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Öğe Comparison of housekeeping genes for qPCR analysis in rat hippocampus: chronic depression model(Wiley, 2019) Kurar, E.; Eroglu, C.; FarukUguz; Ak, Mehmet; Koca, R. O.; Solak, H.; Koc, A.[Abstract Not Availabe]Öğe Effects of Sertraline in Healthy and Damaged Rat Aorta(Wiley, 2017) Koc, A.; Gormus, Z. I. Solak; Solak, H.; Koca, R. Ozen; Sahin, Z.; Gormus, N.; Kutlu, S.[Abstract Not Availabe]Öğe Inhibitory effects of acetylsalicylic acid on exocrine pancreatic carcinogenesis(Taylor & Francis Ltd, 2013) Yildiz, H.; Oztas, H.; Yildiz, D.; Koc, A.; Kalipci, E.We investigated short (6 months) and long (12 months) term inhibitory effects of low (200 ppm) and high (400 ppm) dosages of acetylsalicylic acid (aspirin) on exocrine pancreatic carcinogenesis. It is known that exocrine pancreatic carcinogenesis can be detected by the presence of atypical acinar cell foci (AACF) in pancreas. We investigated possible inhibitory effects of acetylsalicylic acid in an azaserine-treated rat model. AACF were produced in rats by injection with azaserine according to previous studies. Our findings showed that the number, volume and diameter of pancreatic AACF were reduced after acetylsalicylic acid application. These observations suggest that acetylsalicylic acid may exert a protective effect against neoplastic development of pancreatic acinar cells in azaserine injected rats. Our findings corroborate reports in the literature concerning the effects of aspirin in reducing neoplastic development.Öğe Investigation of Effects of Two Chronic Stress Protocols on Depression-Like Behaviors and Brain Mineral Levels in Female Rats: an Evaluation of 7-Day Immobilization Stress(Springernature, 2021) Sahin, Z.; Ozkurkculer, A.; Kalkan, O. F.; Ozkaya, A.; Koc, A.; Koca, R. Ozen; Solak, H.We aimed to investigate the effects of two different chronic immobilization stress protocols on depression-related behaviors and brain mineral levels. Adult female Wistar albino rats were divided into 3 groups as follows (n = 10/group): control, immobilization stress-1 (45 min daily for 7 days), and immobilization stress-2 (45 min twice a day for 7 day). Stress-related behavior was evaluated by means of the forced swimming test (FST) and open field test (OFT). Minerals were analyzed using an inductively coupled plasma mass spectrometer. In the FST, swimming and immobility were significantly lower in the immobilization stress-1 and immobilization stress-2 groups. The climbing duration of the immobilization stress-2 group was higher than the control group. In the OFT, percentage of time spent in the central area was significantly lower in the immobilization stress-1 and immobilization stress-2 groups. Values of latency to center area, rearing, and grooming did not significantly differ between groups. In the immobilization stress-1 group, zinc was lower, and iron, copper, and manganese were higher than the control group. In the immobilization stress-2 group, copper and manganese were higher, and phosphate was lower than the control group. Our results showed that depression-related behaviors were more dominant in the immobilization stress-1 group. A decrease in the brain zinc level was valid only for the immobilization stress-1 group. These results point to the role of low brain zinc levels in the pathophysiology of depression.Öğe Possible Effects of Sertraline on Human Heart Muscle Contractility: An in vitro experimental study(Wiley, 2017) Solak, H.; Gormus, Z. I. Solak; Koca, R. Ozen; Koc, A.; Karaibrahimoglu, A.; Kutlu, S.; Gormus, N.[Abstract Not Availabe]
