Vitamin D levels and serum calcium levels were significantly lower in the coronary artery ectasia group compare to control group (respectively; 15.6 ng/ml vs. 12.0 ng/ml; p=0.002 and 9,52 vs. 9.0; p<0.001). PTH level of CEA patients were higher than the control group (44.0 pg/ml vs. 29.5 pg/ml; p=0.018). Conclusion: Our results showed a significant inverse correlation between Vitamin D deficiency and coronary artery ectasia.Öğe Vitamin D Deficiency and Its Correlation with Coronary Artery Ectasia(Gazi Univ, Fac Med, 2020) Sezenoz, Burak; Alsancak, Yakup; Kiziltunc, Emrullah; Ozkan, Selcuk; Cengel, AtiyeObjectives: Vitamin D plays a pivotal role in cardiovascular system and its deficiency is related to various of cardiovascular disorders. We investigated the association between serum vitamin D level and coronary artery ectasia formation. Methods: Our study included 45 patients with coronary artery ectasia and 55 patients with normal coronary artery. Vitamin D and parathyroid hormone levels were obtained before coronary angiography. Results: Baseline characteristic features were similar between groups. The Vitamin D levels and serum calcium levels were significantly lower in the coronary artery ectasia group compare to control group (respectively; 15.6 ng/ml vs. 12.0 ng/ml; p=0.002 and 9,52 vs. 9.0; p<0.001). PTH level of CEA patients were higher than the control group (44.0 pg/ml vs. 29.5 pg/ml; p=0.018). Conclusion: Our results showed a significant inverse correlation between Vitamin D deficiency and coronary artery ectasia.