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Öğe Chronic immobilization stress induces anxiety-related behaviors and affects brain essential minerals in male rats(Hogrefe Ag-Hogrefe Ag Suisse, 2022) Sahin, Zafer; Ozkurkculer, Alpaslan; Kalkan, Omer Faruk; Ozkaya, Ahmet; Koc, Aynur; Koca, Raviye Ozen; Solak, HaticeAlterations of essential elements in the brain are associated with the pathophysiology of many neuropsychiatric disorders. It is known that chronic/overwhelming stress may cause some anxiety and/or depression. We aimed to investigate the effects of two different chronic immobilization stress protocols on anxiety-related behaviors and brain minerals. Adult male Wistar rats were divided into 3 groups as follows (n = 10/group): control, immobilization stress-1 (45 minutes daily for 7-day) and immobilization stress-2 (45 minutes twice a day for 7-day). Stress-related behaviors were evaluated by open field test and forced swimming test. In the immobilization stress-1 and immobilization stress-2 groups, percentage of time spent in the central area (6.38 +/- 0.41% and 6.28 +/- 1.03% respectively, p < 0.05) and rearing frequency (2.75 +/- 0.41 and 3.85 +/- 0.46, p < 0.01 and p < 0.05, respectively) were lower, latency to center area (49.11 +/- 5.87 s and 44.92 +/- 8.04 s, p < 0.01 and p < 0.01, respectively), were higher than the control group (8.65 +/- 0.49%, 5.37 +/- 0.44 and 15.3 +/- 3.32 s, respectively). In the immobilization stress-1 group, zinc (12.65 +/- 0.1 ppm, p < 0.001), magnesium (170.4 +/- 1.7 ppm, p < 0.005) and phosphate (2.76 +/- 0.1 ppm, p < 0.05) levels were lower than the control group (13.87 +/- 0.16 ppm, 179.31 +/- 1.87 ppm and 3.11 +/- 0.06 ppm, respectively). In the immobilization stress-2 group, magnesium (171.56 +/- 1.87 ppm, p < 0.05), phosphate (2.44 +/- 0.07 ppm, p < 0.001) levels were lower, and manganese (373.68 +/- 5.76 ppb, p < 0.001) and copper (2.79 +/- 0.15 ppm, p < 0.05) levels were higher than the control group (179.31 +/- 1.87 ppm, 3.11 +/- 0.06 ppm, 327.25 +/- 8.35 ppb and 2.45 +/- 0.05 ppm, respectively). Our results indicated that 7-day chronic immobilization stress increased anxiety-related behaviors in both stress groups. Zinc, magnesium, phosphate, copper and manganese levels were affected in the brain.Öğe Comparison of Fluoxetine and Sertraline in Treatment of Postoperative Depression(Wiley, 2018) Gormus, Z. Isik Solak; Gormus, Niyazi; Solak, Hatice; Koca, Raviye Ozen; Koc, Aynur; Taki, Fatma Nur; Kutlu, Selim[Abstract Not Availabe]Öğe Does Phosphodiesterase Inhibiting Agent-Milrinone Prevent Negative Inotropic Effects of Sertraline on Postoperative Human Heart Muscle Contractility? An In Vitro Experimental Study(Wiley, 2017) Gormus, Zulfikare Isik Solak; Koca, Raviye Ozen; Koc, Aynur; Solak, Hatice; Ozdemir, Ayse; Sahin, Zafer; Kutlu, Selim[Abstract Not Availabe]Öğe Effect of 3?-4?-dihydroxyflavonol on lipid per oxidation in experimental renal ischemia-reperfusion in rats(Univ Karachi, 2019) Koc, Aynur; Ergene, Neyhan; Baltaci, Abdulkerim Kasim; Mogulkoc, RasimThis study aimed to examine the affects of 3'-4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental renal ischemia-reperfusion. The research was conducted on Wistar-albino type male rat. The experimental groups were formed as 1.Control; 2.Sham; 3.Ischemia; 4.Ischemia+reperfusion; 5.DiOHF+Ischemia; 6.Ischemia+ DiOHF + reperfusion. The highest tissue glutathione levels were found in groups 5 and 6. Groups 1 and 2, which were control and sham groups respectively, had the lowest tissue GSH values. Ischemia group was found to have the highest tissue malondialdehyde (MDA) level. Tissue MDA levels in group 4 were lower than those in group 3, however, higher than the levels in all other groups. Erythrocyte GSH levels in groups 5 and 6 were higher than the levels in all other groups. Group 4 has highest plasma MDA values. Plasma MDA levels in group 3 were lower than the levels in Group 4, but higher than those in other groups. The results of the study indicate that intraperitoneal DiOHF administration inhibits lipid per oxidation that intensifies in the case of renal ischemia-reperfusion injury in rats.