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Öğe COMPARISON OF POSTURAL CHANGES AND FUNCTIONAL LEVELS AMONG DIFFERENT SUBTYPES OF AXIAL SPONDYLOARTHRITIS PATIENTS(Bmj Publishing Group, 2023) Akkubak, Y.; Duger, T.; Kucuk, A.[Abstract Not Availabe]Öğe ENDOCAN LEVELS AND SUBCLINICAL ATHEROSCLEROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS(Bmj Publishing Group, 2018) Tuzcu, G.; Uslu, A. U.; Tuzcu, A.; Aydogan Baykara, R.; Omma, A.; Kucuk, A.[Abstract Not Availabe]Öğe Evaluation of restless legs syndrome and sleep disorders in patients with psoriatic arthritis(Springer Heidelberg, 2019) Sandikci, S. C.; Colak, S.; Baykara, R. Aydogan; Oktem, A.; Cure, E.; Omma, A.; Kucuk, A.Objectives. Restless legs syndrome (RLS) is a neurological disease with a chronic course that is characterised by sleep disorders and sensorimotor impairment. The aim of this study was to evaluate the prevalence and severity of RLS in psoriatic arthritis (PSA) patients and those with psoriasis (P). Patients and methods. The study included 50 patients with psoriasis (28 females, 22 males), 50 PSA patients (33 females, 17 males) and 50 healthy control subjects (34 females, 16 males), and all 3 groups were matched with respect to age, gender and body mass index (BMI). Evaluations were made using the International RLS Rating Scale, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale, Insomnia Severity Index, Fatigue Severity Scale (FSS), Beck Depression Index (BDI) and the SF-36 quality of life scores. Results. RLS was determined at a higher rate in the PSA patients (64.0%), compared to the P group (20.0%, p< 0.001) and the control group (14.0%, p< 0.001). The number of moderate and severe RLS cases was significantly higher in the PSA group (68.7%) compared to the P group (30%, p< 0.001) and the control group (0%, p< 0.001). In regression analysis, an independent correlation was found between the RLS score and PSQI (beta [beta]= 0.269, p= 0.002), FSS (beta= 0.243, p= 0.003), SF-36 physical score (beta= 0.242, p= 0.004) and BDI (beta= 0.177, p= 0.036). Conclusion. RLS was determined in PSA patients at a higher rate than in psoriasis patients. The presence of RLS in PSA and psoriasis patients is related to impairments in sleep and quality of life, fatigue and depression.Öğe THE FREQUENCY OF SJOGREN'S SYNDROME IN CELIAC PATIENTS; A CROSS-SECTIONAL CONTROLLED CLINICAL TRIAL(Bmj Publishing Group, 2015) Ayar, K.; Tunc, R.; Pekel, H.; Kucuk, A.; Esen, H. R.; Cifci, S.; Ataseven, H.[Abstract Not Availabe]Öğe The LDL/HDL ratio and atherosclerosis in ankylosing spondylitis(Springer Heidelberg, 2017) Kucuk, A.; Uslu, A. Ugur; Icli, A.; Cure, E.; Arslan, S.; Turkmen, K.; Toker, A.In ankylosing spondylitis (AS) patients, cardiac and vascular involvement may manifest as atherosclerosis and coronary artery disease. Systemic inflammation, oxidative stress, increased low-density lipoprotein (LDL) cholesterol and decreased high-density lipoprotein (HDL) cholesterol constitute a significant risk for atherosclerosis. This study investigated the relationship between carotid intima-media thickness (CIMT), LDL/HDL ratio, total oxidant status (TOS; an indicator of oxidative stress) and ischemic modified albumin (IMA; an ischemic marker in AS patients). Sixty AS patients were diagnosed using the Modified New York Criteria; 54 age- and gender-matched participants were included as controls. CIMT, LDL/HDL ratio, TOS and IMA were measured using the most appropriate methods. IMA was higher in AS patients compared to controls (p < 0.0001). TOS was also increased in AS patients (p = 0.005); as was CIMT (p < 0.0001). The LDL/HDL ratio was also greater in AS patients compared to controls (p = 0.047). A positive correlation was found between CIMT and LDL/HDL ratio among AS patients. Elevated CIMT, IMA and TOS levels suggest an increased risk of atherosclerotic heart disease in AS patients. The LDL/HDL ratio was higher in AS patients compared to controls, and there was a correlation between LDL/HDL ratio and CIMT, albeit statistically weak. Therefore, the LDL/HDL ratio is not a reliable marker to predict atherosclerotic heart disease in AS patients.