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    Evaluation of diagnostic performance of haematological parameters in Behcet's disease
    (Wiley-Hindawi, 2021) Tezcan, Dilek; Korez, Muslu Kazim; Gulcemal, Semral; Hakbilen, Selda; Akdag, Turan; Yilmaz, Sema
    Objective Behcet's Disease (BD) is a polygenic and chronic autoinflammatory multisystemic vasculitis disease characterised by mucocutaneous, musculoskeletal, neurological, gastrointestinal and ophthalmologic lesions. There has been no specific test or serum marker to measure and determine the diagnosis and severity of BD. Purpose The study aimed to investigate the diagnostic performance of haematological parameters as MLR (monocyte to lymphocyte ratio), NLR (neutrophil to lymphocyte ratio), PLR (platelet to lymphocyte ratio), MPV (mean platelet volume), MPVPR (mean platelet volume to platelet ratio), LMR (lymphocyte to monocyte ratio), LPM (lymphocyte and platelet multiplication), WLP (lymphocyte and leukocyte multiplication), RDW (red blood cell distribution width) and PCT (plateletcrit) in BD and compare these with disease activity and clinical findings. Methods A total of 266 participants (49 healthy control and 217 BD patients) were recruited from the rheumatology department in a single-centre as a case-control study. The laboratory data were obtained from the electronic registration database. BD Activity scores (BDCAF/Behcet's Disease Current Activity Form) were calculated. Laboratory findings of BD patients and healthy controls were compared and evaluated. Results RDW, Platelet, PCT, NLR and PLR values were significantly higher in patient group than in the healthy controls. However, haemoglobin, MPVPR and LMR were significantly lower in the patient group which compared with the healthy controls. LPM in BD with genital ulcers, WLP in BD with genital ulcers and arthritis, MPR in BD with uveitis, RDW in BD with thrombosis and neuro-Behcet's disease (NBD), PLR in NBD were observed to be higher. However, LMR in NBD and MPV in BD with thrombosis were lower than those without. There was a positive correlation between BDCAF score and RDW, and NLR. Conclusion Haemoglobin, RDW, Platelet, PCT, NLR, LMR, PLR and MPVPR were statistically significant predictors for BD. RDW, PCT and NLR are the most valuable predictors for BD.
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    Evaluation of serum interleukin-6 (IL-6), IL-13, and IL-17 levels and computed tomography finding in interstitial lung disease associated with connective tissue disease patients
    (Springer London Ltd, 2021) Tezcan, Dilek; Sivrikaya, Abdullah; Ergun, Dilek; Ozer, Halil; Eryavuz Onmaz, Duygu; Korez, Muslu Kazim; Akdag, Turan
    Objective: Interstitial lung disease (ILD) is one of the most severe complications which is associated with connective tissue disease (CTD) and causes to morbidity and mortality. So, we aimed to determine serum levels of interleukin-6 (IL-6), IL-13, and IL-17, to investigate whether these cytokines are related to CTD-ILD, and to find their possible contribution to determining the prognosis of the disease. Methods: A total of 150 participants, 80 patients diagnosed with CTD-ILD (mean age, 58.21 +/- 12.36) and 70 healthy controls (mean age, 57.07 +/- 9.60) were recruited from the rheumatology department between January 2016 and June 2019 in the study. High-resolution computed tomography (HRCT) findings were scored as similarly to previous studies. Serum IL-6, IL 13, and IL-17 levels were measured by ELISA test kits. Results: The levels of IL-6, IL-13, and IL-17 in CTD patients were significantly higher than the healthy individuals (p < 001), but the HRCT score's relation were not determined. IL-6 was associated with disease duration and disease activity scores of DAS28, ESDAII, and dSSc. There was a significant relation between dSSc, HCRT fibrosis, and total score. CRP, hemoglobin, and platelets were associated with the HRCT inflammation pattern. Conclusion: At the study, it has been observed that serum IL-13, IL-6 and IL-17 levels are increased in patients with CTD-ILD. Besides, IL-6 was associated with disease activity scores of DAS28, ESDAII, and dSSc. Also, HRCT fibrosis score is associated with dSSc. Further and comprehensive studies are needed to understand better the complex intersection of lung disease with systemic autoimmunity.
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    SARC-F is a Weaker Predictor Compared to Muscle Strength and a Stronger Predictor Compared to Muscle Mass for Mortality and Hospitalization in Hemodialysis Patients
    (Aves, 2022) Yavuz, Yasemin Coskun; Biyik, Zeynep; Korez, Muslu Kazim; Abusoglu, Sedat; Ahmadli, Nicat; Eryavuz, Duygu; Batur, Elif
    Objective: It is known that muscle strength and muscle mass decrease in hemodialysis patients. We aimed to compare the effect of SARC-F (strength, assistance with walking, rising from a chair, climbing stairs, and falls) questionnaire with that of handgrip strength and skeletal muscle mass/body mass index on 1-year mortality and hospitalization in hemodialysis patients. Methods: SARC-F test was filled for 67 hemodialysis patients, muscle strength was evaluated with handgrip strength, muscle mass was evaluated by performing bioimpedance analysis, and skeletal muscle mass/body mass index was evaluated by using the formula. Results: The end of 1 year revealed that 12 of 67 patients (17.9%) died. Of the patients, 38 (56.7%) were hospitalized. The number of hospitalizations was in the range of 0-9. The length of hospitalization varied between 2 and 77 days. The patients with low handgrip strength had a 9.86 times higher mortality risk (odds ratio = 9.862, 95% CI = 1.190-81.707, P =.034) and had a 5.27 times higher risk of hospitalization (odds ratio = 5.273, 95% CI = 1.828-15.207, P =.002). The patients who had lower SARC-F had a 3.88 times higher risk of hospitalization (odds ratio = 3.882, 95% CI = 1.340-11.252, P =.012). A positive statistically significant correlation was found between the patients' hospitalization periods and SARC-F scores (Spearman's rho = 0.329, P =.007), and a negative statistically significant correlation was found between the patients' hospitalization periods and handgrip strength scores. The duration of hospitalization was found to be significantly longer in the patients who had low handgrip strength (19.38 +/- 22.25). Conclusion: SARC-F appears to be a weaker parameter than handgrip strength and a stronger parameter than skeletal muscle mass/body mass index on hospitalization and mortality.