Öğe Effect of Intravenous Glucose Administration on Catecholamine Concentrations in Hypothalamic Ventromedial Nucleus in Rats: A Microdialysis Study(Wiley-Blackwell, 2016) Solak, Hatice; Koca, Raviye Ozen; Gormus, Z. Isik Solak; Sahin, Zafer; Koc, Aynur; Karaibrahimoglu, Adnan; Kutlu, Selim[Abstract Not Availabe]Öğe Effect of Pregnancy and Lactation Period on Depression Like Behaviour in Depressive Rats(Karger, 2018) Solak, Hatice; Koca, Raviye Ozen; Koc, Aynur; Sahin, Zafer; Uguz, Faruk; Ak, Mehmet; Kurar, Ercan[Abstract Not Availabe]Öğe Effect of RFRP-3 on Anxiety-like Behaviour and Hippocampal Neurogenesis in Rats(Wiley-Blackwell, 2016) Boyukcam, Yasemin; Sahin, Zafer; Koc, Aynur; Eroglu, Canan; Gormus, Isik Solak; Kurar, Ercan; Kutlu, Selim[Abstract Not Availabe]Öğe Effects of Resveratrol on In Vitro Stomach Smooth Muscle Contraction in Rats with Hepatocellular Carcinoma(Wiley, 2017) Koc, Aynur; Cetinkaya, Seda; Solak, Hatice; Gormus, Zulfikare Isik Solak; Kutlu, Selim; Ozgorgulu, Aydan[Abstract Not Availabe]Öğe Evaluation of Effects of Three Distinct Stress Protocols on Depression and/or Anxiety-like Behaviors in Female Rats(Wiley, 2017) Sahin, Zafer; Koc, Aynur; Koca, Raviye Ozen; Solak, Hatice; Ozkurkculer, Alpaslan; Gormus, Zulfikare Isik Solak; Kutlu, Selim[Abstract Not Availabe]Öğe Hypothalamic Expressions of Apelin, Apelin Receptor and Neuritine in the First Generation Rat Pups: A Maternal Depression Model(Karger, 2021) Kurar, Ercan; Gunes, Canan Eroglu; Koca, Raviye Ozen; Solak, Hatice; Koc, Aynur; Sahin, Zafer; Cuce, Gokhan[Abstract Not Availabe]Öğe Investigation of Effect of Intravenous Glucose Administration on Noradrenaline Levels in Lateral Hypothalamic Area by using Microdialysis Method in Rat(Wiley-Blackwell, 2015) Solak, Hatice; Koca, Raviye Ozen; Gormus, Zulfikare Isik Solak; Sahin, Zafer; Koc, Aynur; Kutlu, Selim[Abstract Not Availabe]Öğe Investigation of Effects of Dimethyl Sulphoxide on Smooth Muscle Contractions in Rat Tissues in Isolated Organ Baths(Wiley, 2017) Solak, Hatice; Taki, Fatma Nur; Koc, Aynur; Koca, Raviye Ozen; Gormus, Z. Isik Solak; Sahin, Zafer; Kutlu, Selim[Abstract Not Availabe]Öğe Long Period Housing in Metabolic Cage Causes Unfavorable Effects on Psychophysiological Parameters in Adult Male Rats(Wiley, 2017) Sahin, Zafer; Solak, Hatice; Koc, Aynur; Koca, Raviye Ozen; Ozkurkculer, Alparslan; Candan, Pinar; Gormus, Z. Isik Solak[Abstract Not Availabe]Öğe Long-term metabolic cage housing increases anxiety/depression-related behaviours in adult male rats(Taylor & Francis Ltd, 2019) Sahin, Zafer; Solak, Hatice; Koc, Aynur; Koca, Raviye Ozen; Ozkurkculer, Alpaslan; Cakan, Pinar; Gormus, Zulfikare Isik SolakThere are several reports on unfavourable effects of metabolic cage housing on animal welfare mainly due to the characteristic structures of these cages such as single housing and grid flooring. This study was aimed to compare the effects of long-term metabolic cage housing and conventional housing (normal grouped housing in standard cages) on the anxiety/depression-like behaviours in male rats. Anxiety/depression-related behaviours were evaluated by use of forced swimming test and open field test. Swimming and climbing were significantly lower and immobility duration higher in the metabolic cage group. In the open field test, total distance, mean velocity, time spent in the central area, zone transition, grooming, and rearing scores were significantly lower in the metabolic cage. Moreover, serum corticosterone level was higher in the metabolic cage group. The results of the study indicate that long-term metabolic cage housing may cause an increase in the anxiety- and depression-related behaviours in male rats.Öğe Which Antidepressant is Safer for a Postoperative Cardiac Patient?(Wiley, 2018) Gormus, Niyazi; Gormus, Z. Isik Solak; Koc, Aynur; Solak, Hatice; Koca, Raviye Ozen; Taki, Fatma Nur; Ozdemir, Ayse[Abstract Not Availabe]
