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Öğe Comparison of Fluoxetine and Sertraline in Treatment of Postoperative Depression(Wiley, 2018) Gormus, Z. Isik Solak; Gormus, Niyazi; Solak, Hatice; Koca, Raviye Ozen; Koc, Aynur; Taki, Fatma Nur; Kutlu, Selim[Abstract Not Availabe]Öğe A different marker to determine arrhythmia potential between elite active cyclists and veterans: T peak T end(Wiley-Blackwell, 2015) Gormus, Z. Isik Solak; Isik, Bulent; Ciftci, Ozgur; Icli, Abdullah; Togan, Turhan; Aslan, Huseyin; Kutlu, Selim[Abstract Not Availabe]Öğe Does Fluoksetine Reduce Positive Inotropic Effect of Heart?(Wiley, 2018) Gormus, Z. Isik Solak; Koca, Raviye Ozen; Solak, Hatice; Kutlu, Selim; Gormus, Niyazi[Abstract Not Availabe]Öğe Does Neurokinin 3 Receptor Agonism Affect Hippocampal Neurogenesis in an Experimental Rat Model of Alzheimer's Disease?(Wiley, 2023) Koca, Raviye Ozen; Gormus, Z. Isik Solak; Solak, Hatice; Celik, Fatma Secer; Kurar, Ercan; Kutlu, Selim[Abstract Not Availabe]Öğe Does Phosphodiesterase Inhibiting Agent-Milrinone Prevent Negative Inotropic Effects of Sertraline on Postoperative Human Heart Muscle Contractility? An In Vitro Experimental Study(Wiley, 2017) Gormus, Zulfikare Isik Solak; Koca, Raviye Ozen; Koc, Aynur; Solak, Hatice; Ozdemir, Ayse; Sahin, Zafer; Kutlu, Selim[Abstract Not Availabe]Öğe Does Sertraline Affect Hypothalamic Food Intake Peptides in the Rat Experimental Model of Chronic Mild Stress-Induced Depression?(Springer/Plenum Publishers, 2022) Solak, Hatice; Gormus, Z. Isik Solak; Koca, Raviye Ozen; Gunes, Canan Eroglu; Kutlu, SelimDepression is a chronic, recurrent and life-threatening disease affecting approximately 15% of the world population. Depression is responsible for neuropathologies like decreased neurogenesis and increased dendritic atrophy. Antidepressant treatments increase hippocampal neurogenesis and neurotrophic factor expression. Based on this information, it was aimed to investigate effect of sertraline on depression in rats with chronic mild stress (CMS) model and to determine how it affects cell proliferation and hypothalamic peptide levels in hypothalamus. 56 adult male Wistar albino; control, depression(D), depression + sertraline, sertraline were divided into groups. Various stressors were applied to D for 30 days. Open field test (OFT) and forced swimming test (FST) were conducted to check whether the animals were depressed. On the 16th day osmotic minipump was placed subcutaneously and sertraline (10 mg/kg/day) was administered for 15 days. Behavior tests were done. Hypothalamic peptide gene expression levels were analyzed by quantitative RT-PCR. Statistical evaluations were made using ANOVA. It caused a decrease in the percentage of movement in the D and control groups in the OFT, an increase in the immobility time in the D group in the FST, and an increase in the swimming behavior in the DS group. Animals did not show any anxiological behavior based on the elevated plus maze test results. CMS caused a decrease in GLUT2 and NPY gene expression in the hypothalamus of animals, an increase in POMC and FGFR2, and an increase in IGFIR and GLUT2 gene expression in the DS group. Sertraline has been shown to ameliorate the effects of CMS-induced depression. Sertraline is thought to have a positive regulatory effect on both the formation of neural precursor cells and the survival of newly formed neurons in the hypothalamus. Newly formed neurons in the hypothalamus express food intake-related NPY, POMC, GLUT2 neurons, and thus hypothalamic tanycytes may play a key role in the control of energy metabolism.Öğe Effect of Apelin on Anxiety Like Behaviour in Male Rats(Karger, 2021) Sak, Zeynep Caliskan; Kutlu, Selim; Ozkurkculer, Alpaslan; Koca, Raviye Ozen; Solak, Hatice; Gormus, Zisik Solak[Abstract Not Availabe]Öğe Effect of Intravenous Glucose Administration on Catecholamine Concentrations in Hypothalamic Ventromedial Nucleus in Rats: A Microdialysis Study(Wiley-Blackwell, 2016) Solak, Hatice; Koca, Raviye Ozen; Gormus, Z. Isik Solak; Sahin, Zafer; Koc, Aynur; Karaibrahimoglu, Adnan; Kutlu, Selim[Abstract Not Availabe]Öğe Effect of kisspeptin on calcium signalling in cultured rHypoE-8 cell line(Wiley-Blackwell, 