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Öğe Abnormal quantitative pupillary light responses following COVID-19(Springer, 2022) Bitirgen, Gulfidan; Korkmaz, Celalettin; Zamani, Adil; Iyisoy, Mehmet Sinan; Kerimoglu, Hurkan; Malik, Rayaz A.Purpose To characterize alterations in pupillary light reflex responses in subjects following coronavirus disease 2019 (COVID-19), especially those with long-COVID. Methods Thirty-five subjects with previous COVID-19 and 30 healthy control participants were enrolled in this cross-sectional comparative study. An infrared dynamic pupillometry system (MonPack One; Metrovision, France) was used to quantify pupillary light responses. The National Institute for Health and Care Excellence (NICE) long-COVID questionnaire was used to identify persisting symptoms at least 4 weeks after acute COVID-19. Results The median time after the diagnosis of acute COVID-19 was 4.0 (2.0-5.0) months. There was an increase in the latency of pupil contraction (P = 0.001) and a reduction in the duration of pupil contraction (P = 0.039) in post-COVID-19 subjects compared to healthy controls. No significant differences were observed in the initial pupil diameter, amplitude and velocity of pupil contraction or latency, velocity and duration of pupil dilation. Long-COVID was present in 25/35 (71%) subjects and their duration of pupil contraction was reduced compared to subjects without long-COVID (P = 0.009). The NICE long-COVID questionnaire total score (rho = - 0.507; P = 0.002) and neurological score (rho = - 0.412; P = 0.014) correlated with the duration of pupil contraction and the total score correlated with the latency of dilation (rho = - 0.352; P = 0.038). Conclusion Dynamic pupillometry reveals significant alterations in contractile pupillary light responses, indicative of parasympathetic dysfunction after COVID-19.Öğe Antioxidant effects of bisphosphonates in smoking- induced lung injury in rat model(European Respiratory Soc Journals Ltd, 2015) Korkmaz, Celalettin; Yavsan, Durdu Mehmet; Demirbas, Soner; Oltulu, Pembe; Kilinc, Ibrahim; Uyar, Mehmet; Gok, Mehmet[Abstract Not Availabe]Öğe Apoptosis-induced T-cell lymphopenia is related to COVID-19 severity(Wiley, 2021) Cizmecioglu, Ahmet; Cizmecioglu, Hilal Akay; Goktepe, Mevlut Hakan; Emsen, Ayca; Korkmaz, Celalettin; Tasbent, Fatma Esenkaya; Consultant, Fatma ColkesenIncreased levels of acute-phase reactants and lymphopenia are predictors of disease severity in coronavirus disease 2019 (COVID-19). This study aimed to investigate the role of apoptosis in the etiology of lymphopenia in patients with COVID-19. This multicentered, prospective, and case-control study was conducted with polymerase chain reaction (+) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients, and an age-gender-matched control group. Samples were taken at the time of diagnosis and analyzed via flow cytometry within 24 h. The participants' demographic data and initial laboratory tests were also recorded. In total, 33 patients with COVID-19 (mean age = 45.4 +/- 17.2) and 25 controls (mean age = 43.4 +/- 17.4) participated in the study. All patients were identified as having mild (16), moderate (5), or severe (12) disease severity. Both early and late apoptotic cells in B and T lymphocytes were increased in all patients with COVID-19 (p < .05). Early apoptotic (EA) B and T lymphocytes were also higher in severe cases compared to mild cases (p = .026). There was no significant difference between lymphopenia and apoptosis in patients with COVID-19. However, patients with lymphopenia (n = 14) and severe COVID-19 (p = .013) had increased EA T lymphocytes. This study's results show that B and T lymphocytes' apoptosis increases in patients with COVID-19. In addition, enhanced T lymphocyte apoptosis is associated with disease severity in lymphopenic patients with COVID-19.