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    Cavitary pulmonary lesion due to systemic lupus erythematosus: An unusual manifestation
    (Professional Medical Publications, 2011) Maden, Emin; Teke, Turgut; Uzun, Kursat
    Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown pathogenesis. In this abstract we report a 34 years old female SLE case with cavitary pulmonary lesion as the pulmonary manifestation. In literature, SLE with cavitary pulmonary lesion is reported very rarely and thought to be due to infection or pulmonary embolism. Our case had no signs of infection and no finding of pulmonary embolism, the lesion resolved by steroid therapy and without antibiotic administration. In conclusion SLE should be thought in differential diagnosis of cavitary pulmonary lesions.
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    Cigarette smoke and bleomycin-induced pulmonary oxidative stress in rats
    (Spandidos Publ Ltd, 2012) Teke, Turgut; Maden, Emin; Kiyici, Aysel; Korkmaz, Celalettin; Gok, Mehmet; Ozer, Faruk; Imecik, Oktay
    Bleomycin causes pulmonary fibrosis by increasing free oxygen radicals. Cigarette smoke is a strong oxidant which adversely affects pulmonary tissue. We evaluated the effects of cigarette smoke administered with intratracheal bleomycin on pulmonary tissue. We studied 3 groups of rats (n=10): one group received intratracheal saline and served as a control; one received intratracheal Neomycin (IT) (0.5 U/100 g body weight, single dose on the first day), and one group received intratracheal bleomycin (single dose on first day) and tobacco smoke (two times per day) (IT-S). After 4 weeks, the levels of malondialdehyde (MDA) and nitric oxide (NO) and the activities of superoxide dismutase (SOD) and xanthine oxidase (XO) were assayed in the homogenate of the lung tissue samples. The severity of interstitial fibrosis was assessed using the grading system described by Ashcroft. There was more intensive fibrosis in the IT and IT-S than in the control samples (P<0.001). The levels of MDA., NO and activity of XO were significantly increased (P<0.001, <0.002 and <0.002, respectively), and SOD activity (P<0.001) was significantly decreased in the IT group when compared to these values in the control group. The concentration of NO was significantly decreased (P<0.002), and SOD activity was significantly increased (P<0.05) in the lung tissue samples of the IT-S group. Theoretically, the combination of cigarette smoke and bleomycin may have a synergistic effect on oxidative lung injury. In conclusion, we showed that inhalation of cigarette smoke provides protection against oxidative stress in the lung tissue of rats with bleomycin-induced pulmonary fibrosis.
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    Common Variable Immunodeficiency and Pulmonary Amyloidosis: A Case Report
    (Springer/Plenum Publishers, 2015) Arslan, Sevket; Ucar, Ramazan; Yavsan, Dudu Mehmet; Esen, Hasan; Maden, Emin; Reisli, Ismail; Caliskaner, Ahmet Zafer
    Common variable immunodeficiency is the most common symptomatic primary immune deficiency characterized by hypogammaglobulinemia, recurrent infections, and increased risk of autoimmune disease and malignancy. Secondary amyloidosis develops from chronic inflammatory conditions. The co-existence of CVID (especially in patients with bronchiectasis) and secondary amyloidosis has been reported rarely. We describe the first case of pulmonary hypertension secondary to pulmonary amyloidosis in a patient with CVID.
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    Effciency of Silver Coated Urinary Catheter in Catheter-Associated Urinary Tract Infection in Critical Care Unit
    (Aves, 2010) Teke, Turgut; Yavuz, Zuhal; Atalay, Huseyin; Maden, Emin; Solak, Yalcin; Uzun, Kursat
    with an incidence of 40%. The incidence of urosepsis occurs in approximately 16% of the ICU patient populations. The purpose of this study was to determine the efficacy of a silver coated urinary catheter in prevention of catheter-associated UTI. Material and Methods: We investigated 21 patients (mean age with 71.4 +/- 9.0 year and 14 M, 7 F) foley silicon urinary catheter and 20 patients (mean age with 67.6 +/- 8.7 year and 15 M, 5 F) with silver coated urinary catheter. In all patients, foley urinary catheters were changed with silver coated catheter in critical care unit. Results: The most common cause of infection was Klebsiella (33%). The susceptibility of gram negative microorganisms against antimicrobial agents were amicacin, piperacillin-tazobactam and carbapenem. The cost of antibiotic was higher in foley catheter group than silver coated group (p<0.001). Conclusion: Silver coated urinary catheter is expensive, it is cost effect according to urinary infection and antibiotic cost.