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Öğe Agomelatine has relaxant effect on isolated rat thoracic aorta through nitric oxide dependent mechanism(Wiley-Blackwell, 2015) Solak, H.; Koca, Ozen R.; Nurullahoglu-Atalik, K. E.; Kutlu, S.[Abstract Not Availabe]Öğe Assessment of myocardial protection with new biochemical markers during on-pump coronary bypass surgery(Wiley-Blackwell, 2014) Gormus, Z. I. Solak; Cicek, M. C.; Solak, H.; Gormus, N.; Kutlu, S.[Abstract Not Availabe]Öğe Cilostazol enhances atorvastatin-induced vasodilation of female rat aorta during aging(Akademiai Kiado Zrt, 2017) Nurullahoglu-Atalik, K. E.; Kutlu, S.; Solak, H.; Koca, R. OzenStatins have cholesterol-independent effects including an increased vascular nitric oxide activity and are commonly used by patients with cardiovascular disease. Such patients frequently have cardiovascular diseases, which may be treated with cilostazol, a platelet aggregation inhibitor. This study was designed to investigate whether combined use of cilostazol would increase the inhibitory effect of statin on vascular smooth muscle and how maturation would affect these responses. Female Wistar rats, aged 3-4 months (young) and 14-15 months (adult), were sacrificed by cervical dislocation and the thoracic aorta was dissected and cut into 3- to 4-mm-long rings. The rings were mounted under a resting tension of 1 g in a 20-ml organ bath filled with Krebs-Henseleit solution. Rings were precontracted with phenylephrine (10(-6) M), and the presence of endothelium was confirmed with acetylcholine (10(-6) M). Then, the concentration-response curves were obtained for atorvastatin alone (10(-10) to 3 x 10(-4) M; control) and in the presence of cilostazol (10(-6) M) in young and adult rat aortas. This experimental protocol was also carried out in aorta rings, which had been pretreated with NG-nitro-L-arginine methyl ester (L-NAME, 10(-4) M). Atorvastatin induced concentration-dependent relaxations in young and adult rat thoracic aorta rings precontracted with phenylephrine. The pIC(50) value of atorvastatin was significantly decreased in adult rat aortas. In addition, pretreatment of aortas with cilostazol enhanced the potency of atorvastatin in both young and adult aortas. Incubation with L-NAME did not completely eliminate the relaxations to atorvastatin in the presence of cilostazol. These results suggest that combined application of cilostazol with atorvastatin was significantly more potent than atorvastatin alone. Combined drug therapy may be efficacious in delaying the occurrence of cardiovascular events.Öğe Cilostazol enhances atorvastatin-induced vasodilation of female rat aorta during aging(Akademiai Kiado Zrt, 2017) Nurullahoglu-Atalik, K. E.; Kutlu, S.; Solak, H.; Koca, R. OzenStatins have cholesterol-independent effects including an increased vascular nitric oxide activity and are commonly used by patients with cardiovascular disease. Such patients frequently have cardiovascular diseases, which may be treated with cilostazol, a platelet aggregation inhibitor. This study was designed to investigate whether combined use of cilostazol would increase the inhibitory effect of statin on vascular smooth muscle and how maturation would affect these responses. Female Wistar rats, aged 3-4 months (young) and 14-15 months (adult), were sacrificed by cervical dislocation and the thoracic aorta was dissected and cut into 3- to 4-mm-long rings. The rings were mounted under a resting tension of 1 g in a 20-ml organ bath filled with Krebs-Henseleit solution. Rings were precontracted with phenylephrine (10(-6) M), and the presence of endothelium was confirmed with acetylcholine (10(-6) M). Then, the concentration-response curves were obtained for atorvastatin alone (10(-10) to 3 x 10(-4) M; control) and in the presence of cilostazol (10(-6) M) in young and adult rat aortas. This experimental protocol was also carried out in aorta rings, which had been pretreated with NG-nitro-L-arginine methyl ester (L-NAME, 10(-4) M). Atorvastatin induced concentration-dependent relaxations in young and adult rat thoracic aorta rings precontracted with phenylephrine. The pIC(50) value of atorvastatin was significantly decreased in adult rat aortas. In addition, pretreatment of aortas with cilostazol enhanced the potency of atorvastatin in both young and adult aortas. Incubation with L-NAME did not completely eliminate the relaxations to atorvastatin in the presence of cilostazol. These results suggest that combined application of cilostazol with atorvastatin was significantly more potent than atorvastatin alone. Combined drug therapy may be efficacious in delaying the occurrence of cardiovascular events.Öğe Effect of boron on spontaneous and oxytocin induced contraction in rat myometrium(Wiley-Blackwell, 2014) Kutlu, S.; Akgunlu, M.; Solak, H.; Gormus, Z. I. Solak; Uysal, H.; Ergene, N.[Abstract Not Availabe]Öğe Effects of agomelatine on electrocorticogram activity on penicillin-induced seizure model of rats(Elsevier Ireland Ltd, 2019) Ethemoglu, M. S.; Kutlu, S.; Seker, F. B.; Erdogan, C. S.; Bingol, C. A.; Yilmaz, B.Agomelatine is a new antidepressant drug acting as an antagonist of 5-hydroxytryptamine receptor 2C (5-HTR2c) and agonist of melatonergic receptors 1 and 2 (MT1 and MT2). Because of this dual action, it is an atypical antidepressant. The aim of this study was to investigate chronic anticonvulsant effects of agomelatine on penicillin-induced epilepsy model. Adult male Sprague Dawley rats divided into four groups and were administered with tap water (vehicle), and agomelatine doses of 10 mg/kg, 50 mg/kg and 100 mg/kg for 14 days via oral gavage. After the last doses were given, epileptic seizures were induced by intracortical penicillin (500 IU/2.5 mu l) application in rats under urethane (1.25 g/kg intraperitoneal) anesthesia. Electrocorticogram (ECoG) recordings were obtained from the somatomotor cortex through 90 min, and spike frequencies and amplitudes were analyzed. The spike frequency analyses revealed that only 50 mg/kg agomelatine administration decreased the spike frequencies of hypersynchronous discharge of neurons caused by penicillin (p < 0.05). No significant differences in amplitudes between experimental groups were observed. In addition, mRNA expressions of vesicular glutamate transporter 1 (VGLUT1) and vesicular gamma-aminobutyric acid transporter (VGAT) in response to the agomelatine active dose, 50 mg/kg, showed no significant effect of agomelatine on the mRNA expression. Our results indicate that chronic treatment with agomelatine may have potential anticonvulsant effects. Agomelatine may be a promising drug for epilepsy patients having depression due to its antiepileptic and antidepressant effects.Öğe Effects of Sertraline in Healthy and Damaged Rat Aorta(Wiley, 2017) Koc, A.; Gormus, Z. I. Solak; Solak, H.; Koca, R. Ozen; Sahin, Z.; Gormus, N.; Kutlu, S.[Abstract Not Availabe]Öğe Is alarin really a novel hormone for reproduction?(Wiley, 2019) Gormus, Solak Z., I; Koca, Ozen R.; Solak, H.; Sahin, Z.; Kutlu, S.[Abstract Not Availabe]Öğe Possible Effects of Sertraline on Human Heart Muscle Contractility: An in vitro experimental study(Wiley, 2017) Solak, H.; Gormus, Z. I. Solak; Koca, R. Ozen; Koc, A.; Karaibrahimoglu, A.; Kutlu, S.; Gormus, N.[Abstract Not Availabe]