Öğe An association between immune status and chest CT scores in COVID-19 patients(Wiley, 2021) Colkesen, Fatih; Poyraz, Necdet; Arslan, Sevket; Yilmaz, Pinar Diydem; Kurt, Esma Kepenek; Korkmaz, Celalettin; Yildiz, ErayBackground The characteristic features of the immune responses of COVID-19 patients and how they reflect lung involvement have not been clearly elucidated. Aim The aim of this study was to examine the immune status and the correlations thereof with chest CT scores and lung involvement of patients with COVID-19. Methods In this retrospective and single-center study, 72 patients with laboratory-confirmed COVID-19 were recruited. The counts of peripheral lymphocyte subsets (CD3(+) T cells, CD4(+) T cells, CD8(+) T cells, CD19(+) B cells and CD16(+) 56(+) NK cells) and those of serum immunoglobulins (IgA, IgG, IgM) were measured and their associations with chest CT scores analysed. Results The proportions of lymphopenia in patients with extensive lung involvement were twice that in the general study population. In the severe disease group, the levels of total lymphocytes, T cells, B cells, NK cells; and serum IgA levels, were significantly lower than in the mild disease group (all P < .05). We found that the numbers of lymphocyte subsets and the IgA level negatively correlated with the chest CT scores. On multivariate regression analysis, pretreatment decreases in total lymphocytes, CD3(+) T cells, CD4(+) T cells, and CD19(+) B cells, and serum IgA levels, were independent predictors of severe lung involvement. Conclusions The cell numbers of peripheral lymphocyte subsets and the serum IgA level were negatively correlated with the chest CT scores in COVID-19 patients. These parameters tended to independently predict severe lung involvement in such patients.Öğe The Association of Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios and Hematological Parameters with Diagnosis, Stages, Extrapulmonary Involvement, Pulmonary Hypertension, Response to Treatment, and Prognosis in Patients with Sarcoidosis(Hindawi Ltd, 2020) Korkmaz, Celalettin; Demircioglu, SinanSarcoidosis is a rare disease characterized by granulomatous inflammation in affected organs, primarily in lungs. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) are easy and practical methods providing valuable information in diagnosis, severity, and prognosis of various diseases. Here, we aimed to investigate the association between NLR, PLR, and hematological parameters in sarcoidosis. The study was performed with 75 sarcoidosis patients and 92 controls. Patients' NLR, PLR, and hematological parameters were compared with those of controls. Additionally, while differences between NLR and PLR were investigated in sarcoidosis patients, differences of extrapulmonary involvement, pulmonary hypertension (PH), and spontaneous remission between those with and without responses to treatment concerning stages were also assessed. NLR and PLR were significantly higher in sarcoidosis patients than controls. For NLR, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were found as 68, 61, 58, and 70% respectively, while sensitivity, specificity, PPV, and NPV for PLR were found as 72, 67, 63, and 74%, respectively. In sarcoidosis patients, NLR and PLR were significantly higher at stage-2 and -3 than at stage -1 and -4. There was a significant weak positive correlation between C-reactive protein (CRP) and NLR and PLR. Mean platelet volume (MPV), hemoglobin (Hgb), and mean corpuscular volume (MCV) were lower among patients than controls. A positive moderate correlation was detected between NLR and CD4/CD8 in blood, while there was a strong positive correlation between CD4/CD8 in bronchoalveolar lavage (BAL) and positive moderate correlation between PLR and CD4/CD8 in BAL. High NLR and PLR values were not significantly associated with pulmonary PH, spontaneous remission, response to treatment, and prognosis. The increase in PLR and NLR may be a guide for diagnoses of both sarcoidosis and lung parenchymal involvement. To use these entities as markers, our findings should be supported with prospective studies with larger samples.