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Öğe Benign Tracheo-Gastric Fistula: A Case Which Occured 23 Years After Total Laryngopharyngoesophagectomy(2014) Metin, Bayram; Arıbaş, Olgun Kadir; İzzet Özgür, Özlük; Apilioğullari, Burhan; Özkan, EmreTotal özefajektomi ve lerenjektomiden sonra gelişen benign trakeo-yeni-özefagial (Gastrik) fistül nadir fakat yaşamı tehdit eden bir komplikasyondur. Larenjektomili hastalarda trakeo-özefageal fistül ve ses valf protezleri ses oluşturmada larenkse alternatif olarak kullanılırlar. Bizim vakamızda fistül alanında protezin etrafında mide asidine bağlı oluşan erozyon nedeni ile fistül semptomları gelişmiştir.Öğe Chronic Inflammation-Related Diffuse Large B-Cell Lymphoma Around the Area of Thoracotomy After Decortication(Derman Medical Publ, 2014) Metin, Bayram; Sahin, Sevinc; Ede, Huseyin; Kaya, Bugra; Erkoc, Mustafa FatihChest wall tumors consist 5% of all tumors in the thorax. Lymphomas compose of less than 5% of all primary chest wall malignancy. Sixty three years old patient who had an operation for pleural thickness two years ago admitted with complaint of left-sided chest pain. Following the detection of mass lesion radiologically at the place of previous operation area, the patient was operated based on needle biopsy result suggesting Ewing /PNET or pulmonary originated tumor. After the operation, pathological examination confirmed chronic inflammation-related diffuse large B-cell lymphoma. Since it has been rarely reported in the literature, we aimed to present the case of chronic inflammation-related diffuse large B-cell lymphoma developed within such a short time as two years on the ground of surgical incision scar tissue together with our radiologic, surgical, and pathological findings.Öğe Comparison of the effects of alpha lipoic acid and dexpanthenol in an experimental tracheal reconstruction animal model(Saudi Med J, 2023) Kuru, Murat; Altinok, Tamer; Metin, Bayram; Esen, Haci HasanObjectives: To investigate the positive effects of intraperitoneal administration of alpha-lipolic acid (ALA) and dexpanthenol (DXP) on wound healing after tracheal surgery in rats. Methods: The study was carried out at Necmettin Erbakan University, Konya, Turkey, from January 2014-2019. A total of 30 healthy and adult Sprague-Dawley type female rats were included in the study. For the experiment, rats were randomly divided into 3 groups: ALA group (n=10), DXP group (n=10), and control group (n=10). After trachea surgery, 100 mg/kg/day ALA was given to group ALA and 100 mg/kg/day intraperitoneal DXP to group DXP for 15 days, and the rats were sacrificed on the 21st day. The excised tracheal sections were evaluated and graded for inflammatory cell infiltration, angiogenesis, fibroblast proliferation, collagen deposition, and epithelial regeneration to evaluate wound healing. Results: Inflammation was found to be less in both the ALA and DXP groups. With the Mann-Whitney test, it was determined that inflammation was less in the ALA group than in the DXP group (C-D [p=0.097] and C-A [p=0.024]). On the other hand, no statistically significant difference was found in epithelial regeneration (p=0.574; >0.05), angiogenesis (p=0.174; >0.05), fibroblast proliferation, and collagen deposition (p=0.102; >0.05). Conclusion: Alpha-lipolic acid injected intravenously after tracheal reconstruction in patients can prevent restenosis by reducing inflammation without adversely affecting wound healingÖğe Comparison of the effects of alpha lipoic acid and dexpanthenol in an experimental tracheal reconstruction animal model(Saudi Med J, 2023) Kuru, Murat; Altinok, Tamer; Metin, Bayram; Esen, Haci HasanObjectives: To investigate the positive effects of intraperitoneal administration of alpha-lipolic acid (ALA) and dexpanthenol (DXP) on wound healing after tracheal surgery in rats. Methods: The study was carried out at Necmettin Erbakan University, Konya, Turkey, from January 