Yazar "Koc, Tugba" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Chemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in rats
    (Elsevier Ireland Ltd, 2015) Cuce, Gokhan; Cetinkaya, Seda; Koc, Tugba; Esen, Haci Hasan; Limandal, Cisem; Balci, Tevfik; Kalkan, Serpil
    Cyclophosphamide (CP) has a range of adverse effects on liver tissue in humans and animals. Administering an antioxidant with CP might reduce such side effects. Therefore, we examined the role of vitamin E in CP-induced liver toxicity in rats. Male Wistar albino rats were divided into four groups, each of seven rats: control, CP only, CP + vitamin E, and vitamin E only groups. The rats were administered treatments intraperitoneally for 7 days. Then the serum malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate transaminase (AST), and lactate dehydrogenase (LDH) levels were determined while the livers were removed, tissue was prepared using routine histological procedures, sections were stained using hematoxylin and eosin, and the terminal deoxynucleotidyl transferase-mediated nick end-labeling (TUNEL) method was applied. Histopathologically, CP caused hydropic degeneration, necrosis, pleomorphism, and mitotic activity. The number of TUNEL-positive cells and the MDA and ALT levels were significantly higher in the CP group. The antioxidant effects of vitamin E significantly decreased the number of TUNEL-positive cells and the ALT and MDA levels, and normalized the liver histopathology. CP induces apoptosis, has toxic effects on liver tissue, and changes the histological structure. The administration of vitamin E prevented the liver tissue damage caused by CP. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
  • Küçük Resim Yok
    Öğe
    Vitamin E partially ameliorates cyclophosphamide-induced nephrotoxicity in rats
    (Mattioli 1885, 2016) Cuce, Gokhan; Esen, Haci Hasan; Koc, Tugba; Canbaz, Halime Tuba; Limandal, Cisem; Kalkan, Serpil; Gurbilek, Mehmet
    Purpose: Cyclophosphamide (CP) is a widely used anti chemotherapeutic drug, which causes nephrotoxicity due to its toxic metabolites. This study was carried out to assess the effects of vitamin E on cyclophosphamide induced renal toxicity in rats. Model: Twenty-eight Wistar albino rats were assigned to four groups, which were given 20 mg/kg CP, 20 mg/kg CP + 100 mg/kg vitamin E, 100 mg/kg vitamin E, or 20 mg/kg isotonic sodium chloride solution intraperitoneally each day for 7 days. Effects were assessed by histology of the kidney, TUNEL assay and measurement of serum uric acid and creatinine. Results: Cyclophosphamide significantly increased glomerular inflammation, edema, congestion and tubular degeneration, TUNEL positive cells, while addition of vitamin E significantly decreased glomerular inflammation, edema and TUNEL positive cells. Cyclophosphamide did not affect urea and creatinine levels, which may due to the absence of renal necrosis. Conclusion: Vitamin E application appears to partially ameliorate Cyclophosphamide induced renal toxicity.