Öğe A case report of primary tuberculosis of the tongue(Modestum Ltd, 2017) Korkmaz, Celalettin; Daye, Munise; Teke, Turgut; Toy, Hatice; Hasal, Eda; Yavsan, Durdu MehmetAt present, the rate of extrapulmonary tuberculosis is gradually increasing among all tuberculosis cases. The secondary tuberculosis of oral cavity represents 0.2-1.5% of all cases with extrapulmonary tuberculosis. Although incidence of oral lesions secondary to pulmonary tuberculosis ranges from 0.4% to 1.5%, primary tuberculosis of the tongue occurs very rare, and it is published only as isolated case reports. A male patient presented to our dermatology clinic with complaints of painful ulcerated white plaques on the tip of his tongue lasting for three months, and an excisional biopsy showed granulomatous inflammation with caseification necrosis. Pulmonary and systemic examination showed no evidence of pulmonary or other extra-pulmonary tuberculosis, and he was initiated therapy for diagnosis of primary tuberculosis of the tongue. We found that the lesion completely resolved during the follow up visit after 1 month. Primary tuberculosis of the tongue should be for differential diagnosis of resistant painful oral lesions.Öğe Cigarette smoke and bleomycin-induced pulmonary oxidative stress in rats(Spandidos Publ Ltd, 2012) Teke, Turgut; Maden, Emin; Kiyici, Aysel; Korkmaz, Celalettin; Gok, Mehmet; Ozer, Faruk; Imecik, OktayBleomycin causes pulmonary fibrosis by increasing free oxygen radicals. Cigarette smoke is a strong oxidant which adversely affects pulmonary tissue. We evaluated the effects of cigarette smoke administered with intratracheal bleomycin on pulmonary tissue. We studied 3 groups of rats (n=10): one group received intratracheal saline and served as a control; one received intratracheal Neomycin (IT) (0.5 U/100 g body weight, single dose on the first day), and one group received intratracheal bleomycin (single dose on first day) and tobacco smoke (two times per day) (IT-S). After 4 weeks, the levels of malondialdehyde (MDA) and nitric oxide (NO) and the activities of superoxide dismutase (SOD) and xanthine oxidase (XO) were assayed in the homogenate of the lung tissue samples. The severity of interstitial fibrosis was assessed using the grading system described by Ashcroft. There was more intensive fibrosis in the IT and IT-S than in the control samples (P<0.001). The levels of MDA., NO and activity of XO were significantly increased (P<0.001, <0.002 and <0.002, respectively), and SOD activity (P<0.001) was significantly decreased in the IT group when compared to these values in the control group. The concentration of NO was significantly decreased (P<0.002), and SOD activity was significantly increased (P<0.05) in the lung tissue samples of the IT-S group. Theoretically, the combination of cigarette smoke and bleomycin may have a synergistic effect on oxidative lung injury. In conclusion, we showed that inhalation of cigarette smoke provides protection against oxidative stress in the lung tissue of rats with bleomycin-induced pulmonary fibrosis.Öğe Computed tomography findings in pulmonary involvement of wegener's granulomatosis: Pictorial review(Turkish Assoc Tuberculosis & Thorax, 2015) Poyraz, Necdet; Korkmaz, Celalettin; Yavsan, Durdu Mehmet; Keskin, Suat; Teke, Turgut; Odev, KemalWegener's granulomatosis is a necrotising granulomatous vasculitis which has a variable manifestations in the chest that are best described on computed tomography. Imaging findings may include masses or nodules, which may cavitate; consolidations and ground-glass opacities. Wegener's granulomatosis can mimic pneumonia, malignancy, and noninfectious inflammatory diseases. The purpose of this pictorial essay is to demonstrate the characteristic computed tomography findings of pulmonary Wegener's granulomatosis.Öğe Corneal confocal microscopy identifies corneal nerve fibre loss and increased dendritic cells in patients with long COVID(Bmj Publishing Group, 2022) Bitirgen, Gulfidan; Korkmaz, Celalettin; Zamani, Adil; Ozkagnici, Ahmet; Zengin, Nazmi; Ponirakis, Georgios; Malik, Rayaz A.Background/Aims Long COVID is characterised by a range of potentially debilitating symptoms which develop in at least 10% of people who have recovered from acute SARS-CoV-2 infection. This study has quantified corneal sub-basal nerve plexus morphology and dendritic cell (DC) density in patients with and without long COVID. Methods Forty subjects who had recovered from COVID-19 and 30 control participants were included in this cross-sectional comparative study undertaken at a university hospital. All patients underwent assessment with the National Institute for Health and Care Excellence (NICE) long COVID, Douleur Neuropathique 4 (DN4) and Fibromyalgia questionnaires, and corneal confocal