Öğe LUMBOPELVIC STABILITY, TRUNK POSITION SENSE, AND SPINE POSTURE IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS(Bmj Publishing Group, 2022) Akkubak, Y.; Duger, T.; Kucuk, A.[Abstract Not Availabe]Öğe Neutrophil-to-lymphocyte ratio is involved in the severity of ankylosing spondylitis(Comenius Univ, 2015) Kucuk, A.; Uslu, A. U.; Ugan, Y.; Bagcaci, S.; Karahan, A. Y.; Akannut, A.; Sahin, A.OBJECTIVE: Ankylosing spondylitis (AS) is a progressive chronic inflammatory disease mainly characterized by axial skeleton and sacroiliac joint involvement. We aimed to investigate the relation between neutrophil-to-lymphocyte ratio (NLR) and disease severity of AS and to explore its availability in clinical practice. METHODS: A total of 102 AS patients and 60 individuals who were age- and gender-compatible with the control group were included into the study. Patients were divided into 2 groups according to Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores. Patients with BASDAI scores <4 were considered to be having mild disease activity, whereas those with scores 4 were considered to be displaying severe disease activity. Hemogram test during the diagnosis, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and other laboratory values of the control group were recorded. RESULTS: NLR was observed to be higher in AS patients compared to the controls (2.47 +/- 1.33 and 1.72 +/- 0.47; respectively; p<0.0001). NLR was observed to be significantly higher in severe AS disease activity compared to the mild AS disease activity (2.72 +/- 1.41, 2.20 +/- 1.19; respectively; p = 0.001). NLR had statistical significant differences between mild disease activity compared to the controls (2.20 +/- 1.19 and 1.72 +/- 0.47, respectively; p = 0.263). There was a positive correlation between NLR and BASDAI (r = 0.193, p = 0.041). The performance of NLR evaluating the disease severity by Roc analysis had sensitivity of 69%, specificity of 54% (cut-off value 1.91), and AUC of 0.652 (95% Cl, 0.549-0.755) (p = 0.006). CONCLUSIONS: NLR may be a simple and inexpensive marker to indicate disease activity in patients with AS in daily clinical practice (Tab. 3, Fig. 3, Ref. 25). Text in PDF www.elis.sk.Öğe NEUTROPHIL/ LYMPHOCYTE RATIO AND MEAN PLATELET VOLUME IN BEHCET'S DISEASE(Bmj Publishing Group, 2015) Balkarli, A.; Kucuk, A.; Babur, H.; Erbasan, F.[Abstract Not Availabe]Öğe Neutrophil/lymphocyte ratio and mean platelet volume in Behcet's disease(Verduci Publisher, 2016) Balkarli, A.; Kucuk, A.; Babur, H.; Erbasan, F.OBJECTIVE: With this retrospective study, we researched the effects of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) on the activity of Behcet's disease and susceptibility to thrombosis. PATIENTS AND METHODS: One hundred eighty- six patients with Behcet's disease, who met the inclusion criteria, were separated into two groups: 120 patients had active Behcet's disease (Group I) and 66 patients with inactive Behcet's disease (Group II). 