2014-2019. A total of 30 healthy and adult Sprague-Dawley type female rats were included in the study. For the experiment, rats were randomly divided into 3 groups: ALA group (n=10), DXP group (n=10), and control group (n=10). After trachea surgery, 100 mg/kg/day ALA was given to group ALA and 100 mg/kg/day intraperitoneal DXP to group DXP for 15 days, and the rats were sacrificed on the 21st day. The excised tracheal sections were evaluated and graded for inflammatory cell infiltration, angiogenesis, fibroblast proliferation, collagen deposition, and epithelial regeneration to evaluate wound healing. Results: Inflammation was found to be less in both the ALA and DXP groups. With the Mann-Whitney test, it was determined that inflammation was less in the ALA group than in the DXP group (C-D [p=0.097] and C-A [p=0.024]). On the other hand, no statistically significant difference was found in epithelial regeneration (p=0.574; >0.05), angiogenesis (p=0.174; >0.05), fibroblast proliferation, and collagen deposition (p=0.102; >0.05). Conclusion: Alpha-lipolic acid injected intravenously after tracheal reconstruction in patients can prevent restenosis by reducing inflammation without adversely affecting wound healingÖğe Congenital Emphysema As a Rare Etiology of Scoliosis(2015) Metin, Bayram; Arıbaş, Olgun Kadir; Özkan, Emre; Apilioğullari, BurhanDoğumsal amfizem, yenidoğanlarda ilgili akciğer alanının hiperinflasyonu, amfizematöz akciğer alanının çevredeki normal akciğer dokusuna basısı ve mediastinal kayma ile karakterizedir. Skolyoz ise vertebraların yana doğru eğrildiği bir durumdur. Skolyoza neden olan birçok etken olmasına rağmen, bildiğimiz kadarıyla literatürde amfizeme sekonder gelişen skolyoz bildirilmemiştir. Bu yazıda, doğumsal pulmoner amfizeme bağlı geliştiğini düşündüğümüz bir skolyoz olgusu sunuldu.Öğe Deneysel pulmoner parankim yaralanması yapılan tavşanlarda ankaferd® uygulamasının parankimal kanama kontrolü, yara iyileşmesi, hava kaçağı ve plevral yapışıklık üzerinde etkileri (Deneysel Çalışma)(Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, 2010) Metin, Bayram; Altınok, TamerDeneysel pulmoner parankim yaralanması yapılan tavşanlarda Ankaferd® uygulamasının parankimal kanama kontrolü, yara iyileşmesi, hava kaçağı ve plevral yapışıklık üzerinde etkileri (Deneysel Çalışma)Amaç: Biz çalışmamızda deneysel pulmoner parankim hasarı yapılan tavşanlarda kanama kontrolü, yara iyileşmesi, hava kaçağı ve plevral yapışıklık üzerinde geleneksel Türk hekimliğinde hemostatik ajan olarak kullanılmış bir bitkisel ekstrakt olan Ankaferd® uygulamasının etkinliğini değerlendirmeyi amaçladık.Gereç ve yöntem: Bu çalışmada 16 adet Yeni Zellanda türü albino erkek veya dişi tavşan kullanıldı. Tavşanlar iki gruba ayrıldı. İki grupta da birer tavşan anestezi sırasında eksitus oldu. Her iki grupta da 7 adet tavşan mevcuttu. Her iki gruptaki tüm tavşanların sol alt loblarına eşit büyüklükte wedge rezeksiyon yapıldı. Daha sonra çalışma grubundaki tüm tavşanların rezeksiyon alanına 5 puf(1cc) ABS sprey uygulanırken, kontrol grubundakilere herhangi bir ek müdahele yapılmadı. İki grupta da göğüs tüpü konularak torakotomileri kapatıldı. Postoperatif 6 saat boyunca drenaj ve hava kaçağı takipleri yapıldıktan sonra drenleri aspire edilerek çekildi ve 8 günlük takibe alındı. Sekiz gün sonra tavşanlar yüksek doz anestezi ile sakrifiye edilerek sol hemitorakstaki yapışıklıklar makroskobik ve mikroskobik olarak incelendi. Biyokimyasal olarak doku MDA ve HPR düzeyleri ölçüldü.Bulgular: İstatistiksel olarak kontrol grubunda Postoperatif hava kaçağı ve drenaj miktarı daha fazla idi (Kanama miktarı P<0.05, hava kaçağı P<0.001). Makroskopik ve mikroskopik fibrozis açısından çalışma grubunda daha fazla fibrozis ile karşılaşıldı (P<0.0001). Doku MDA düzeyi açısından iki grup arasında fark bulunmadı ve bu durum serbest oksijen radikallerinin dokulardaki olası zararlı etkilerinin, Ankaferd®'ce artırılmadığının göstergesi olarak değerlendirildi. HPR düzeyleri iki grup arasında farklı bulunmadığı için akciğer dokusunda ABS'in yara iyilşemesi üzerinde net bir etkinliği gösterilemedi. Bunun nedeni olarakta analizler için tercih edilen postoperatif gün ve vaka sayılarının farklılıklarından kaynaklı olabileceğini düşünmekteyiz.Sonuç: ABS toksik etkiye yol açmadan postoperatif kanamaları ve uzamış hava kaçaklarını azaltmakta ve plevral fibrozis düzeyini arttırarak etkin bir plörodezis yapmaktadır.Anahtar Kelimeler: Ankaferd®, Toraks Cerrahisi, Reoperasyon.