microscopy (CCM) to quantify corneal nerve fibre density (CNFD), corneal nerve branch density (CNBD), corneal nerve fibre length (CNFL), and total, mature and immature DC density. Results The mean time after the diagnosis of COVID-19 was 3.7 +/- 1.5 months. Patients with neurological symptoms 4 weeks after acute COVID-19 had a lower CNFD (p=0.032), CNBD (p=0.020), and CNFL (p=0.012), and increased DC density (p=0.046) compared with controls, while patients without neurological symptoms had comparable corneal nerve parameters, but increased DC density (p=0.003). There were significant correlations between the total score on the NICE long COVID questionnaire at 4 and 12 weeks with CNFD (rho=-0.436; p=0.005, rho=-0.387; p=0.038, respectively) and CNFL (rho=-0.404; p=0.010, rho=-0.412; p=0.026, respectively). Conclusion Corneal confocal microscopy identifies corneal small nerve fibre loss and increased DCs in patients with long COVID, especially those with neurological symptoms. CCM could be used to objectively identify patients with long COVID.Öğe The effect of acute kidney injury on the success of non-invasive ventilation in COPD patients with hypercapnic respiratory failure(Kuwait Medical Assoc, 2020) Ince, Mahmut Sami; Teke, Turgut; Karagoz, Ali; Yucel, Fatih; Demirbas, Soner; Korkmaz, CelalettinObjective: To investigate the effect of acute kidney injury (AKI) on the success of noninvasive ventilation in chronic obstructive pulmonary disease (COPD) patients with hypercapnic respiratory failure Design: Retrospective observational cohort study Setting: Faculty of Meram Medicine, Necmettin Erbakan University, Konya, Turkey Subjects: This clinical study included 55 patients with decompensated COPD: 29 patients with AKI and 26 patients without AKI. Intervention: Demographical data, APACHE II scores, urea and creatinine values before non-invasive mechanical ventilation (NIMV) administration were recorded. Main outcome measures: The effect of AKI on the success of NIMV Results: There was no significant difference between sex, age and baseline respiratory rate of groups. There were statistically significant differences in baseline mean APACHE II score (21.4 +/- 5.3 vs 18.3 +/- 4.6, p=0.028), baseline mean pH (7.23 +/- 0.1 vs 7.30 +/- 0.1, p=0.001), urea (113.7 +/- 43.6 vs 45.2 +/- 13.0, p<0.001) and creatinine values (3.1 +/- 2.0 vs 0.9 +/- 0.3, p<0.001) of Group 1 and Group 2. Logistic regression analysis showed that none of these variable values tested have any effect on NIMV outcomes. Of the baseline variables tested, age (OR: 0.85; 95% CI: 0.69 to 1.07), sex (OR: 1.29; 95% CI: 0.89 to 1.89), baseline respiratory rate (OR: 1.02; 95% CI: 0.92 to 1.14), APACHE II score (OR: 1.03; 95% CI: 0.87 to 1.23), and AKI (OR: 0.79; 95% CI: 0.15 to 4.18) were not related to the outcome of NIMV in the logistic regression. Conclusions: We determined that AKI did not affect the outcome of NIMV in decompensated COPD patients.Öğe Effects of comprehensive and intensive pulmonary rehabilitation and nutritional support on quality of life and functional status in patients with chronic obstructive pulmonary disease(Sage Publications Ltd, 2020) Korkmaz, Celalettin; Demirbas, Soner; Vatansev, Hulya; Yildirmn, Elif; Teke, Turgut; Zamani, AdilObjective To investigate the effects of pulmonary rehabilitation (PR) and combined nutritional support therapy on quality of life (QoL) and functional status in patients with chronic obstructive pulmonary disease (COPD). Methods This pre-and post-intervention prospective exploratory study involved 64 patients with stable stage three to four COPD. Oral nutritional support and personalized diet were combined with an intense and comprehensive PR program. Baseline and 8-week follow-up scores were compared for the 6-minute walk test (6MWT), incremental shuttle walking test (ISWT), St. George's Respiratory Questionnaire (SGRQ), pulmonary function tests (PFT), PImax-PEmax, arterial blood gas (ABG), respiratory rate (RR), handgrip strength, Borg and modified Medical Research Council dyspnoea scale scores and fat-free mass index. Results Significant improvements were found in functional status (6MWT: 86.72 m, ISWT: 76.24 m), QoL (SGRQ total: 13.86), PFT, ABG, RR, dyspnoea, upper extremity muscle strength and hand-body composition. Conclusion Nutritional support with comprehensive and intensive PR can significantly improve physical performance, QoL, dyspnoea and body composition in COPD. The improvement in QoL was greater than that reported in previous studies. Because two modalities were combined in this study, future randomized controlled studies are needed to confirm the extent and contribution of these modalities to the outcomes.