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    The Effects of Topical Insulin Application on Wound Healing
    (Modestum Ltd, 2015) Kargin, Suleyman; Tastekin, Didem; Kilic, Kemal; Cezik, Azamet; Cakir, Murat; Kucukkartallar, Tevfik; Kokbudak, Naile
    The process of wound healing is a dynamic event during which the stages of fibroplasia, angiogenesis, and re-epithelization perfectly take place. The aim of this study is to compare the effects of wound irrigation by normal saline and topical insulin application, which we frequently use in clinical practice, on wound healing. The study covers a total of 20 male rats - 10 for the insulin group and 10 for the control group. The first group received topical insulin application while the second group had irrigation by normal saline. The macroscopic outlook, collagen production, and wound contraction rates in the animals wounds were checked at the end of day 20. The rate of wound closing was found to be higher in the topical insulin group than the NS group at all times. Further, the period of complete wound closing was shorter than the insulin group. Histopathological analysis revealed that the ulceration and inflammation were localized in the subepithelial field in the skin cross-sections of the insulin group and that there was a significant increase in collagen bundles. Thus, we think that insulin can be an alternative to normal saline application specifically in chronic wounds related to diabetes and post-op wound care.
  • Küçük Resim Yok
    Öğe
    The Effects of Topical Insulin Application on Wound Healing
    (Modestum Ltd, 2015) Kargin, Suleyman; Tastekin, Didem; Kilic, Kemal; Cezik, Azamet; Cakir, Murat; Kucukkartallar, Tevfik; Kokbudak, Naile
    The process of wound healing is a dynamic event during which the stages of fibroplasia, angiogenesis, and re-epithelization perfectly take place. The aim of this study is to compare the effects of wound irrigation by normal saline and topical insulin application, which we frequently use in clinical practice, on wound healing. The study covers a total of 20 male rats - 10 for the insulin group and 10 for the control group. The first group received topical insulin application while the second group had irrigation by normal saline. The macroscopic outlook, collagen production, and wound contraction rates in the animals wounds were checked at the end of day 20. The rate of wound closing was found to be higher in the topical insulin group than the NS group at all times. Further, the period of complete wound closing was shorter than the insulin group. Histopathological analysis revealed that the ulceration and inflammation were localized in the subepithelial field in the skin cross-sections of the insulin group and that there was a significant increase in collagen bundles. Thus, we think that insulin can be an alternative to normal saline application specifically in chronic wounds related to diabetes and post-op wound care.
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    Measurement of Epidermis, Dermis, and Total Skin Thicknesses from Six Different Body Regions with a new Ethical Histometric Technique
    (Wolters Kluwer Medknow Publications, 2018) Oltulu, Pembe; Ince, Bilsev; Kokbudak, Naile; Findik, Sidika; Kilinc, Fahriye
    Introduction: Although it is important to know the normal values of dermis, epidermis, or total skin thicknesses (ST) for some drugs and vaccine research, skin-related clinical investigations, and skin transfer operations used in plastic surgery, it would not be ethical to take new biopsies from healthy volunteers to measure their ST. This study aims to describe a new ethical histometric technique for the measurement of skin layers and to determine the mean ST of some major body regions in the people living in our region. Materials and Methods: A total of 180 skin samples from six major body regions of 90 males and 90 females were enrolled in the study. The measurements were performed histometrically from appropriate skin samples obtained from the pathology archive. The samples were classified according to the six different parts of the body (scalp, abdomen, back, dorsum of foot, dorsum of hand, and the breast). Results: The mean epidermal thickness ranged from 76.9 +/- 26.2 to 267.4 +/- 120.6 mu m. The thickest epidermis was found in the dorsum of foot in women (267.4 +/- 120.6 mu m) while the thinnest was found in the breast in women (76.9 +/- 26.2 mu m). The mean dermal thickness ranged from 2115 +/- 946.4 to 5888 +/- 2422.3 mu m. The thickest dermis was found in the breast in men (5888 +/- 2422.3 mu m), while the thinnest dermis was found in the dorsum of hand in women (2115 +/- 946.4 mu m). Conclusions: Human ST varies according to ethnic origin. It was determined that the dermis and epidermis of Anatolian people are thicker than that of the previously reported other ethnic groups. The skin pathology archive can be used to create maps of the body's skin structure.
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    Pilomyxoid astrocytoma showing malignant transformation in adult male
    (Modestum Ltd, 2017) Findik, Siddika; Esen, H. Hasan; Erdi, M. Fatih; Oltulu, Pembe; Kokbudak, Naile; Gungor, Salim
    Pilomyxoid astrocytomas are type of tumors rarely seen in the central nervous system as a variant of pilocytic astrocytoma. They are often localized in hypothalamic-chiasmatic area and seen in early childhood. They exhibit different histological characteristics and more aggressive behaviors compared to pilocytic astrocytomas. Although cases with malignant transformation were reported in pilocytic astrocytomas, no pilomyxoid astrocytoma patients was reported with malignant transformation. We have presented a pilomyxoid astrocytoma patient, since it is rarely seen in adulthood and shows malignant transformation histopathologically.
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    Relationship of preoperative neutrophil lymphocyte ratio with prognosis in gastrointestinal stromal tumors
    (Turkish Surgical Assoc, 2015) Kargin, Suleyman; Cakir, Murat; Gundes, Ebubekir; Yavuz, Yusuf; Esen, Haci Hasan; Iyisoy, M. Sinan; Kokbudak, Naile
    Objective: Gastrointestinal stromal tumors are believed to play a role in immunosuppression with their local effect. In some cancers with associated inflammation, an increased pretreatment neutrophil lymphocyte ratio is considered as an indicator of poor prognosis. The aim of our study was to assess the relationship of increased blood neutrophil lymphocyte ratio with disease prognosis in patients with gastrointestinal stromal tumors. Material and Methods: The data of 78 patients who underwent surgery with the diagnosis of primary gastrointestinal stromal tumor in our clinic were evaluated retrospectively. The preoperative neutrophil lymphocyte ratio in the peripheral blood was determined. The neutrophil lymphocyte ratio and its relationship with tumor risk and prognosis were compared. The data were evaluated by Pearson's correlation analysis and the Welch ANOVA test. Results: The preoperative neutrophil lymphocyte ratio was significantly increased in the high-risk groups (p<0.05). An increased preoperative neutrophil lymphocyte ratio was associated with shorter survival (r=-0.32, p=0.009). In addition, an increase in the neutrophil lymphocyte ratio was associated with an increase in the mitotic activity of the tumor (r=-0.364, p=0.025). Conclusion: The preoperative neutrophil lymphocyte ratio in gastrointestinal stromal tumors can be used as an indicator of high-risk tumors and poor prognosis.