Öğe The effects of ankaferd blood stopper on DNA damage and enzymes with paranchymal damaged rabbits(2017) Metin, Bayram; Menevşe, Esma; Sivrikaya, Abdullah; Altınok, Tamer; Arıkoğlu, HilalAnkaferd blood stopper (ABS) is a medical product that is used in several injuries, dental operations, prevention of minor or major bleeding after spontaneous or surgerical operations and have anti-microbial, anti-inflamatory, anti-thrombin, anti-platelet, anti-atherosclerotic, anti-oxidants effects. The present study is aimed to evaluate the effects of ABS on 8-hydroxy-2?-deoxyguanosine (8-OHdG), superoxide dismutase (SOD), myeloperoxidase (MPO) levels over pleural adhesions in rabbits with pulmonary parenchymal damage.16 New Zelland species rabbits were divided in two groups such as control (n7) and study group (n7). One rabbit in each group died during anesthesia. In both groups, we performed wedge resections in equal size to the left lower lobes of all rabbits. No interventions were made on control group, whereas 5 puff’s (1 cc) ABS was performed to the resection area at study group. Tube thoracostomy that performed both groups were terminated postoperatively at 6th hour after drainage and air leakages follow up. Rabbits were sacrificed with anesthetics at postoperative 8th day. Lung tissues were collected for analyzing of 8-OHdG, SOD, MPO. The 8-OHdG levels were respectively 2.010.39 ng/ml in control group and, 0.380.12 ng/ml in study. The differences between study and control group were statistically important group (p0.001). SOD and MPO levels did not show any statistically importance in the groups. As a conclusion, we can say that oxidative DNA damage prevented by ABS.Öğe Evaluation of the effects of ankaferd blood stopper on rabbits with paranchyme damage: an experimental study(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2013) Metin, Bayram; Altinok, Tamer; Menevse, Esma; Esen, HasanBackground: In this study, we aimed to evaluate the effects of Ankaferd Blood Stopper (ABS), a herbal extract used as a hemostatic agent in traditional Turkish medicine, on hemostasis, wound healing, air leakage and the efficiency over pleural adhesions in rabbits with pulmonary parenchymal damage. Methods: Sixteen New Zelland Albino type male and female rabbits with a mean weight of 2500 g were used. The rabbits were divided into two groups as study group and control group. One rabbit in each group died during anesthesia. We performed wedge resections in equal size to the left lower lobes of all rabbits. No additional procedure was performed on the control group, while the study group received 5 puffs (similar to 1 cc) of ABS to the resection area. Tube thoracostomy, which was performed in both groups, was terminated postoperatively at the sixth hours after drainage and air leakage follow-up. The rabbits were sacrificed with high dose anesthetic at the postoperative eight-day. Pleural inflammation and fibrosis in the hemithorax were examined macroscopically and microscopically. Biochemical measurements of tissue malondialdehyde (MDA) and hydroxyprolin (HPR) levels were done. Results: There was a statistically significant difference in postoperative air leakage and the amount of drainage between the groups (amount of hemorrhage p<0.05, air leakage p<0.001). A higher rate of macroscopic and microscopic fibrosis was observed in the study group. When both groups are compared according to tissue MDA levels, decreased MDA level was seen in the group which ABS was administered, where the difference was statistically non-significant. Conclusion: Ankaferd Blood Stopper reduces postoperative bleeding and prolonged air leakages without any toxic effects and has an effective role at pleurodesis, increasing the pleural fibrosis level.