Öğe Evaluation of Serum Resistin, Visfatin, and Chemerin Levels in Patients with Lung Cancer and Chronic Obstructive Pulmonary Disease(Aves, 2020) Goktepe, Mustafa; Korkmaz, Celalettin; Zamani, Adil; Demirbas, Soner; Kilinc, IbrahimOBJECTIVES: Cachexia is an important problem in lung cancer and chronic obstructive pulmonary disease (COPD). Some studies report an association between adipokines and cachexia. Our study aimed to investigate the association of three novel adipokines, resistin, visfatin, and chemerin, with lung cancer and COPD. MATERIALS AND METHODS: 30 patients with non-smallcell lung cancer, 30 patients with COPD, and 30 healthy volunteers were included in the study. Statistically significant weight loss was found in COPD and lung cancer groups compared with that in the control group (p<0.001). Among the biomarkers, only resistin levels were significantly higher in patients with cachexia than in patients without weight loss in all groups (p=0.006). Resistin level was significantly higher in patients with COPD (p=0.002). Visfatin level was significantly higher in the control group (p=0.001). We found that a higher biomass exposure resulted in a significant increase and decrease in resistin (p=0.007) and visfatin levels (p=0.001), respectively, in the patient groups. For all groups, no statistically significant relationship was found between chemerin levels and weight loss or other variables. RESULTS: No significant relationship was found between the biomarkers and lung cancer type, tumor stage, lymph node stage, and metastasis stage. There was no relationship between the biomarkers by tumor, node, and metastasis and COPD stages (p>0.05). We observed no findings strong enough to support the use of these molecules as markers of disease stage or cachexia. CONCLUSION: Resistin, visfatin, and chemerin cannot be used as potential biomarkers for lung cancer or COPD or for disease stage or cachexia.Öğe Gluteal region muscle metastasis from squamous cell lung carcinoma(Modestum Ltd, 2017) Korkmaz, Celalettin; Yolacan, Ramazan; Teke, Turgut; Yavsan, Durdu MehmetLung cancer is known as a disease leading to metastases to all types of organs. Although covering a large part of the body and of much blood building-up, skeletal muscles are rare metastatic areas. In autopsies, less than 1% of malignant cancers that are spread hematogenously is known to lead to metastasis. A 51-year-old male patient diagnosed with squamous cell lung cancer and known to be in regression via screening after the administration of 32-day curative radiotheraphy and 6-cycle chemotherapy, the patient was radiologically followed-up. Four months later, he was admitted to outpatient clinic with the complaint of left hip pain. Magnetic resonance imaging revealed a lesion of nodular, necrotic metastatic mass within left gluteus muscles. As a result of tru-cut biopsy performed for the solid lesion, metastasis of carcinoma was detected. As also in our case, metastatic muscle disease should be suspected in patients with muscle pain.Öğe An impressive image of unilateral pulmonary artery agenesis associated with coronary collateralization in an adult(Turkish Soc Cardiology, 2020) Alsancak, Yakup; Tatar, Sefa; Gurbuz, Ahmet Seyfeddin; Korkmaz, Celalettin; Duzenli, Mehmet Akif[Abstract Not Availabe]Öğe An impressive image of unilateral pulmonary artery agenesis associated with coronary collateralization in an adult(Turkish Soc Cardiology, 2020) Alsancak, Yakup; Tatar, Sefa; Gurbuz, Ahmet Seyfeddin; Korkmaz, Celalettin; Duzenli, Mehmet Akif[Abstract Not Availabe]Öğe Inflammatory myofibroblastic tumor of the lung: histopathology and imaging findings(Turkish Assoc Tuberculosis & Thorax, 2020) Poyraz, Necdet; Yazar, Mehmet Emin; Kilinc, Fahriye; Korkmaz, Celalettin; Altinok, TamerInflammatory myofibroblastic tumor is a neoplasia of unknown