79 healthy subjects as controls were included in the study. RESULTS: MPV was similar between all three groups. CRP (C reactive protein) was statistically higher in the active BD group when compared to the inactive BD group and the control group. CRP of the inactive BD and the healthy control group were similar. In addition, erythrocyte sedimentation rate (ESR) was found higher than the control group in both active and inactive BD groups, whereas ESR of the active BD group was higher than the inactive BD group. N/L ratio was found statistically higher in the active BD group when compared to inactive BD and healthy control groups, while the N/L ratio of inactive BD and healthy control groups were found similar to each other. While MPV, CRP, and NLR didn't statistically differ between active BD subgroups with and without thrombosis, ESR was statistically and significantly higher in the active BD group with thrombosis when compared to the active BD group without thrombosis. CONCLUSIONS: The data obtained from the present study showed that the patients with BD are exposed to chronic inflammation. And the N/L ratio may be a simple, inexpensive, and convenient diagnostic marker of active BD.Öğe Prevalence of sicca symptoms and Sjogren's syndrome in coeliac patients and healthy controls(Taylor & Francis Ltd, 2020) Ayar, K.; Tunc, R.; Pekel, H.; Esen, H. H.; Kucuk, A.; Cifci, S.; Ataseven, H.Objective: There has been no previous study comparing the frequency of sicca symptoms and Sjogren's syndrome (SS) in coeliac patients (CPs) and healthy controls (HCs) using a tight screening method. The aim of this study was to compare the frequency of sicca symptoms and SS in HCs and CPs. Method: The study included 80 CPs and 100 HCs. This study was designed as a case-control study with four phases. The frequency of SS in CPs and HCs was defined according to the 2002 American-European Consensus Group (AECG) and 2012 American College of Rheumatology (ACR) classification criteria. The frequency of sicca symptoms and SS was compared between CPs and HCs. Results: Ocular and oral symptoms occurred in 22% and 26% of CPs, respectively, compared to 13% and 10% of HCs, respectively. Proportions with oral symptoms were statistically significantly different between CPs and HCs (p = 0.005), whereas there was no significant difference for ocular symptoms (p = 0.113). According to ACR and AECG criteria, the prevalence of SS was 3.8% and 5.0% in CPs and 3.0% and 2.0% in HCs, respectively. Conclusion: Although oral symptoms were more frequent in CPs than in HCs, the frequency of SS was not different between the groups. The increased frequency of oral symptoms may be related to reasons other than autoimmunity.Öğe THE RELATION BETWEEN INFLAMMATION, CAROTID INTIMA-MEDIA THICKNESS AND LOW-DENSITY LIPOPROTEIN CHOLESTEROL-HIGH-DENSITY LIPOPROTEIN CHOLESTEROL RATIO IN ANKYLOSING SPONDYLITIS PATIENTS(Bmj Publishing Group, 2015) Kucuk, A.; Uslu, A. U.; Arslan, S.; Turkmen, K.; Toker, A.; Kayrak, M.[Abstract Not Availabe]Öğe THE RELATIONSHIP BETWEEN SEXUAL QUALITY OF LIFE AND CLINICAL FEATURES IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS(Bmj Publishing Group, 2022) Akkubak, Y.; Kucuk, A.[Abstract Not Availabe]Öğe Serum endocan levels in patients with ankylosing spondylitis(Wiley-Blackwell, 2016) Ankarali, S.; Toker, A.; Uysal, S.; Kucuk, A.; Kayrak, M.[Abstract Not Availabe]Öğe SEVER DISEASE: AN IMPORTANT CAUSE OF HEEL PAIN IN CHILDREN: CASE REPORT(Springer London Ltd, 2014) Tekin, L.; Karahan, A. Y.; Tekin, A. N.; Kucuk, A.[Abstract Not Availabe]Öğe TREATMENT SATISFACTION, EXPECTATIONS, PATIENT PREFERENCES, AND CHARACTERISTICS IN PATIENTS WITH RHEUMATOID ARTHRITIS (RA): TURKISH COHORT RESULTS OF THE SENSE STUDY(Bmj Publishing Group, 2021) Kalyoncu, U.; Kucuk, A.; Sargin, G.; Ozdener, F.; Yolba, S.; Yurttas, B.; Turan, S.[Abstract Not Availabe]
