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    Use of guanine-modified glassy carbon electrode as an electrochemical sensor for the determination of paracetamol
    (Bangladesh Pharmacological Soc, 2023) Islamoglu, Nesim; Mulazimoglu, Ayen Demir
    In this study, guanine-modified glassy carbon electrode sensor was developed for the determination of paracetamol. The use of overdose continuously for a long time, its metabolites accumulate and affect the kidneys and liver. There-fore, the detection of paracetamol is of great significance. Differential pulse voltammetry and cyclic voltammetry techniques were employed to analyze the behavior of paracetamol in 0.1 M Britton-Robinson buffer solution of pH 5.0 on guanine-modified electrode. Guanine-modified glassy carbon electrode showed a good linear response in the concentration range from 0.5 mM to 10 & mu;M for the quantitative determination of paracetamol with the lower limit of detection of 0.9 & mu;M.