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    The Effect of Soluble TREM-1 in Idiopathic Granulomatous Mastitis
    (Taylor & Francis Inc, 2022) Ates, Dervis; Doner, Hulusi Cem; Kurban, Sevil; Koksal, Hande
    Background and objectives: The aim of this study is to investigate the effect of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in idiopathic granulomatous mastitis (IGM). Methods: This case-control study was conducted in Saglik Bilimleri and Necmettin Erbakan Universities. Sixty patients with IGM diagnosis (Group P) and 25 healthy females as control group (Group C) were included. Group P was divided into two subgroups according to the activity of disease: patients with active lesion (Group P-A), and patients without any symptoms, in remission (Group P-R). The ELISA method was used to measure sTREM-1 level. Results: Group P's sTREM-1 were higher than Group C (p < .0001). The difference between sTREM-1 levels of Groups P-A, P-R and C was significant statistically (p < .0001). Group P-A's sTREM-1 levels were higher than Group C (p < .0001). Also, sTREM-1 levels of Group P-R were higher than Group C (p = .006). When sTREM-1 levels of patients receiving steroid therapy and did not in Group P-R were analyzed, the sTREM-1 levels of the patients not receiving steroid treatment were found to be statistically higher than Group C (p = .002). Although the sTREM-1 levels of the patients who did not receive steroid therapy were higher than those who received steroid therapy, the difference was not statistically significant (p > .05). Conclusion: We concluded that the detected high sTREM-1 levels contributed to inflammation in IGM. In particular, blockade of TREM may be a promising treatment option in resistant or multiple recurrent patients.
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    Is the increase in the number of pilonidal sinus surgery normal?
    (Aves, 2010) Karahan, Omer; Eryilmaz, Mehmet Ali; Torun, Veli; Sevinc, Baris; Koksal, Hande; Aksoy, Faruk; Ay, Serdan
    Purpose: We have noticed the increase in pilonidal sinus operations (PSO) and performed this study to determine the extent of this change and if there is a difference between the number of pilonidal sinus surgery and outpatient and inpatient numbers. Material and Method: We scanned PSO, which was performed in three hospitals [medical faculty hospital (MFH), education and research hospital (ERH) and state hospital (SH)] in the same city, in the last 10 years between 1999 and 2008. We have determined the yearly distribution of cases, total number of operations performed, number of general surgery operations (GSO) at the same period and changes in staff of general surgery clinics. We reviewed the number of outpatients, inpatients and the middle group surgical procedures containing PSO as well, performed at the whole city and the country in the last 10 years. Results: The number of PSO was 234 and the number of GSO was 7.728 at MFHs in the first 5 years. These numbers were 259 and 10.384 in the second period, respectively. The increase was 11% for PSO and 72% for GSO. The increase in PSO was lower than GSO. In ERH there were 506 PSOs in the first 5 years and 760 PSOs in the second 5 years. The number of GSO had increased from 11.563 to 11.452 in the second 5 years. There was a 1% decrease in the number of GSOs, whereas the number of PSOs increased by 50% (p<0.001). The number of PSOs performed in SHs increased from 353 to 1.224, by 247%. Also, the number of GSO increased from 10.215 to 15.595, by 53%. The increase in the number of PSOs in two hospitals (ERH and SH) was statistically significant (p<0.001). The number of PSOs was 246 in 2005 and it became 1.341 in 2008, with an increase of 439% at the whole city. Considering Turkey, the number of PSOs performed was 12.415 in 2005 and it increased to 54.633 (340%) in 2008. Conclusion: There is a rapid increase in the number of PSOs performed at the state hospitals in Konya and all around Turkey. Absolute reasons for this increase should be investigated and preventive measures should be taken.