Öğe Nörojenik tümörü taklit eden nadir bir özofagus duplikasyon kisti: Olgu sunumu(2012) Döngel, İsa; Bayram, Mehmet; Metin, Bayram; Ceran, Sami; Sunam, Güven SadiGastrointestinal sistem (GİS) kaynaklı duplikasyon kisti, nadir görülen konjenital lezyonlardır. Gastrointestinal sistemin anormal kanalizasyonu sonucu oluşurlar. GİS boyunca herhangi bir yerde görülebilirler, fakat en sık sağ posterior mediastene yerleşirler. Tesadüfen çekilen PA akciğer grafisinde patoloji saptanan bayan hasta kliniğimize 20 yaşındaki yönlendirildi. Sağda ekstrapulmoner yerleşimli paravertebral bölgede, azygoözefageal resese uzanan kistik yapıdaki lezyon sağ torakotomi ile çıkarıldı. Histopatolojik tanısı özofagus duplikasyon kisti olarak raporlandı. Eşlik eden başka bir patoloji mevcut değildi. Bu çalışmada paravertebral yerleşimli kistik lezyonların ayırıcı tanısının yapılabilmesi ve literatür bilgileri eşliğinde duplikasyon kistinin değerlendirilmesi amaçlandı.Öğe Our transthoracic biopsy practices accompanied by the imaging process: The contribution of positron emission tomography usage to accurate diagnosis(Taylor & Francis Ltd, 2016) Intepe, Yavuz Selim; Metin, Bayram; Sahin, Sevinc; Kaya, Bugra; Okur, AylinObjectives: The objective of this study was to compare the results of transthoracic biopsies performed through the use of FDG PET/CT imaging with the results of transthoracic needle biopsy performed without using the FDG PET/CT imaging.Methods: The medical files of a total of 58 patients with pulmonary and mediastinal masses. A total of 20 patients, who were suspected of malignancy with the SUVmax value of over 2.5 in FDG PET/CT, underwent a biopsy process. Twelve patients with no suspicion of malignancy in accordance with CT images and with the SUVmax value below 2.5 underwent no biopsy procedure, and hence, they were excluded from the study. On the other hand, 26 patients directly went through a biopsy process with the suspicion of malignancy according to CT imaging, regardless of performing any FDG PET/CT imaging.Results: According to the biopsy results, the number of the patients diagnosed with cancer was 20 (43.5%), while the number of non-cancerous patients was 26 (56.5%). When these findings were considered, it was determined that the sensitivity of the whole TTNB (transthoracic needle biopsy) was 80.8%, and the specificity was found as 100%. The positive predictive value of the whole TTNB was 100%, while its negative predictive value was found to be 80%. The sensitivity in TTNB performed together with FDG PET/CT was 90.9%, whereas the specificity was 100%. The positive predictive value of TTNB with FDG PET/CT was 100%, while its negative predictive value was found to be 81.8%. The sensitivity in TTNB performed without the use of FDG PET/CT was 73.3%, whereas the specificity was determined as 100%.Conclusions: Performing FDG PET/CT imaging process prior to a transthoracic biopsy as well as preferring FDG PET/CT for the spot on which the biopsy will be performed during the transthoracic biopsy procedure increases the rate of receiving accurate diagnosis.Öğe Parabronchial Diverticulum of Esophagus: Report of a Case(2015) Altuntaş, Bayram; Uyanıkoğlu, Ahmet; Ceran, Sami; Sunam, Güven Sadi; Metin, BayramParabronşiyal ya da midözefagiyal divertiküller, özefagusun orta kesiminin periözefagiyal alana doğru kese şeklinde büyümesi sonucu ortaya çıkar. Bu büyüme genellikle mediastinel inflamasyona sekonder olarak oluşur. Biz, midözefagiyal divertikülü olan yirmibir yaşında erkek hastayı sunuyoruz. Literatür bilgileri eşliğinde bu özefagiyal patolojiyi tartışmayı amaçladık.