clinical etiology that clinically and radiologically tends to mimic a malignant neoplasm. The tumor is histologically composed of a mixture of inflammatory cells, myofibroblastic spindle cells and plasma cells. It can occur in any part of the body. Although pulmonary inflammatory myofibroblastic tumor is the most common primary lung mass especially in childhood, this entity is usually not considered in differential diagnosis of lung nodules or masses. In this article, we aimed to disscus the pathology and imaging findings of the pulmonary inflammatory myofibroblastic tumor and increase the familiarity of radiologists and clinicians to this entity.Öğe Konya'da hayvan yemi üretiminde çalışan işçilerde mesleksel astım prevalansı(2008) Korkmaz, Celalettin; Özer, FarukKonya'da Hayvan Yemi Üretiminde Çalışan İşçilerde Mesleksel Astım PrevalansıAmaç: Hayvan yemi tozuna maruziyet ile oluşan solunumsal semptomların tespiti, solunum fonksiyonlarında meydana gelen değişiklilerin belirlenmesi, mesleksel astım ile atopi arasındaki ilişkinin gösterilmesi ve yem tozuna maruziyet sonucu gelişen mesleksel astım prevalansının saptanmasıdır.Materyal ve metod: Konya'da faaliyet gösteren 15 adet yem fabrikasında çalışan yem tozuna maruziyeti olduğu bilinen 139 erkek işçi, solunumsal semptomlar, atopi semptomları ve solunum fonksiyon testleri yönünden değerlendirildi. İşçilerin bulguları benzer yaş ve aynı cinsiyette olan 61 adet toza maruziyeti olmayan yem fabrikası çalışanından oluşan kontrol grubunun bulguları ile kıyaslandı. Tüm olgulara solunum ve atopi semptomlarını tespit için yüzyüze görüşme yöntemi ile bir anket uygulandı ve taşınabilir bir spirometri ile tüm olguların işyerinde solunum fonksiyon testleri ölçüldü. Anketle astım semptomu tespit edilen olguların akciğer grafileri çekildi ve bu olgulara cilt prick testi yapıldı.Bulgular: Çalışmaya 139 işçi ve 61 kontrol olmak üzere 200 erkek yem fabrikası çalışanı katıldı. İşçilerin yaş ortalaması 35,68±8.26 (16-53), kontrol grubunun yaş ortalaması 35,52±8.18 (21-56) idi. Yem üretiminde çalışan işçilerde mesleksel astım prevalansı % 19,4 olarak saptandı. Solunum semptomlarından hışıltılı solunum (% 25,1), nefes darlığı (% 22,3), öksürük (% 18,7), işçilerde daha yüksek bulundu. Ancak istatistiksel olarak anlamlı değildi ( sırasıyla p=0.28 , p=0.07 , p=0.66). Solunum fonksiyon testi değerleri işçilerde (FVC:4.90±0.92 FEV1: 3.97±0.78 PEF: 8.23±2.0 FEF25-75: 3.97±1.1) kontrol grubuna göre düşük bulundu ancak bu düşüklük anlamlı değildi (sırasıyla p=0.09 , p=0.18, p=0.22, p=0.46). Çalışma grubunda atopi semptomlarından gözlerde yaşarma (% 7,9), hapşırma (% 6,4), burun akıntısı (% 3,5) önde gelen semptomlardı ancak kontrol grubuyla arasında fark yoktu. Semptomlardan hışıltılı solunum, sigara kullanan işçilerde kullanmayanlara göre istatistiksel olarak anlamlı olmamakla birlikte belirgin derecede fazla görüldü, solunum fonksiyon testlerinden FVC, FEV1 ve FEF25-75 parametreleri anlamlı derecede daha düşük saptandı (sırasıyla. p=0.013 , p=0.003, p=0.017). Cilt prick testi, semptomu olan 42 kişden 10 (% 23,8) kişide pozitifti, mesleksel astımı olanlarla olmayanlar arasında fark bulunmadı. Çalışma esnasında maske kullanan işçilerle kullanmayan işçiler arasında semptomlar ve solunum fonksiyonları açısından anlamlı fark saptanmadı.Sonuç: Sonuç olarak hayvan yemi tozuna maruziyet, solunumsal semptomların ortaya çıkmasında, solunum fonksiyonlarında düşüşte önemli rol oynamaktadır, sigara kullanımı durumunda bu etki daha belirgin olmaktadır, maske kullanımının koruyuculukta yeterli etkisi yoktur. Mesleksel astım ile atopi arasında birebir korelasyon olmadığı görülmüştür.