2015) Kutlu, Selim; Ozdemir, Gokcen; Sahin, Zafer; Ozcan, Mete; Canpolat, Sinan; Kelestimur, Haluk[Abstract Not Availabe]Öğe The Effect of Morphine Dependence and Morphine Withdrawal on Neuritin and Some Markers of Neurogenesis in the Rat Hippocampus(Wiley, 2023) Cimen, Yasin Ali; Yildiz, Ibrahim; Gunes, Canan Eroglu; Ozkurkculer, Alpaslan; Kurar, Ercan; Kutlu, Selim[Abstract Not Availabe]Öğe Effect of Morphine Dependency on Apelinergic System in Rat Hippocampus(Wiley, 2022) Yildiz, Ibrahim; Cimen, Yasin Ali; Eroglu, Canan; Ozkurkculer, Alpaslan; Kurar, Ercan; Kutlu, Selim[Abstract Not Availabe]Öğe Effect of Naloxone Precipitated Morphine Withdrawal on Melatonin Receptor Expressions in Hippocampus and Hypothalamus Tissues in Morphine Dependent Rat(Karger, 2021) Cimen, Yasin Ali; Gunes, Canan Eroglu; Yildiz, Ibrahim; Ozdengul, Faik; Kurar, Ercan; Meral, Ismail; Kutlu, Selim[Abstract Not Availabe]Öğe Effect of Neurokinin 3 Receptor on Cognitive Behavior and Catecholaminergic System in a Rat Experimental Alzheimer Model(Wiley, 2019) Koca, Raviye Ozen; Solak, Hatice; Gormus, Zulfikare Solak; Kutlu, Selim[Abstract Not Availabe]Öğe The Effect of Phenoxybenzamine to Decreased Heart Muscle Contractility After in vitro Constituted Ischemia(Wiley-Blackwell, 2016) Gormus, Z. Isik Solak; Solak, Hatice; Koca, Raviye Ozen; Sahin, Zafer; Kutlu, Selim; Gormus, Niyazi[Abstract Not Availabe]Öğe Effect of RFRP-3 on Anxiety-like Behaviour and Hippocampal Neurogenesis in Rats(Wiley-Blackwell, 2016) Boyukcam, Yasemin; Sahin, Zafer; Koc, Aynur; Eroglu, Canan; Gormus, Isik Solak; Kurar, Ercan; Kutlu, Selim[Abstract Not Availabe]Öğe The Effect of Sertraline on Cognitive Behaviors in Depressed Rats with Chronic Mild Stress Model(Wiley, 2022) Solak, Hatice; Gormus, Z. Isik Solak; Koca, Raviye Ozen; Kurar, Ercan; Kutlu, Selim[Abstract Not Availabe]Öğe Effects of Agomelatineon Penicillin-Induced Epilepsy with Electrocorticogram and Blood Pressure(Wiley-Blackwell, 2016) Ethemoglu, Sinem Muhsine; Seker, Burcu; Kutlu, Selim; Yilmaz, Bayram[Abstract Not Availabe]Öğe The effects of apelin on myometrium contractions in pregnant rats(C M B Assoc, 2018) Kacar, Emine; Ercan, Zubeyde; Serhatlioglu, Ihsan; Sumer, Aysegul; Kelestimur, Haluk; Kutlu, SelimApelin, which is a new hormone, is secreted especially in the brain by hypothalamus as well as by many other organs like the stomach, fat tissue, and the heart. For apelin, whose possible effects on many bodily functions like the endocrine system, cardiovascular system and metabolic activities are still under investigation, the reproductive system is also an important target area. The purpose of the present study was to investigate the effects of plasma apelin levels in rats that were in diestrus, pregnancy and lactation periods, and to examine its possible effects on myometrium contractions of pregnant rats and non-pregnant rats that were in diestrus period. The plasma apelin concentrations in female adult Wistar rats were determined with the ELISA method in the diestrus period, and on the 12th, 18th, and 21st days of the pregnancy, and on the 2nd and 10th days of lactation (n=7 for each group). In addition, the effect of apelin at 0.01, 0.1, 1 and 10 mu M doses on isometric contractions in the rat uterus on the 21st day of pregnancy and in diestrus period was tested by using isolated organ bath. This protocol was repeated under conditions that were pre-treated with protein kinase C inhibitor in calcium-free medium, and the possible effect of apelin on contractions and the mechanisms that might mediate this effect were investigated. When plasma apelin levels were compared with the rats in diestrus period, the apelin concentrations in the 21-day pregnancy group were high at a significant level (p<0.05); and low at a significant level in the 2-day lactation group (p<0.05). In myometrium contraction trials, it was observed that apelin induced the contractions. Apelin increased the frequency of the myometrium contractions at a significant level when applied at 1 mu M and 10 mu M concentrations (p<0.05 and p<0.001). Only after the apelin application at 10 mu M concentration did the amplitude of the contractions increase at a significant level (p<0.01). In the myometrium of the rats that were on the 21st day of pregnancy, the