Öğe Memory B cells and serum immunoglobulins are associated with disease severity and mortality in patients with COVID-19(Oxford Univ Press, 2022) Colkesen, Fatih; Kepenek Kurt, Esma; Vatansev, Hulya; Korkmaz, Celalettin; Colkesen, Fatma; Yucel, Fatih; Yildiz, ErayPurpose of the study The aim of this study was to investigate the relationship of B cell-mediated immunity with disease severity and mortality in patients with COVID-19. Study design In this retrospective cohort and single-centre study, 208 patients with laboratory-confirmed COVID-19 were recruited. A COVID-19 severity score, ranging from 0 to 10, was used to evaluate associations between various factors. Serum immunoglobulin levels and the number of cells in B lymphocyte subsets were measured and their association with disease severity and mortality in patients with COVID-19 examined. Results The median age of the patients was 50 (35-63) years and 88 (42%) were female. The number of deceased patients was 17. The median COVID-19 severity score was 8 (6-8) in deceased patients and 1 (0-2) in survivors. Deceased patients had significantly lower levels of total B lymphocytes, naive B cells, switched memory B cells, and serum IgA, IgG, IgG(1) and IgG(2) than recovered patients (all p<0.05). In addition, a significant negative correlation was found between the number of these parameters and COVID-19 severity scores. Decrease in the number of total B cells and switched memory B cells as well as lower serum IgA, IgG and IgG(1) levels were independent risk factors for mortality in patients with COVID-19. Conclusion In the present study, the prognosis of patients with COVID-19 was shown to be associated with the B cell subset and serum immunoglobulin levels.Öğe Relationship between Selective IgA Deficiency and COVID-19 Prognosis(Natl Inst Infectious Diseases, 2022) Colkesen, Fatih; Kandemir, Bahar; Arslan, Sevket; Colkesen, Fatma; Yildiz, Eray; Korkmaz, Celalettin; Vatansev, HulyaThe prevalence and mortality rates of coronavirus disease 2019 (COVID-19) widely vary among populations. Mucosal immunity is the first barrier to the pathogen's entry into the body. Immunoglobulin A (IgA) is the primary antibody responsible for mucosal immunity. We explored the relationship between selective IgA deficiency (SIgAD) and COVID-19 severity. We included 424 patients (203 women) with COVID-19. Eleven patients had SIgAD. Laboratory data of patients with SIgAD and normal IgA levels were compared. The relationship between SIgAD and severe COVID-19 infection was explored using logistic regression analysis. In the univariate logistic regression analysis, the risk of severe COVID-19 disease in patients with SIgAD was approximately 7.7 -fold higher than that in other patients (odds ratio [OR], 7.789; 95% confidence interval [CI], 1.665-36.690, P = 0.008), while it was 4-fold (OR, 4.053; 95% CI, 1.182-13.903, P = 0.026) higher in the multivariate logistic regression analysis. Serum IgA levels were positively correlated with total lymphocyte counts and negatively correlated with C-reactive protein levels, which was a risk factor for severe COVID-19. In patients with SIgAD, the number of severe acute respiratory coronaviruses 2 that pass through mucosal membranes may be increased, leading to complications such as cytokine storm syndrome and acute respiratory distress syndrome.Öğe Thoracic Complications in Behcet's Disease: Imaging Findings(Hindawi Ltd, 2020) Odev, Kemal; Tunc, Recep; Varol, Salih; Aydemir, Harun; Yilmaz, Pinar Didem; Korkmaz, CelalettinBehcet's disease (BD) causes vascular inflammation and necrosis in a wide range of organs and tissues. In the thorax, it may cause vascular complications, affecting the aorta, brachiocephalic arteries, bronchial arteries, pulmonary arteries, pulmonary veins, capillaries, and mediastinal and thoracic inlet veins. In BD, chest radiograph is commonly used for the initial assessment of pulmonary symptoms and complications and for follow-up and establishment of the response to treatment. With the advancement of helical or multislice computed tomography (CT) technologies, such noninvasive imaging techniques have been employed for the diagnosis of vascular lesions, vascular complications, and pulmonary parenchymal manifestations of BD. CT scan (especially, CT angiography) has been used to determine the presence and severity of pulmonary complications without resorting to more invasive procedures, in conjunction with gadolinium-enhanced three-dimensional (3D) gradient-echo magnetic resonance (MR) imaging with the subtraction of arterial phase images. These radiologic methods have characteristics that are complementary to each other in diagnosis of the thoracic complications in BD. 3D ultrashort echo time (UTE) MR imaging (MRI) could potentially yield superior image quality for pulmonary vessels and lung parenchyma when compared with breath-hold 3D MR angiography.