frequency of the contractions was statistically significant at 0.1 mu M, 1 mu M and 10 mu M doses (p<0.01). In addition, the amplitude of the contractions increased at a statistically significant level at 1 mu M and 10 mu M dose application (p<0.05 and p<0.01, respectively). The apelin application induced the contractions in calcium-free medium. When apelin was applied after the pre-application with protein kinase C inhibitor, no contractions were observed. The present study showed that apelin levels were increased at the end of pregnancy in rats, and the hormone induced the uterus contractions. This effect does not occur with protein kinase C inhibitor and in calcium-free medium, which shows that protein kinase C pathway might play a role in these mechanism. These findings show that apelin might be an endogenous peptide that plays a role on uterine contractions at birth in rats.Öğe The effects of apelin on myometrium contractions in pregnant rats(C M B Assoc, 2018) Kacar, Emine; Ercan, Zubeyde; Serhatlioglu, Ihsan; Sumer, Aysegul; Kelestimur, Haluk; Kutlu, SelimApelin, which is a new hormone, is secreted especially in the brain by hypothalamus as well as by many other organs like the stomach, fat tissue, and the heart. For apelin, whose possible effects on many bodily functions like the endocrine system, cardiovascular system and metabolic activities are still under investigation, the reproductive system is also an important target area. The purpose of the present study was to investigate the effects of plasma apelin levels in rats that were in diestrus, pregnancy and lactation periods, and to examine its possible effects on myometrium contractions of pregnant rats and non-pregnant rats that were in diestrus period. The plasma apelin concentrations in female adult Wistar rats were determined with the ELISA method in the diestrus period, and on the 12th, 18th, and 21st days of the pregnancy, and on the 2nd and 10th days of lactation (n=7 for each group). In addition, the effect of apelin at 0.01, 0.1, 1 and 10 mu M doses on isometric contractions in the rat uterus on the 21st day of pregnancy and in diestrus period was tested by using isolated organ bath. This protocol was repeated under conditions that were pre-treated with protein kinase C inhibitor in calcium-free medium, and the possible effect of apelin on contractions and the mechanisms that might mediate this effect were investigated. When plasma apelin levels were compared with the rats in diestrus period, the apelin concentrations in the 21-day pregnancy group were high at a significant level (p<0.05); and low at a significant level in the 2-day lactation group (p<0.05). In myometrium contraction trials, it was observed that apelin induced the contractions. Apelin increased the frequency of the myometrium contractions at a significant level when applied at 1 mu M and 10 mu M concentrations (p<0.05 and p<0.001). Only after the apelin application at 10 mu M concentration did the amplitude of the contractions increase at a significant level (p<0.01). In the myometrium of the rats that were on the 21st day of pregnancy, the frequency of the contractions was statistically significant at 0.1 mu M, 1 mu M and 10 mu M doses (p<0.01). In addition, the amplitude of the contractions increased at a statistically significant level at 1 mu M and 10 mu M dose application (p<0.05 and p<0.01, respectively). The apelin application induced the contractions in calcium-free medium. When apelin was applied after the pre-application with protein kinase C inhibitor, no contractions were observed. The present study showed that apelin levels were increased at the end of pregnancy in rats, and the hormone induced the uterus contractions. This effect does not occur with protein kinase C inhibitor and in calcium-free medium, which shows that protein kinase C pathway might play a role in these mechanism. These findings show that apelin might be an endogenous peptide that plays a role on uterine contractions at birth in rats.Öğe Effects of Fluoxetine in Healty and Damaged Rat Aorta(Wiley, 2018) Taki, Fatma Nur; Solak, Hatice; Koca, Raviye Ozen; Ozdengul, Faik; Gormus, Z. Isik Solak; Kutlu, Selim[Abstract Not Availabe]
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